Factors associated with estimated parasite load in blood of <i>T</i>. <i>cruzi</i>-infected mothers at the time of delivery.

<p>The limit of detection for the quantitative PCR assay was 1 parasite/mL. Parasite load values below this cutoff were assumed to be 0 for the purpose of analysis.</p><p>^aqPCR data were missing for 2 women who transmitted and 6 women who did not transmit to their infants. Four mother-infant pairs with ambiguous transmission status are excluded (see text).</p><p>^bComparison of parasite load distributions by maternal characteristic by Wilcoxon signed rank test.</p><p>^cComparison of years of exposure by parasite load category by Kruskal-Wallis test.</p><p>Factors associated with estimated parasite load in blood of <i>T</i>. <i>cruzi</i>-infected mothers at the time of delivery.</p

Maternal factors associated with congenital <i>Trypanosoma cruzi</i> transmission risk.

<p>The limit of detection for the quantitative PCR assay was 1 parasite/mL. Parasite load values below this cutoff were assumed to be 0 for the purpose of analysis.</p><p>^aqPCR data were missing for 2 women who transmitted and 6 women who did not transmit to their infants. Four mother-infant pairs with ambiguous transmission status are excluded (see text).</p><p>Maternal factors associated with congenital <i>Trypanosoma cruzi</i> transmission risk.</p

Comparison of biomarkers and biomarker ratios in <i>T. cruzi</i>-infected (Tc+) vs uninfected (Tc−) subjects by stage.

<p>Bolded values represent a significant difference between Tc+ or Tc− individuals at a p<0.05.</p><p>Comparison of biomarkers and biomarker ratios in <i>T. cruzi</i>-infected (Tc+) vs uninfected (Tc−) subjects by stage.</p

Logistic regression comparing biomakers and biomarker ratios by cardiac stage among <i>T-cruzi</i> infected (Tc+) individuals. Cutoffs were determined by ROC analysis.

<p>*Multivariate analyses adjusted for age, sex, and presence of comorbidities (hypertension, diabetes, and coronary artery disease).</p><p>Logistic regression comparing biomakers and biomarker ratios by cardiac stage among <i>T-cruzi</i> infected (Tc+) individuals. Cutoffs were determined by ROC analysis.</p

Results of ROC analysis of selected markers for discrimination between Stage AB and CD among <i>T. cruzi</i>-infected individuals.

<p>Results of ROC analysis of selected markers for discrimination between Stage AB and CD among <i>T. cruzi</i>-infected individuals.</p

Demographic, electrocardiographic, and echocardiographic findings by stage in <i>T. cruzi</i>-infected (Tc+) and uninfected (Tc−) individuals.

<p>Bolded values represent a significant difference between Tc+ or Tc− individuals at a p<0.05.</p><p>*Not all individuals had echocardiography performed; Ns shown in <a href="http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0003227#pntd-0003227-g001" target="_blank">Figure 1</a>.</p><p>bpm = beats per minute, ms = millisecond, AV = atrio-ventricular, RBBB = right bundle branch block, LAFB = left anterior fascicular block, LBBB = left bundle branch block, EF = ejection fraction. LVEDD = left ventricular end diastolic diameter. na = not applicable.</p><p>Demographic, electrocardiographic, and echocardiographic findings by stage in <i>T. cruzi</i>-infected (Tc+) and uninfected (Tc−) individuals.</p