1,351 research outputs found
Isotope effect on superconductivity in Josephson coupled stripes in underdoped cuprates
Inelastic neutron scattering data for YBaCuO as well as for LaSrCuO indicate
incommensurate neutron scattering peaks with incommensuration away
from the point. can be replotted as a linear function of
the incommensuration for these materials. This linear relation implies that the
constant that relates these two quantities, one being the incommensuration
(momentum) and another being (energy), has the dimension of velocity
we denote : . We argue that this
experimentally derived relation can be obtained in a simple model of Josephson
coupled stripes. Within this framework we address the role of the isotope effect on the . We assume that the incommensuration is
set by the {\em doping} of the sample and is not sensitive to the oxygen
isotope given the fixed doping. We find therefore that the only parameter that
can change with O isotope substitution in the relation
is the velocity . We predict an oxygen isotope effect on and expect
it to be .Comment: 4 pages latex file, 2 eps fig
Spinful bosons in an optical lattice
We analyze the behavior of cold spin-1 particles with antiferromagnetic
interactions in a one-dimensional optical lattice using density matrix
renormalization group calculations. Correlation functions and the dimerization
are shown and we also present results for the energy gap between ground state
and the spin excited states. We confirm the anticipated phase diagram, with
Mott-insulating regions of alternating dimerized S=1 chains for odd particle
density versus on-site singlets for even density. We find no evidence for any
additional ordered phases in the physically accessible region, however for
sufficiently large spin interaction, on-site singlet pairs dominate leading,
for odd density, to a breakdown of the Mott insulator or, for even density, a
real-space singlet superfluid.Comment: Minor revisions and clarification
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The JAK inhibitor tofacitinib suppresses synovial JAK1-STAT signalling in rheumatoid arthritis.
ObjectiveTofacitinib is an oral Janus kinase (JAK) inhibitor for the treatment of rheumatoid arthritis (RA). The pathways affected by tofacitinib and the effects on gene expression in situ are unknown. Therefore, tofacitinib effects on synovial pathobiology were investigated.MethodsA randomised, double-blind, phase II serial synovial biopsy study (A3921073; NCT00976599) in patients with RA with an inadequate methotrexate response. Patients on background methotrexate received tofacitinib 10 mg twice daily or placebo for 28 days. Synovial biopsies were performed on Days -7 and 28 and analysed by immunoassay or quantitative PCR. Clinical response was determined by disease activity score and European League Against Rheumatism (EULAR) response on Day 28 in A3921073, and at Month 3 in a long-term extension study (A3921024; NCT00413699).ResultsTofacitinib exposure led to EULAR moderate to good responses (11/14 patients), while placebo was ineffective (1/14 patients) on Day 28. Tofacitinib treatment significantly reduced synovial mRNA expression of matrix metalloproteinase (MMP)-1 and MMP-3 (p<0.05) and chemokines CCL2, CXCL10 and CXCL13 (p<0.05). No overall changes were observed in synovial inflammation score or the presence of T cells, B cells or macrophages. Changes in synovial phosphorylation of signal transducer and activator of transcription 1 (STAT1) and STAT3 strongly correlated with 4-month clinical responses (p<0.002). Tofacitinib significantly decreased plasma CXCL10 (p<0.005) at Day 28 compared with placebo.ConclusionsTofacitinib reduces metalloproteinase and interferon-regulated gene expression in rheumatoid synovium, and clinical improvement correlates with reductions in STAT1 and STAT3 phosphorylation. JAK1-mediated interferon and interleukin-6 signalling likely play a key role in the synovial response.Trial registration numberNCT00976599
Quantum Ising model in a transverse random field: A density-matrix renormalization group analysis
The spin-1/2 quantum Ising chain in a transverse random magnetic field is
studied by means of the density-matrix renormalization group. The system
evolves from an ordered to a paramagnetic state as the amplitude of the random
field is increased. The dependence of the magnetization on a uniform magnetic
field in the z direction and the spontaneous magnetization as a function of the
amplitude of the transverse random magnetic field are determined. The behavior
of the spin-spin correlation function both above and at criticality is studied.
