Lithium Ion Nanocarriers Self-Assembled from Amphiphiles with Aggregation-Induced Emission Activity

Lithium salts are extensively used to treat diseases such as bipolar disorder or chronic reduction, but they often trigger undesirable side effects in patients due to the accumulation of lithium ions in peripheral organs. A conventional strategy for fabricating nanocarriers is not applicable to lithium ions because of their difficulty in binding firmly to molecules in water and easy leakage due to their small size and high water solubility. We report here the successful fabrication of lithium ion nanocarriers in water with an amphiphile containing two ethylene oxide tetramers attached to a hydrophobic core showing aggregation-induced light emission (AIE). The amphiphile self-assembles into fluorescent spherical aggregates in water. Lithium ions are loaded into the spherical aggregates by binding to the ethylene oxide tetramer. This nanocarrier can enter cells facilely via an endocytosis process and does not affect the cell viability at concentrations of up to 100 μM. Moreover, the self-imaging ability of the nanocarriers can be used to track the location of lithium-based drugs. We expect that this strategy of fabricating lithium nanocarriers will pave the way for reducing the practical doses of lithium salt that are used in clinical therapy

Coordination-Triggered Hierarchical Folate/Zinc Supramolecular Hydrogels Leading to Printable Biomaterials

Printable hydrogels desired in bioengineering have extremely high demands on biocompatibility and mechanic strength, which can hardly be achieved in conventional hydrogels made with biopolymers. Here, we show that on employment of the strategy of coordination-triggered hierarchical self-assembly of naturally occurring small-molecule folic acid, supramolecular hydrogels with robust mechanical elastic modulus comparable to synthetic double-network polymer gels can be made at concentrations below 1%. A sequence of hierarchical steps are involved in the formation of this extraordinary hydrogel: petrin rings on folate form tetramers through hydrogen bonding, tetramers stack into nanofibers by π–π stacking, and zinc ions cross-link the nanofibers into larger-scale fibrils and further cross-link the fibril network to gel water. These supramolecular qualities endow the hydrogel with shear-thinning and instant healing ability, which makes the robust gel injectable and printable into various three-dimensional structures. Owing to the excellent biocompatibility, the gel can support cells three-dimensionally and can be used as an ideal carrier for imaging agent (Gd³⁺), as well as chemodrugs. In combination with its easy formation and abundant sources, this newly discovered metallo-folate supramolecular hydrogel is promising in various bioengineering technological applications

A Hydrogel Electrolyte toward a Flexible Zinc-Ion Battery and Multifunctional Health Monitoring Electronics

The compact design of an environmentally adaptive battery and effectors forms the foundation for wearable electronics capable of time-resolved, long-term signal monitoring. Herein, we present a one-body strategy that utilizes a hydrogel as the ionic conductive medium for both flexible aqueous zinc-ion batteries and wearable strain sensors. The poly(vinyl alcohol) hydrogel network incorporates nano-SiO2 and cellulose nanofibers (referred to as PSC) in an ethylene glycol/water mixed solvent, balancing the mechanical properties (tensile strength of 6 MPa) and ionic diffusivity at −20 °C (2 orders of magnitude higher than 2 M ZnCl2 electrolyte). Meanwhile, cathode lattice breathing during the solvated Zn2+ intercalation and dendritic Zn protrusion at the anode interface are mitigated. Besides the robust cyclability of the Zn∥PSC∥V2O5 prototype within a wide temperature range (from −20 to 80 °C), this microdevice seamlessly integrates a zinc-ion battery with a strain sensor, enabling precise monitoring of the muscle response during dynamic body movement. By employing transmission-mode operando XRD, the self-powered sensor accurately documents the real-time phasic evolution of the layered cathode and synchronized strain change induced by Zn deposition, which presents a feasible solution of health monitoring by the miniaturized electronics

A Hydrogel Electrolyte toward a Flexible Zinc-Ion Battery and Multifunctional Health Monitoring Electronics

