Dynamic Prototype Mask for Occluded Person Re-Identification

Although person re-identification has achieved an impressive improvement in recent years, the common occlusion case caused by different obstacles is still an unsettled issue in real application scenarios. Existing methods mainly address this issue by employing body clues provided by an extra network to distinguish the visible part. Nevertheless, the inevitable domain gap between the assistant model and the ReID datasets has highly increased the difficulty to obtain an effective and efficient model. To escape from the extra pre-trained networks and achieve an automatic alignment in an end-to-end trainable network, we propose a novel Dynamic Prototype Mask (DPM) based on two self-evident prior knowledge. Specifically, we first devise a Hierarchical Mask Generator which utilizes the hierarchical semantic to select the visible pattern space between the high-quality holistic prototype and the feature representation of the occluded input image. Under this condition, the occluded representation could be well aligned in a selected subspace spontaneously. Then, to enrich the feature representation of the high-quality holistic prototype and provide a more complete feature space, we introduce a Head Enrich Module to encourage different heads to aggregate different patterns representation in the whole image. Extensive experimental evaluations conducted on occluded and holistic person re-identification benchmarks demonstrate the superior performance of the DPM over the state-of-the-art methods. The code is released at https://github.com/stone96123/DPM.Comment: Accepted by ACM MM 202

Orientation-Aware 3D SLAM in Alternating Magnetic Field from Powerlines

Identifying new sensing modalities for indoor localization is an interest of research. This paper studies powerline-induced alternating magnetic field (AMF) that fills the indoor space for the orientation-aware three-dimensional (3D) simultaneous localization and mapping (SLAM). While an existing study has adopted a uniaxial AMF sensor for SLAM in a plane surface, the design falls short of addressing the vector field nature of AMF and is therefore susceptible to sensor orientation variations. Moreover, although the higher spatial variability of AMF in comparison with indoor geomagnetism promotes location sensing resolution, extra SLAM algorithm designs are needed to achieve robustness to trajectory deviations from the constructed map. To address the above issues, we design a new triaxial AMF sensor and a new SLAM algorithm that constructs a 3D AMF intensity map regularized and augmented by a Gaussian process. The triaxial sensor’s orientation estimation is free of the error accumulation problem faced by inertial sensing. From extensive evaluation in eight indoor environments, our AMF-based 3D SLAM achieves sub-1m to 3m median localization errors in spaces of up to 500 m2 , sub-2° mean error in orientation sensing, and outperforms the SLAM systems based on Wi-Fi, geomagnetism, and uniaxial AMF by more than 30%

Full length talin stimulates integrin activation and axon regeneration.

Integrin function is regulated by activation involving conformational changes that modulate ligand-binding affinity and downstream signaling. Activation is regulated through inside-out signaling which is controlled by many signaling pathways via a final common pathway through kindlin and talin, which bind to the intracellular tail of beta integrins. Previous studies have shown that the axon growth inhibitory molecules NogoA and chondroitin sulfate proteoglycans (CSPGs) inactivate integrins. Overexpressing kindlin-1 in dorsal root ganglion (DRG) neurons activates integrins, enabling their axons to overcome inhibitory molecules in the environment, and promoting regeneration in vivo following dorsal root crush. Other studies have indicated that expression of the talin head alone or with kindlin can enhance integrin activation. Here, using adult rat DRG neurons, we investigate the effects of overexpressing various forms of talin on axon growth and integrin signaling. We found that overexpression of the talin head activated axonal integrins but inhibited downstream signaling via FAK, and did not promote axon growth. Similarly, co-expression of the talin head and kindlin-1 prevented the growth-promoting effect of kindlin-1, suggesting that the talin head acts as a form of dominant negative for integrin function. Using full-length talin constructs in PC12 cells we observed that neurite growth was enhanced by the expression of wild-type talin and more so by two 'activated' forms of talin produced by point mutation (on laminin and aggrecan-laminin substrates). Nevertheless, co-expression of full-length talin with kindlin did not promote neurite growth more than either molecule alone. In vivo, we find that talin is present in PNS axons (sciatic nerve), and also in CNS axons of the corticospinal tract.This work was funded by grants from the Medical Research Council (G1000864), the Henry Smith Charity, the Christopher and Dana Reeve Foundation, the John and Lucille van Geest Foundation, the European Union Framework 7 Programmes Spinal Cord Repair (201144) and Plasticise (223524), and the NIHR Cambridge Biomedical Research Centre. CLT was supported by the Merck, Sharpe and Dohme Fund. We thank Rienhardt Fassler for kindlin constructs and advice, David Critchley for talin antibodies and constructs and Mark Ginsberg for talin constructs.This is the final version of the article. It first appeared from Elsevier via http://dx.doi.org/10.1016/j.mcn.2015.03.01

