Towards Adaptive Semantic Segmentation by Progressive Feature Refinement

As one of the fundamental tasks in computer vision, semantic segmentation plays an important role in real world applications. Although numerous deep learning models have made notable progress on several mainstream datasets with the rapid development of convolutional networks, they still encounter various challenges in practical scenarios. Unsupervised adaptive semantic segmentation aims to obtain a robust classifier trained with source domain data, which is able to maintain stable performance when deployed to a target domain with different data distribution. In this paper, we propose an innovative progressive feature refinement framework, along with domain adversarial learning to boost the transferability of segmentation networks. Specifically, we firstly align the multi-stage intermediate feature maps of source and target domain images, and then a domain classifier is adopted to discriminate the segmentation output. As a result, the segmentation models trained with source domain images can be transferred to a target domain without significant performance degradation. Experimental results verify the efficiency of our proposed method compared with state-of-the-art methods

Stressed waveguides with tubular depressed-cladding inscribed in phosphate glasses by femtosecond hollow laser beams

This is the published version. ©Copyright 2012 Optical Society of AmericaWe report on the single-step fabrication of stressed optical waveguides with tubular depressed-refractive-index cladding in phosphate glasses by the use of focused femtosecond hollow laser beams. Tubelike low index regions appear under direct exposure due to material rarefaction following expansion. Strained compacted zones emerged in domains neighboring the tubular track of lower refractive index, and waveguiding occurs mainly within the tube core fabricated by the engineered femtosecond laser beam. The refractive index profile of the optical waveguide was reconstructed from the measured transmitted near-field intensity

Chlorido{2-[1-(2-pyridylmethyl­imino)eth­yl]pyrrolato-κ3 N,N′,N′′}copper(II)

The potential tridentate Schiff base ligand 2-[1-(2-pyridyl­methyl­imino)eth­yl]pyrrole (HL) was synthesized from the condensation of 2-acetyl­pyrrole with 2-amino­methyl­pyridine. The title compound, [Cu(C12H12N3)Cl], was synthesized from HL and copper(II) chloride using triethyl­amine as a base to deprotonate the pyrrole NH group. The title compound is a monomer and the central copper(II) ion is bound to three N atoms of the deprotonated tridentate ligand and to one chloride ion in a square-planar N3Cl coordination

Risk factors of oncogenic HPV infection in HIV-positive men with anal condyloma acuminata in Shenzhen, Southeast China: a retrospective cohort study

BackgroundHuman immunodeficiency virus (HIV)-positive patients with anal condyloma acuminata (CA) present an increased risk of anal cancer progression associated with oncogenic human papillomavirus (HPV) infection. It is essential to explore determinants of anal infection by oncogenic HPV among HIV-positive patients with CA.MethodsA retrospective cohort study was performed in HIV-positive patients with CA between January 2019 to October 2021 in Shenzhen, Southeast China. Exfoliated cells were collected from CA lesions and the anal canal of HPV genotypes detected by fluorescence PCR. Unconditional logistic regression analysis was used to probe associations of independent variables with oncogenic HPV infection.ResultsAmong HIV-positive patients with CA, the most prevalent oncogenic genotypes were HPV52 (29.43%), HPV16 (28.93%), HPV59 (19.20%), and HPV18 (15.96%). Risk of oncogenic HPV infection increased with age at enrollment (COR: 1.04, 95% CI: 1.01–1.07, p = 0.022). In the multivariable analysis, age ≥ 35 years (AOR: 2.56, 95% CI: 1.20–5.70, p = 0.02) and history of syphilis (AOR: 3.46, 95% CI: 1.90–6.79, p < 0.01) were independent risk factors statistically associated with oncogenic HPV infection. History of syphilis (AOR: 1.72, 95% CI: 1.08–2.73, p < 0.02) was also an independent risk factor statistically associated with HPV16 or HPV18 infection.ConclusionIn clinical practice, HIV-positive CA patients aged ≥35 years or with a history of syphilis should carry out HR-HPV testing and even anal cancer-related examinations to prevent the occurrence of anal cancer

An Assessment of Multimodel Simulations for the Variability of Western North Pacific Tropical Cyclones and Its Association with ENSO

An assessment of simulations of the interannual variability of tropical cyclones (TCs) over the western North Pacific (WNP) and its association with El Niño–Southern Oscillation (ENSO), as well as a subsequent diagnosis for possible causes of model biases generated from simulated large-scale climate conditions, are documented in the paper. The model experiments are carried out by the Hurricane Work Group under the U.S. Climate Variability and Predictability Research Program (CLIVAR) using five global climate models (GCMs) with a total of 16 ensemble members forced by the observed sea surface temperature and spanning the 28-yr period from 1982 to 2009. The results show GISS and GFDL model ensemble means best simulate the interannual variability of TCs, and the multimodel ensemble mean (MME) follows. Also, the MME has the closest climate mean annual number of WNP TCs and the smallest root-mean-square error to the observation. Most GCMs can simulate the interannual variability of WNP TCs well, with stronger TC activities during two types of El Niño—namely, eastern Pacific (EP) and central Pacific (CP) El Niño—and weaker activity during La Niña. However, none of the models capture the differences in TC activity between EP and CP El Niño as are shown in observations. The inability of models to distinguish the differences in TC activities between the two types of El Niño events may be due to the bias of the models in response to the shift of tropical heating associated with CP El Niño