The compact design of an environmentally adaptive battery and effectors forms the foundation for wearable electronics capable of time-resolved, long-term signal monitoring. Herein, we present a one-body strategy that utilizes a hydrogel as the ionic conductive medium for both flexible aqueous zinc-ion batteries and wearable strain sensors. The poly(vinyl alcohol) hydrogel network incorporates nano-SiO2 and cellulose nanofibers (referred to as PSC) in an ethylene glycol/water mixed solvent, balancing the mechanical properties (tensile strength of 6 MPa) and ionic diffusivity at −20 °C (2 orders of magnitude higher than 2 M ZnCl2 electrolyte). Meanwhile, cathode lattice breathing during the solvated Zn2+ intercalation and dendritic Zn protrusion at the anode interface are mitigated. Besides the robust cyclability of the Zn∥PSC∥V2O5 prototype within a wide temperature range (from −20 to 80 °C), this microdevice seamlessly integrates a zinc-ion battery with a strain sensor, enabling precise monitoring of the muscle response during dynamic body movement. By employing transmission-mode operando XRD, the self-powered sensor accurately documents the real-time phasic evolution of the layered cathode and synchronized strain change induced by Zn deposition, which presents a feasible solution of health monitoring by the miniaturized electronics

A Hydrogel Electrolyte toward a Flexible Zinc-Ion Battery and Multifunctional Health Monitoring Electronics

The compact design of an environmentally adaptive battery and effectors forms the foundation for wearable electronics capable of time-resolved, long-term signal monitoring. Herein, we present a one-body strategy that utilizes a hydrogel as the ionic conductive medium for both flexible aqueous zinc-ion batteries and wearable strain sensors. The poly(vinyl alcohol) hydrogel network incorporates nano-SiO2 and cellulose nanofibers (referred to as PSC) in an ethylene glycol/water mixed solvent, balancing the mechanical properties (tensile strength of 6 MPa) and ionic diffusivity at −20 °C (2 orders of magnitude higher than 2 M ZnCl2 electrolyte). Meanwhile, cathode lattice breathing during the solvated Zn2+ intercalation and dendritic Zn protrusion at the anode interface are mitigated. Besides the robust cyclability of the Zn∥PSC∥V2O5 prototype within a wide temperature range (from −20 to 80 °C), this microdevice seamlessly integrates a zinc-ion battery with a strain sensor, enabling precise monitoring of the muscle response during dynamic body movement. By employing transmission-mode operando XRD, the self-powered sensor accurately documents the real-time phasic evolution of the layered cathode and synchronized strain change induced by Zn deposition, which presents a feasible solution of health monitoring by the miniaturized electronics

Self-Assembly-Triggered Cis-to-Trans Conversion of Azobenzene Compounds

Cis-to-trans transition of azobenzene compounds usually occurs under appropriate light irradiation or slow thermal relaxation, and one can hardly obtain complete cis-to-trans transition of azos due to the overlap of the <i>n-π*</i> transition of the trans and the cis isomers. We show that by viewing the photostationary state as a chemical equilibrium between the cis and trans isomers, triggered self-assembly of the trans isomers can promote the cis-to-trans transition, and trans azos with spectrum-grade purity can even be achieved using an elegantly designed coordinating azo. This work establishes a new paradigm for manipulating the cis-to-trans transition of azo compounds, which may inspire designs for various azo-based advanced materials

Allosteric Self-Assembly of Coordinating Terthiophene Amphiphile for Triggered Light Harvesting

Allosteric regulation is extensively employed by nature to achieve functional control of protein or deoxyribonucleic acid through triggered conformational change at a remote site. We report that a similar strategy can be utilized in artificial self-assembly to control the self-assembled structure and its function. We show that on binding of metal ions to the headgroup of an amphiphile TTC4L, the conformational change may lead to change of the dipole orientation of the energy donor at the chain end. This on the one hand leads to a drastically different self-assembled structure; on the other hand, it enables light harvesting between the donor–acceptor. Because the Forster resonance fluorescence transfer efficiency is gated by metal ions, controlling the feeding of metal ions allows switching on and off of light harvesting. We expect that using allosteric self-assembly, we will be able to create abundant structures with distinct function from limited molecules, which show prominent potential for the postorganic modification of the structure and function of self-assembled materials