Exergetic and parametric study of a solar aided coal-fired power plant

A solar-aided coal-fired power plant realizes the integration of a fossil fuel (coal or gas) and clean energy (solar). In this paper, a conventional 600 MW coal-fired power plant and a 600 MW solar-aided coal-fired power plant have been taken as the study case to understand the merits of solar-aided power generation (SAPG) technology. The plants in the case study have been analyzed by using the First and Second Laws of Thermodynamics principles. The solar irradiation and load ratio have been considered in the analysis. We conclude that if the solar irradiation was 925 W/m2 and load ratio of the SAPG plant was 100%, the exergy efficiency would be 44.54% and the energy efficiency of the plant (46.35%). It was found that in the SAPG plant the largest exergy loss was from the boiler, which accounted for about 76.74% of the total loss. When the load ratio of the unit remains at 100%, and the solar irradiation varies from 500 W/m2 to 1,100 W/m2, the coal savings would be in the range of 8.6 g/kWh to 15.8 g/kWh. If the solar irradiation were kept at 925 W/m2 while the load ratio of the plant changed from 30% to 100%, the coal savings could be in the range of 11.99 g/kWh to 13.75 g/kWh.Rongrong Zhai, Yong Zhu, Yongping Yang, Kaiyu Tan and Eric H

How early can myocardial iron overload occur in Beta thalassemia major?

BACKGROUND: Myocardial siderosis is the most common cause of death in patients with beta thalassemia major(TM). This study aimed at investigating the occurrence, prevalence and severity of cardiac iron overload in a young Chinese population with beta TM. METHODS AND RESULTS: We analyzed T2* cardiac magnetic resonance (CMR), left ventricular ejection fraction (LVEF) and serum ferritin (SF) in 201 beta TM patients. The median age was 9 years old. Patients received an average of 13 units of blood per year. The median SF level was 4536 ng/ml and 165 patients (82.1%) had SF>2500 ng/ml. Myocardial iron overload was detected in 68 patients (33.8%) and severe myocardial iron overload was detected in 26 patients (12.6%). Twenty-two patients ≤10 years old had myocardial iron overload, three of whom were only 6 years old. No myocardial iron overload was detected under the age of 6 years. Median LVEF was 64% (measured by CMR in 175 patients). Five of 6 patients with a LVEF<56% and 8 of 10 patients with cardiac disease had myocardial iron overload. CONCLUSIONS: The TM patients under follow-up at this regional centre in China patients are younger than other reported cohorts, more poorly-chelated, and have a high burden of iron overload. Myocardial siderosis occurred in patients younger than previously reported, and was strongly associated with impaired LVEF and cardiac disease. For such poorly-chelated TM patients, our data shows that the first assessment of cardiac T2* should be performed as early as 6 years old

CD36 Participates in PrP106–126-Induced Activation of Microglia

Microglial activation is a characteristic feature of the pathogenesis of prion diseases. The molecular mechanisms that underlie prion-induced microglial activation are not very well understood. In the present study, we investigated the role of the class B scavenger receptor CD36 in microglial activation induced by neurotoxic prion protein (PrP) fragment 106–126 (PrP106–126). We first examined the time course of CD36 mRNA expression upon exposure to PrP106–126 in BV2 microglia. We then analyzed different parameters of microglial activation in PrP106–126-treated cells in the presence or not of anti-CD36 monoclonal antibody (mAb). The cells were first incubated for 1 h with CD36 monoclonal antibody to block the CD36 receptor, and were then treated with neurotoxic prion peptides PrP106–126. The results showed that PrP106–126 treatment led to a rapid yet transitory increase in the mRNA expression of CD36, upregulated mRNA and protein levels of proinflammatory cytokines (IL-1β, IL-6 and TNF-α), increased iNOS expression and nitric oxide (NO) production, stimulated the activation of NF-κB and caspase-1, and elevated Fyn activity. The blockade of CD36 had no effect on PrP106–126-stimulated NF-κB activation and TNF-α protein release, abrogated the PrP106–126-induced iNOS stimulation, downregulated IL-1β and IL-6 expression at both mRNA and protein levels as well as TNF-α mRNA expression, decreased NO production and Fyn phosphorylation, reduced caspase-1 cleavage induced by moderate PrP106–126 –treatment, but had no effect on caspase-1 activation after treatment with a high concentration of PrP106–126. Together, these results suggest that CD36 is involved in PrP106–126-induced microglial activation and that the participation of CD36 in the interaction between PrP106–126 and microglia may be mediated by Src tyrosine kinases. Our findings provide new insights into the mechanisms underlying the activation of microglia by neurotoxic prion peptides and open perspectives for new therapeutic strategies for prion diseases by modulation of CD36 signaling

