A View from the Top: International Politics, Norms and the Worldwide Growth of NGOs

This article provides a top-down explanation for the rapid growth of nongovernmental organizations (NGOs) in the postwar period, focusing on two aspects of political globalization. First, I argue that international political opportunities in the form of funding and political access have expanded enormously in the postwar period and provided a structural environment highly conducive to NGO growth. Secondly, I present a norm-based argument and trace the rise of a pro-NGO norm in the 1980s and 1990s among donor states and intergovernmental organizations (IGOs), which has actively promoted the spread of NGOs to non-Western countries. The article ends with a brief discussion of the symbiotic relationship among NGOs, IGOs, and states promoting international cooperation

The altruistic lobbyists

The role of non-governmental organizations (NGOs) has sparked increased interest in recent years as they have grown in prominence and international activity. The thesis looks at British and Canadian NGOs concerned with overseas development assistance, and asks what influence they have wielded in the formulation of their own governments' development policies. Based on recent policy community writing, a "conceptual map" is devised which suggests that six elements are important for any analysis of influence: context, content, motivations, resources, tactics, and channels. Chapters two to five use these elements to look at the broad "policy communities" in which official development policy is formulated, and to examine the increasing roles and activities of NGOs as lobbyists. Chapters six and seven take a closer look at two specific "policy networks" within those communities: the relationships created around the World Food Conference in 1974 are compared with those existing at the time of the 1992 United Nations Conference on Environment and Development (the Earth Summit). The thesis concludes that NGOs have had an increasing but limited influence on government policy, given (1) an increase in the activity and influence of NGOs, (2) the greater relevance of certain "elements of influence" over others, and (3) the comparatively stronger influence of Canadian NGOs in relation to their British counterparts. The thesis' contribution to knowledge is based on its use of extensive and original primary sources and interviews in both countries, its application of a policy community approach to a new field in international relations, and its systematic attempt to answer evolving questions about this growing, international, and non-governmental force

Nanofiber-based delivery of therapeutic peptides to the brain

The delivery of therapeutic peptides and proteins to the central nervous system is the biggest challenge when developing effective neuropharmaceuticals. The central issue is that the blood-brain barrier is impermeable to most molecules. Here we demonstrate the concept of employing an amphiphilic derivative of a peptide to deliver the peptide into the brain. The key to success is that the amphiphilic peptide should by design self-assemble into nanofibers wherein the active peptide epitope is tightly wrapped around the nanofiber core. The nanofiber form appears to protect the amphiphilic peptide from degradation while in the plasma, and the amphiphilic nature of the peptide promotes its transport across the blood-brain barrier. Therapeutic brain levels of the amphiphilic peptide are achieved with this strategy, compared with the absence of detectable peptide in the brain and the consequent lack of a therapeutic response when the underivatized peptide is administered