Ect2/Pbl Acts via Rho and Polarity Proteins to Direct the Assembly of an Isotropic Actomyosin Cortex upon Mitotic Entry.

Entry into mitosis is accompanied by profound changes in cortical actomyosin organization. Here, we delineate a pathway downstream of the RhoGEF Pbl/Ect2 that directs this process in a model epithelium. Our data suggest that the release of Pbl/Ect2 from the nucleus at mitotic entry drives Rho-dependent activation of Myosin-II and, in parallel, induces a switch from Arp2/3 to Diaphanous-mediated cortical actin nucleation that depends on Cdc42, aPKC, and Par6. At the same time, the mitotic relocalization of these apical protein complexes to more lateral cell surfaces enables Cdc42/aPKC/Par6 to take on a mitosis-specific function-aiding the assembly of a relatively isotropic metaphase cortex. Together, these data reveal how the repolarization and remodeling of the actomyosin cortex are coordinated upon entry into mitosis to provide cells with the isotropic and rigid form they need to undergo faithful chromosome segregation and division in a crowded tissue environment

The Transition to College Process in PR-CETP Scholars

This article describes a study about the experiences of a group of students during the transition from high school to college. The students are future teachers who evidenced a high level of academic achievement in high school and received merit scholarships from the Puerto Rico Collaborative for Excellence in Teacher Preparation (PR-CETP). Two groups of students were compared: those who sustained a high GPA during their freshman year, and those who did not and, therefore, no longer qualified for the scholarship. The study was carried out through focused interviews with eight students, from three universities, four of whom maintained the scholarship and four who did not. Findings indicate that the main problems encountered were academic and social, and that the students received support from their families during the entire process. Regarding formal support, they pointed out that they felt highly satisfied with the services provided by PR-CETP and the universities, but they also pointed out (particularly those who lost the scholarship) that they needed additional services from the universities. They suggested, for example, better tutoring, and social activities among the scholars. The interviewed students, in general, consider that they faced the transition successfully since most of them described their academic, emotional, and social status as satisfactory at the time of the interviews

La rappresentazione del rapporto tra utenti e sistema sanitario: I modelli culturali dei medici di medicina generale - The representation of the relationship between users and healthcare system: Cultural models of general practitioners

The present research study explores the emotional and symbolic representation of the Italian healthcare system and specifically of general medical services reported by a group of Italian general practitioners. General medicine is recently affected by a structural change which could be sustained also by a cultural revolution, however this revolution seems to be oriented to expected values without a clear methodology which promotes and accompanies this cultural change. The present study deals with the lack of practices due to these unrealized expected values and assumes that for intervening it is necessary knowing the existing culture before thinking to change it. Interviews to 36 general practitioners were analyzed by Emotional Text Analysis (AET). Results highlight a factorial space characterized by five clusters. According to respondents’ perspective, healthcare problems refer to two large issues characterized by powerlessness of general practitioners to intervene. On the one hand, there is health emergency, dealt with by first aid and emergency medicine. On the other hand, there is chronicity, especially affecting the elderly, which is dealt with by other workers (nurses, private family assistants, social workers) who care patients at home and replace physicians. The general practitioners’ work is difficult because of many different reasons; but the central theme is the lack of absolute power – based on morality and consciousness – which leads to the perception of catastrophic consequences for medical profession and the physician-patient relationship. Often, general practitioners are in their offices and are not able to go to patients’ home, therefore they cannot create care relationships based on trust and dependence which allow useful and trustworthy interventions. In sum, the core theme emerging from data refers to the general practitioners’ perceived lack of personal and trust-based relationships with patients

Rashba interaction in quantum wires with in-plane magnetic fields

We analyze the spectral and transport properties of ballistic quasi one-dimensional systems in the presence of spin-orbit coupling and in-plane agnetic fields. Our results demonstrate that Rashba precession and intersubband coupling must be treated on equal footing for wavevectors near the magnetic field induced gaps. We find that intersubband coupling limits the occurrence of negative effective masses at the gap edges and modifies the linear conductance curves in the strong coupling limit. The effect of the magnetic field on the spin textured orientation of the wire magnetization is discussed.Comment: 6 pages, 6 figures; new figures, discussion extende

Urban Deforestation and Urban Development

This paper has developed a model of a single forest owner operating with perfect foresight in a dynamic open-city environment that allows for switching between alternative competing land uses (forest and urban use) at some point in the future. The model also incorporates external values of an even-aged standing forest in addition to the value of timber when it is harvested. Timber is exploited based on a multiple rotation model a la Faustmann with clear-cut harvesting. In contrast to previous models, our alternative land use to forest land is endogenous. Within this framework, we study the problem of the private owner as well as that of the social planner, when choosing the time to harvest, the time to convert land and the intensity of development. We also examine the extent to which the two-way linkage between urban development and forest management practices (timber production and provision of forest amenities) contributes to economic efficiency and improvements in non-market forest benefits. Finally, we consider policy options available to a regulator seeking to achieve improvements in efficiency including anti-sprawl policies (impact fees and density controls) and forest policies such a yield tax. Numerical simulations illustrate our analytical results. JEL codes:Deforestation, Urban Development, Forest Management Practices, Anti-Sprawl Policies, Yield Taxes