Actively implementing an evidence-based feeding guideline for critically ill patients (NEED): a multicenter, cluster-randomized, controlled trial

Background: Previous cluster-randomized controlled trials evaluating the impact of implementing evidence-based guidelines for nutrition therapy in critical illness do not consistently demonstrate patient benefits. A large-scale, sufficiently powered study is therefore warranted to ascertain the effects of guideline implementation on patient-centered outcomes. Methods: We conducted a multicenter, cluster-randomized, parallel-controlled trial in intensive care units (ICUs) across China. We developed an evidence-based feeding guideline. ICUs randomly allocated to the guideline group formed a local "intervention team", which actively implemented the guideline using standardized educational materials, a graphical feeding protocol, and live online education outreach meetings conducted by members of the study management committee. ICUs assigned to the control group remained unaware of the guideline content. All ICUs enrolled patients who were expected to stay in the ICU longer than seven days. The primary outcome was all-cause mortality within 28 days of enrollment. Results: Forty-eight ICUs were randomized to the guideline group and 49 to the control group. From March 2018 to July 2019, the guideline ICUs enrolled 1399 patients, and the control ICUs enrolled 1373 patients. Implementation of the guideline resulted in significantly earlier EN initiation (1.20 vs. 1.55 mean days to initiation of EN; difference − 0.40 [95% CI − 0.71 to − 0.09]; P = 0.01) and delayed PN initiation (1.29 vs. 0.80 mean days to start of PN; difference 1.06 [95% CI 0.44 to 1.67]; P = 0.001). There was no significant difference in 28-day mortality (14.2% vs. 15.2%; difference − 1.6% [95% CI − 4.3% to 1.2%]; P = 0.42) between groups. Conclusions: In this large-scale, multicenter trial, active implementation of an evidence-based feeding guideline reduced the time to commencement of EN and overall PN use but did not translate to a reduction in mortality from critical illness. Trial registration: ISRCTN, ISRCTN12233792. Registered November 20th, 2017

Actively implementing an evidence-based feeding guideline for critically ill patients (NEED): a multicenter, cluster-randomized, controlled trial.

BackgroundPrevious cluster-randomized controlled trials evaluating the impact of implementing evidence-based guidelines for nutrition therapy in critical illness do not consistently demonstrate patient benefits. A large-scale, sufficiently powered study is therefore warranted to ascertain the effects of guideline implementation on patient-centered outcomes.MethodsWe conducted a multicenter, cluster-randomized, parallel-controlled trial in intensive care units (ICUs) across China. We developed an evidence-based feeding guideline. ICUs randomly allocated to the guideline group formed a local "intervention team", which actively implemented the guideline using standardized educational materials, a graphical feeding protocol, and live online education outreach meetings conducted by members of the study management committee. ICUs assigned to the control group remained unaware of the guideline content. All ICUs enrolled patients who were expected to stay in the ICU longer than seven days. The primary outcome was all-cause mortality within 28 days of enrollment.ResultsForty-eight ICUs were randomized to the guideline group and 49 to the control group. From March 2018 to July 2019, the guideline ICUs enrolled 1399 patients, and the control ICUs enrolled 1373 patients. Implementation of the guideline resulted in significantly earlier EN initiation (1.20 vs. 1.55 mean days to initiation of EN; difference - 0.40 [95% CI - 0.71 to - 0.09]; P = 0.01) and delayed PN initiation (1.29 vs. 0.80 mean days to start of PN; difference 1.06 [95% CI 0.44 to 1.67]; P = 0.001). There was no significant difference in 28-day mortality (14.2% vs. 15.2%; difference - 1.6% [95% CI - 4.3% to 1.2%]; P = 0.42) between groups.ConclusionsIn this large-scale, multicenter trial, active implementation of an evidence-based feeding guideline reduced the time to commencement of EN and overall PN use but did not translate to a reduction in mortality from critical illness.Trial registrationISRCTN, ISRCTN12233792 . Registered November 20th, 2017

Actively implementing an evidence-based feeding guideline for critically ill patients (NEED): a multicenter, cluster-randomized, controlled trial (vol 26, 46, 2022)

