The Relation of Anxiety, Depression, and Stress to Binge Eating Behavior

Binge eating is an impairing and prevalent problem. Theories of binge eating suggest negative affect is of primary importance in the development and maintenance of binge eating behavior. To date, investigations of binge eating have often examined depression, however relatively little is known about other psychological factors. The current study aimed to extend the literature by examining several psychological factors in relation to binge eating behavior. Specifically, the relation between binge eating behavior and three psychological factors, depression, anxiety and stress, were examined. Data were collected via online surveys from a community sample of men and women of diverse backgrounds. The main study hypotheses were supported, indicating a unique relation between anxiety and binge eating, and between stress and binge eating, independent of the impact of depression. Additionally, secondary analyses supported the role of cognitive avoidance as a mediator in the relation of anxiety and binge eating. Hostility was also examined in relation to binge eating. The results of this study suggest a need for greater inclusivity (i.e., anxiety, stress) of dimensions of negative affect in examinations of binge eating. Further, focused attention regarding the role of anxiety may be important for future binge eating research

The Role of Anxiety in Binge Eating Behavior: A Critical Examination of Theory and Empirical Literature

The purpose of this manuscript is to expand the understanding of binge eating by reviewing the role of aspects of negative affect. Specifically, this paper will present evidence for further investigation of the bearing that anxiety may have in binge eating development and maintenance. A comprehensive review of the literature regarding the relation of binge eating and anxiety was performed. Valuable contributions have been made to the binge eating literature regarding some aspects of negative affect (i.e., depression); however, outside of bulimia nervosa studies, much of the theoretical and empirical binge eating research to date has not directly addressed the role of anxiety. Research supports expansion of investigations of negative emotionality and binge eating to include specific study of anxiety. Greater inclusivity and specificity in the unique contributions of various negative emotions may further the development of temporal models and intervention efforts

The role of anxiety in binge eating behavior: a critical examination of theory and empirical literature

The purpose of this manuscript is to expand the understanding of binge eating by reviewing the role of aspects of negative affect. Specifically, this paper will present evidence for further investigation of the bearing that anxiety may have in binge eating development and maintenance. A comprehensive review of the literature regarding the relation of binge eating and anxiety was performed. Valuable contributions have been made to the binge eating literature regarding some aspects of negative affect (i.e., depression); however, outside of bulimia nervosa studies, much of the theoretical and empirical binge eating research to date has not directly addressed the role of anxiety. Research supports expansion of investigations of negative emotionality and binge eating to include specific study of anxiety. Greater inclusivity and specificity in the unique contributions of various negative emotions may further the development of temporal models and intervention efforts

Multiple novel prostate cancer susceptibility signals identified by fine-mapping of known risk loci among Europeans

Genome-wide association studies (GWAS) have identified numerous common prostate cancer (PrCa) susceptibility loci. We have fine-mapped 64 GWAS regions known at the conclusion of the iCOGS study using large-scale genotyping and imputation in 25 723 PrCa cases and 26 274 controls of European ancestry. We detected evidence for multiple independent signals at 16 regions, 12 of which contained additional newly identified significant associations. A single signal comprising a spectrum of correlated variation was observed at 39 regions; 35 of which are now described by a novel more significantly associated lead SNP, while the originally reported variant remained as the lead SNP only in 4 regions. We also confirmed two association signals in Europeans that had been previously reported only in East-Asian GWAS. Based on statistical evidence and linkage disequilibrium (LD) structure, we have curated and narrowed down the list of the most likely candidate causal variants for each region. Functional annotation using data from ENCODE filtered for PrCa cell lines and eQTL analysis demonstrated significant enrichment for overlap with bio-features within this set. By incorporating the novel risk variants identified here alongside the refined data for existing association signals, we estimate that these loci now explain ∼38.9% of the familial relative risk of PrCa, an 8.9% improvement over the previously reported GWAS tag SNPs. This suggests that a significant fraction of the heritability of PrCa may have been hidden during the discovery phase of GWAS, in particular due to the presence of multiple independent signals within the same regio

Understanding eating disorder symptoms in same-gender couples: social environmental factors

Plain English summary Sexual minority individuals are at disproportionately greater risk for eating disorders, yet little is known about the ways in which factors in the social environment relate to eating disorder symptoms in this population. This research investigates sociocultural attitudes and romantic relationship quality as factors in the social environment in relation to eating disorder symptoms for men and women in same-gender relationships. We found differences in the occurrence of eating disorder symptoms, such that sexual minority men had more uncontrolled eating compared to sexual minority women. Across all participants, internalization of sociocultural attitudes was linked to greater disordered eating symptoms. We also investigated a potential buffering role of a romantic partner on eating disorder symptoms, and found that high quality, committed, romantic relationships were beneficially associated with less uncontrolled eating for sexual minority men