10 research outputs found
Antitumour activity of some plants from Meghalaya and Mizoram against murine ascites Dalton's lymphoma
981-988Total five plants, three from Mizoram (Dillenia
pentagyna, Ageratum conyzoides, Blumea lanceolaria) and two from Meghalaya
(Potentilla fulgens, Taxus baccata) were studied for their antitumour
activity against murine ascites Dalton's lymphoma (DL) in vivo.Only
three plants showed the different magnitude of anti tumour activity. Out of
these three plants,
the antitumour activity was maximally
observed with the methanol extract of the stem bark of D. pentagyna as
compared to the aqueous extract of the roots of A.conyzoides and aqueous
extract of the root of P. fulgens. An increase in glutathione levels in Dalton's lymphoma cells
was observed during tumour growth. Changes in glutathione and protein levels
were also
investigated in the liver and Dalton's lymphoma cells of
tumour-bearing mice following the treatment with the extract of D. pentagyna
which showed the highest anti tumour activity as compared to the other two
plant extracts. Glutathione in the liver and DL cells of treated tumour-bearing
mice was found to be decreased. The protein concentration in liver and DL
cells decreased mainly at 96 hr of
treatment. It may be concluded that the natural product of D. pentagyna
promises to be more active against Dalton's
lymphoma than others and the decrease in glutathione level may be one of the
important steps in resulting this antitumour effect