Results of multivariate analysis including all potential covariates predicting severe bronchiolitis in 378 infants admitted to hospital.

<p>The reference category is: No supplemental oxygen needed. Goodness of fit, Pearson's Χ² = 609 (p = 0.040) and Deviance is not significant (p = 0.999).</p

Demographic characteristics of 378 infants admitted with bronchiolitis and univariate analysis.

<p>Nominal data expressed as number and per cent of complete data for that factor, missing data excluded. Scale data expressed as group mean and (95% Confidence Interval).† Chi-square (Χ²) comparison with England 2001 census birth to one year old sex data.</p

Results of multivariate analysis; independent variables predicting severe bronchiolitis in 299 RSV positive infants admitted to hospital with bronchiolitis.

<p>The reference category is: No supplemental oxygen needed. Variables included but rejected where the Odds Ratios were not significant in both dependent outcomes included sex, gestation, birth-weight, corrected age on admission, family history of atopy, and deprivation score (IMD 2004). Goodness of fit, Pearson's Χ² = 663 (p<0.001) and Deviance is not significant (p = 0.999).</p

Results of multivariate analysis; independent variables predicting severe bronchiolitis in 378 infants admitted to hospital.

<p>The reference category is: No supplemental oxygen needed. Variables included but rejected where the Odds Ratios were not significant in both dependent outcomes included sex, gestation, birth-weight, corrected age on admission, family history of atopy, and deprivation score (IMD 2004). Goodness of fit, Pearson's Χ² = 726 (p<0.001) and Deviance is not significant (p = 0.999).</p

Proportion of infants by deprivation quintile.

<p>Deprivation quintiles (1 least deprived, 5 most deprived); infants recruited to this study with bronchiolitis (black), all Liverpool infants in 2001 census (grey) and all English infants in 2001 census (white).</p

Parents’ agenda items identified in trial recruitment discussions and interview analysis.

<p>(N = 41 families).</p

Invitations to elicit parents’ questions in parent-practitioner discussions about clinical trials.

<p>Invitations to elicit parents’ questions in parent-practitioner discussions about clinical trials.</p

Parent misunderstandings linked to important issues as identified in the interviews.

<p>(N = 41 families).</p

Demographic and trial participation trajectory of parents.

<p>(N = 41 families).</p

Children's demographic characteristics, medicine type and ADR information.

1<p>Age reported in year groups: 0–2; 3–5; 6–11; 12 years and over.</p>2<p>Calculated using Lower Super Output Area (LSOA) 2007 ranked score data, whereby lower scores indicate greater deprivation (data for families outside England are not reported due to incompatibility between IMD scoring systems within UK).</p>3<p>Severity scores were assessed using the Hartwig scale <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0046022#pone.0046022-Hartwig1" target="_blank">[84]</a> where 1 = No change in treatment with suspected drug; 2 = Drug dosing or frequency changed, without antidote or treatment for exhibited symptoms; 3 = Required treatment, or drug administration discontinued; 4 = Resulted in patient transfer to higher level of care; 5 = Caused permanent harm to patient or significant haemodynamic instability; 6 = Directly or indirectly resulted in patient death.</p