BackgroundPrevious cluster-randomized controlled trials evaluating the impact of implementing evidence-based guidelines for nutrition therapy in critical illness do not consistently demonstrate patient benefits. A large-scale, sufficiently powered study is therefore warranted to ascertain the effects of guideline implementation on patient-centered outcomes.MethodsWe conducted a multicenter, cluster-randomized, parallel-controlled trial in intensive care units (ICUs) across China. We developed an evidence-based feeding guideline. ICUs randomly allocated to the guideline group formed a local "intervention team", which actively implemented the guideline using standardized educational materials, a graphical feeding protocol, and live online education outreach meetings conducted by members of the study management committee. ICUs assigned to the control group remained unaware of the guideline content. All ICUs enrolled patients who were expected to stay in the ICU longer than seven days. The primary outcome was all-cause mortality within 28 days of enrollment.ResultsForty-eight ICUs were randomized to the guideline group and 49 to the control group. From March 2018 to July 2019, the guideline ICUs enrolled 1399 patients, and the control ICUs enrolled 1373 patients. Implementation of the guideline resulted in significantly earlier EN initiation (1.20 vs. 1.55 mean days to initiation of EN; difference - 0.40 [95% CI - 0.71 to - 0.09]; P = 0.01) and delayed PN initiation (1.29 vs. 0.80 mean days to start of PN; difference 1.06 [95% CI 0.44 to 1.67]; P = 0.001). There was no significant difference in 28-day mortality (14.2% vs. 15.2%; difference - 1.6% [95% CI - 4.3% to 1.2%]; P = 0.42) between groups.ConclusionsIn this large-scale, multicenter trial, active implementation of an evidence-based feeding guideline reduced the time to commencement of EN and overall PN use but did not translate to a reduction in mortality from critical illness.Trial registrationISRCTN, ISRCTN12233792 . Registered November 20th, 2017

Evaluation and Impact Mechanism of High-Quality Development in China’s Coastal Provinces

With economic expansion having moderated to a “new normal” pace, the eastern coastal provinces have been given a new historical task of high-quality development and become a window and frontier of China’s high-quality development. By designing and optimizing an index system of high-quality development levels and using the entropy-TOPSIS method, the study selected 21 indicators, include economic vitality, residents’ living standards, innovation efficiency and green development, and took China’s eastern coastal provinces as an example to study the characteristics of spatial-temporal variations in the high-quality development level from 2010 to 2020. Then, the study used the obstacle degree model to explore the factors that are obstacles to high-quality development. The results show that the high-quality development of the eastern coastal provinces presents an “up-down-up” fluctuation, with an increase of 40.1%. In particular, the development level of the residents’ living standards dimension is higher, and the high-quality development level of each province shows different degrees of growth and gradually tends to balanced development, with the high-quality development of Shanghai, Jiangsu Province and Zhejiang Province in a dominant position. The spatial pattern of high-quality development in the study areas shows a spatial distribution pattern of “high in the east and low in the west, high in the north and low in the south”, in which the bipolar spatial effect of the innovation efficiency dimension is becoming more and more prominent, while the regional synergistic development effect of the residents’ living standard dimension is more obvious, and the high-quality development spatial pattern shows a “core-periphery” structure, and there is a path-dependent effect in time change, and agglomeration is produced by trickle-down effect in space. The obstacles to residents’ living standards are high, and the main obstacle factor has gradually changed from insufficient output in innovation to a reduction in the scale of foreign trade. In addition, the problems of unreasonable industrial structure and shortage of per capita public cultural resources still exist. In provinces with a high-quality development level and a relatively developed economy, the biggest obstacle factors are economic vitality and residents’ living standards. In provinces with a low level of high-quality development and a relatively backward economy, the biggest obstacle factors are green development and innovation efficiency, and there are both similarities and differences in the main obstacle factors among provinces

Regional Differences of Farmers’ Willingness to Grow Grain and Its Influencing Factors in Shandong Province under the Background of New-Type Urbanization

Taking Shandong Province as the research area, we explored the willingness of farmers to grow grain and the influencing factors. By constructing the evaluation system of their willingness with 6 levels and 15 indicators based on field investigation, and quantitatively analyzing the influence degree and impact assessment of factors through a logistic regression model, the regional differences in farmers’ willingness were summarized, and the influencing factors were recognized. This study indicates that there were obvious regional differences in farmers’ willingness, which were the highest in the western region, the second in the eastern region, and the lowest in the central region. Specifically, the willingness varies significantly among cities, among which Laiwu has the highest willingness (0.76), while Tai’an has the lowest (0.41). The level of urbanization in different regions and the main influencing factors are different, and the same factor has different degrees of influence on cities, leading to regional differences. In terms of urbanization level, the main influencing factors in areas with high urbanization levels are the proportion of grain income and grain expenditure. However, in areas with a low urbanization level, it is the farmers’ planting attitude. From the perspective of influence mode, different factors have positive and negative differences in the willingness. Additionally, farmers’ willingness is becoming more and more rational, and more consideration is given to economic benefits. Among the influencing factors, the land planting mode, the proportion of grain income, and the proportion of grain expenditure are the most important factors, and 82% (11) of the cities are affected by the above three factors. Finally, the corresponding incentive measures are proposed by the regional differences in the influencing factors in various cities