Tropical data centre proof-of-concept

Singapore is a data center (DC) hub in Southeast Asia. However, Singapore's year-round high temperatures and humidity levels introduce significant challenges for the local DC operators in improving the energy efficiency of their infrastructures. As Singapore's DCs spend more energy in cooling, their average power usage effectiveness (PUE), which is 2.07, is higher than the global average of 1.7. In the United States, the DC sector accounted for 1.8% of the country's total electricity consumption in 2014. In Singapore, this percentage is up to 7%. Thus, technologies that can improve DC energy efficiency in the tropics will further enhance Singapore's attractiveness as a regional data center hub. They are also important to Singapore's energy sustainability and commitment to Paris Agreement. Air-side free cooling that utilizes outside cold air to cool the information technology (IT) equipment has been increasingly used to improve the energy efficiency of DCs. However, air-side free cooling in the tropics has been long thought infeasible from the intuition that the high temperature and relative humidity (RH) of the air supplied to the servers will undermine their performance and reliability. On the other hand, the American Society of Heating, Refrigeration and Air-Conditioning Engineers (ASHRAE) has been working for years on expanding its suggested allowable temperature and RH ranges for IT equipment. For instance, the servers compliant with ASHRAE's Class A3 can operate continuously and reliably when the temperature and RH of the supply air are up to 40 degree Celsius and 90%. This sheds light on the possibility of air-side free-cooled DCs in Singapore, since the record temperature in Singapore is 37 degree Celsius only and the ambient RH is in general lower than 90%. To investigate the feasibility of air-side free cooling in Singapore, together with multiple partners in DC industry and research, we designed, constructed, and experimented with an air-side free-cooled DC testbed consisting of three server rooms located in two local DC operators' premises. The testbed hosts 12 server racks with 60kW total power rating. This technical report holistically introduces this project, presents the measurement results, discusses the experiences and learned lessons obtained from the project

Real-time cooling power attribution for co-located data center rooms with distinct temperatures and humidities

At present, a co-location data center often applies an identical and low temperature setpoint for its all server rooms. Although increasing the temperature setpoint is a rule-of-thumb approach to reducing the cooling energy usage, the tenants may have different mentalities and technical constraints in accepting higher temperature setpoints. Thus, supporting distinct temperature setpoints is desirable for a co-location data center in pursuing higher energy efficiency. This calls for a new cooling power attribution scheme to address the inter-room heat transfers that can be up to 9% of server load as shown in our real experiments. This article describes our approaches to estimating the inter-room heat transfers, using the estimates to rectify the metered power usages of the rooms' air handling units, and fairly attributing the power usage of the shared cooling infrastructure (i.e., chiller and cooling tower) to server rooms by following the Shapley value principle. Extensive numeric experiments based on a widely accepted cooling system model are conducted to evaluate the effectiveness of the proposed cooling power attribution scheme. A case study suggests that the proposed scheme incentivizes rational tenants to adopt their highest acceptable temperature setpoints under a non-cooperative game setting. Further analysis considering distinct relative humidity setpoints shows that our proposed scheme also properly and inherently addresses the attribution of humidity control power.National Research Foundation (NRF)This project was supported by the National Research Foundation, Singapore, funded under the Energy Research Test-Bed and Industry Partnership Funding Initiative, part of the Energy Grid (EG) 2.0 program

Coupling Coordination Relationship and Driving Mechanism between Urbanization and Ecosystem Service Value in Large Regions: A Case Study of Urban Agglomeration in Yellow River Basin, China

Mastering the coupling and coordination relationship and driving mechanism of urbanization and ecosystem service value (ESV) is of great significance to ecological protection and regional sustainable development. In this paper, the coupling coordination model, geographic detector and GWR model are used to analyze the spatio-temporal coupling interaction between urbanization and ESV and the spatial differentiation characteristics of influencing factors from 1995 to 2018. The results of the study are as follows: (1) During the study period, cities in the Yellow River Basin experienced accelerated urban expansion, and the ESV of forests, water and wetlands increased, which offset the reduction in ESV due to the expansion of construction land and farmland and grassland. (2) The degree of coupling and coordination between the two gradually improved, but the overall situation showed a low-level coupling and coordination process. Mild coupling coordination gradually increased, reaching an increase of 38.10%; severe imbalance types tended to disappear, decreasing by 52.38%, and coupling subtypes developed from lagging urbanization to ESV backward types. The high-value areas of the coupling coordination degree are distributed in the high-value areas of ESV in the north of the upper reaches, and the low-value areas are distributed in the cities of Henan and Shandong with high urbanization levels in the downstream and most resource-based cities in the middle reaches. (3) In addition, the spatial intensity of the effect of each dominant factor on the degree of coupling coordination is different. Economic growth, technological development, environmental regulations and the proportion of forest land have positive and belt-shaped alienation characteristics for the coupling and coordination of the two, and infrastructure and temperature show negative driving characteristics. Therefore, the coupling and coordination relationship between ESV and urbanization should be clarified to help future urban planning. On the basis of determining the regional environmental carrying capacity and the adjustment direction of the rational planning of land resources, the impact of urban barriers formed by administrative boundaries and natural geographical conditions on the development of urban agglomerations should be broken to achieve the overall high-quality and coordinated development of the basin