The scaling laws for magnetization and correlation functions are tested against
previous numerical and renormalization-group results.Comment: 5 pages with 7 figures inside them, proper format of authors' names
use
Topoisomer Differentiation of Molecular Knots by FTICR MS: Lessons from Class II Lasso Peptides
Lasso peptides constitute a class of bioactive peptides sharing a knotted
structure where the C-terminal tail of the peptide is threaded through and
trapped within an N-terminalmacrolactamring. The structural characterization of
lasso structures and differentiation from their unthreaded topoisomers is not
trivial and generally requires the use of complementary biochemical and
spectroscopic methods. Here we investigated two antimicrobial peptides
belonging to the class II lasso peptide family and their corresponding
unthreaded topoisomers: microcin J25 (MccJ25), which is known to yield
two-peptide product ions specific of the lasso structure under collisioninduced
dissociation (CID), and capistruin, for which CID does not permit to
unambiguously assign the lasso structure. The two pairs of topoisomers were
analyzed by electrospray ionization Fourier transform ion cyclotron resonance
mass spectrometry (ESI-FTICR MS) upon CID, infrared multiple photon
dissociation (IRMPD), and electron capture dissociation (ECD). CID and
ECDspectra clearly permitted to differentiate MccJ25 from its non-lasso
topoisomer MccJ25-Icm, while for capistruin, only ECD was informative and
showed different extent of hydrogen migration (formation of c\bullet/z from
c/z\bullet) for the threaded and unthreaded topoisomers. The ECD spectra of the
triply-charged MccJ25 and MccJ25-lcm showed a series of radical b-type product
ions {\eth}b0In{\TH}. We proposed that these ions are specific of
cyclic-branched peptides and result from a dual c/z\bullet and y/b
dissociation, in the ring and in the tail, respectively. This work shows the
potentiality of ECD for structural characterization of peptide topoisomers, as
well as the effect of conformation on hydrogen migration subsequent to electron
capture
Ground-state properties of a supersymmetric fermion chain
We analyze the ground state of a strongly interacting fermion chain with a
supersymmetry. We conjecture a number of exact results, such as a hidden
duality between weak and strong couplings. By exploiting a scale free property
of the perturbative expansions, we find exact expressions for the order
parameters, yielding the critical exponents. We show that the ground state of
this fermion chain and another model in the same universality class, the XYZ
chain along a line of couplings, are both written in terms of the same
polynomials. We demonstrate this explicitly for up to N = 24 sites, and provide
consistency checks for large N. These polynomials satisfy a recursion relation
related to the Painlev\'e VI differential equation, and using a scale-free
property of these polynomials, we derive a simple and exact formula for their
limit as N goes to infinity.Comment: v2: added more information on scaling function, fixed typo
Prediction of Outcome After Endovascular Embolectomy in Anterior Circulation Stroke Using Biomarkers
Stroke is a major public health problem that can cause a long-term disability or death due to brain damage. Serious stroke is frequently caused by a large vessel occlusion in the anterior circulation, which should be treated by endovascular embolectomy if possible. In this study, we investigated the use of the brain damage biomarkers tau, NFL, NSE, GFAp, and S100B to understand the progression of nervous tissue damage and their relationship to outcome in such stroke after endovascular treatment. Blood samples were taken from 90 patients pre-treatment and 2 h, 24 h, 48 h, 72 h and 3 months after endovascular treatment. Stroke-related neurological deficit was estimated using the National Institute of Health Stroke Scale (NIHSS) at admission and at 24 h. Neurological outcome was evaluated at 3 months. After stroke, tau, NFL, GFAp and S100B increased in a time dependent manner, while NSE remained constant over time. At 3 months, tau and GFAp levels were back to normal whereas NFL was still high. Tau, NFL and GFAp correlated well to outcome, as well as to infarct volume and NIHSS at 24 h. The best time for prediction of poor outcome was different for each biomarker. However, the combination of NIHSS at 24 h with either tau, NFL or GFAp at 48 h gave the best prediction. The use of biomarkers in the early setting after endovascular treatment of stroke will lead to a simplified and standardized way to estimate the nervous tissue damage and possibly complement the clinical judgement in foreseeing the need of rehabilitation measures
Three-coloring statistical model with domain wall boundary conditions. I. Functional equations
In 1970 Baxter considered the statistical three-coloring lattice model for
the case of toroidal boundary conditions. He used the Bethe ansatz and found
the partition function of the model in the thermodynamic limit. We consider the
same model but use other boundary conditions for which one can prove that the
partition function satisfies some functional equations similar to the
functional equations satisfied by the partition function of the six-vertex
model for a special value of the crossing parameter.Comment: 16 pages, notations changed for consistency with the next part,
appendix adde
The effects of the spontaneous presence of a spouse/partner and others on cardiovascular reactions to an acute psychological challenge
The presence of supportive others has been associated with attenuated cardiovascular reactivity in the laboratory. The effects of the presence of a spouse and others in a more naturalistic setting have received little attention. Blood pressure and heart rate reactions to mental stress were recorded at home in 1028 married/partnered individuals. For 112 participants, their spouse/partner was present; for 78, at least one other person was present. Women tested with a spouse/partner present showed lower magnitude systolic blood pressure and heart rate reactivity than those tested without. Individuals tested with at least one nonspousal other present also displayed attenuated reactivity. This extends the results of laboratory studies and indicates that the spontaneous presence of others is associated with a reduction in cardiovascular reactivity in an everyday environment; spouse/partner presence would appear to be especially effective for women.\ud
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Direction-dependent excitatory and inhibitory ocular vestibular-evoked myogenic potentials (oVEMPs) produced by oppositely directed accelerations along the midsagittal axis of the head
Oppositely directed displacements of the head need oppositely directed vestibulo-ocular reflexes (VOR), i.e. compensatory responses. Ocular vestibular-evoked myogenic potentials (oVEMPs) mainly reflect the synchronous extraocular muscle activity involved in the process of generating the VOR. The oVEMPs recorded beneath the eyes when looking up represent electro-myographic responses mainly of the inferior oblique muscle. We aimed: (1) to study the properties of these responses as they were produced by head acceleration impulses to the forehead and to the back of the head; (2) to investigate the relationships between these responses and the 3-D linear head accelerations that might reflect the true stimulus that acts on the vestibular hair cells. We produced backward- and forward-directed acceleration stimuli in four conditions (positive and negative head acceleration impulses to the hairline and to the inion) in 16 normal subjects. The oVEMPs produced by backward- and forward-directed accelerations of the head showed consistent differences. They were opposite in the phase. The responses produced by backward accelerations of the head began with an initial negativity, n11; conversely, those produced by accelerations directed forward showed initially a positive response, p11. There was a high inter-subject correlation of head accelerations along the head anteroposterior and transverse axes, but almost no correlation of accelerations along the vertical axis of the head. We concluded that backward-directed head accelerations produced an initial excitatory response, and forward-directed accelerations of the head were accompanied by an initial inhibitory response. These responses showed dependence on acceleration direction in the horizontal plane of the head. This could be consistent with activation of the utricle
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