571 research outputs found
A Novel Approach to Reduction of Frictional Losses in a Heavy-Duty Diesel Engine by Reducing the Hydrodynamic Frictional Losses
An important parameter in the reduction of fuel consumption of heavy-duty diesel engines is the Power Cylinder Unit (PCU); the PCU is the single largest contributor to engine frictional losses. Much attention, from both academia and industry, has been paid to reducing the frictional losses of the PCU in the boundary and mixed lubrication regime. However, previous studies have shown that a large portion of frictional losses in the PCU occur in the hydrodynamic lubrication regime. A novel texturing design with large types of surface features was experimentally analyzed using a tribometer setup. The experimental result shows a significant reduction of friction loss for the textured surfaces. Additionally, the textured surface did not exhibit wear. On the contrary, it was shown that the textured surfaces exhibited a smaller amount of abrasive scratches on the plateaus (compared to the reference plateau honed surface) due to entrapment of wear particles within the textures. The decrease in hydrodynamic friction for the textured surfaces relates to the relative increase of oil film thickness within the textures. A tentative example is given which describes a method of decreasing hydrodynamic frictional losses in the full-scale application
Biomarkers of neuronal damage in saturation diving-a controlled observational study
PURPOSE: A prospective and controlled observational study was performed to determine if the central nervous system injury markers glial fibrillary acidic protein (GFAp), neurofilament light (NfL) and tau concentrations changed in response to a saturation dive. METHODS: The intervention group consisted of 14 submariners compressed to 401 kPa in a dry hyperbaric chamber. They remained pressurized for 36 h and were then decompressed over 70 h. A control group of 12 individuals was used. Blood samples were obtained from both groups before, during and after hyperbaric exposure, and from the intervention group after a further 25-26 h. RESULTS: There were no statistically significant changes in the concentrations of GFAp, NfL and tau in the intervention group. During hyperbaric exposure, GFAp decreased in the control group (mean/medianâ-â15.1/â-â8.9 pg·mL-1, pâ<â0.01) and there was a significant difference in absolute change of GFAp and NfL between the groups (17.7 pg·mL-1, pâ=â0.02 and 2.34 pg·mL-1, pâ=â0.02, respectively). Albumin decreased in the control group (mean/medianâ-â2.74 g/L/â-â0.95 g/L, pâ=â0.02), but there was no statistically significant difference in albumin levels between the groups. In the intervention group, haematocrit and mean haemoglobin values were slightly increased after hyperbaric exposure (mean/median 2.3%/1.5%, pâ=â0.02 and 4.9 g/L, pâ=â0.06, respectively). CONCLUSION: Hyperbaric exposure to 401 kPa for 36 h was not associated with significant increases in GFAp, NfL or tau concentrations. Albumin levels, changes in hydration or diurnal variation were unlikely to have confounded the results. Saturation exposure to 401 kPa seems to be a procedure not harmful to the central nervous system. TRIAL REGISTRATION: ClinicalTrials.gov NCT03192930
Evaluation of a Commercial Enzyme Linked Immunosorbent Assay (ELISA) for the Determination of the Neurotoxin BMAA in Surface Waters
The neurotoxin Ă-N-methylamino-L-alanine (BMAA) is suspected to play a role in Alzheimerâs disease, Parkinsonâs disease and amyotrophic lateral sclerosis. Because BMAA seems to be produced by cyanobacteria, surface waters are screened for BMAA. However, reliable analysis of BMAA requires specialized and expensive equipment. In 2012, a commercial enzyme-linked immunosorbent assay (ELISA) for determination of BMAA in surface waters was released. This kit could enable fast and relatively cheap screening of surface waters for BMAA. The objective of this study was to determine whether the BMAA ELISA kit was suitable for the determination of BMAA concentrations in surface waters. We hypothesised that the recovery of spiked samples was close to 100% and that the results of unspiked sample analysis were comparable between ELISA and liquid chromatography tandem mass spectrometry (LC-MS/MS) analysis. However, we found that recovery was higher than 100% in most spiked samples, highest determined recovery was over 400%. Furthermore, the ELISA gave a positive signal for nearly each tested sample while no BMAA could be detected by LC-MS/MS. We therefore conclude that in its current state, the kit is not suitable for screening surface waters for BMAA
Electroencephalography (EEG) for neurological prognostication after cardiac arrest and targeted temperature management; rationale and study design.
BACKGROUND: Electroencephalography (EEG) is widely used to assess neurological prognosis in patients who are comatose after cardiac arrest, but its value is limited by varying definitions of pathological patterns and by inter-rater variability. The American Clinical Neurophysiology Society (ACNS) has recently proposed a standardized EEG-terminology for critical care to address these limitations.
METHODS/DESIGN: In the TTM-trial, 399 post cardiac arrest patients who remained comatose after rewarming underwent a routine EEG. The presence of clinical seizures, use of sedatives and antiepileptic drugs during the EEG-registration were prospectively documented.
DISCUSSION: A well-defined terminology for interpreting post cardiac arrest EEGs is critical for the use of EEG as a prognostic tool.
TRIAL REGISTRATION: The TTM-trial is registered at ClinicalTrials.gov (NCT01020916)
Effects of whole grain rye crisp bread for breakfast on appetite and energy intake in a subsequent meal: two randomised controlled trails with different amounts of test foods and breakfast energy content
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