Relaying systems with reciprocity mismatch : impact analysis and calibration

Cooperative beamforming can provide significant performance improvement for relaying systems with the help of the channel state information (CSI). In time-division duplexing (TDD) mode, the estimated CSI will deteriorate due to the reciprocity mismatch. In this work, we examine the impact and the calibration of the reciprocity mismatch in relaying systems. To evaluate the impact of the reciprocity mismatch for all devices, the closed-form expression of the achievable rate is first derived. Then, we analyze the performance loss caused by the reciprocity mismatch at sources, relays, and destinations respectively to show that the mismatch at relays dominates the impact. To compensate the performance loss, a two-stage calibration scheme is proposed for relays. Specifically, relays perform the intra-calibration based on circuits independently. Further, the inter-calibration based on the discrete Fourier transform (DFT) codebook is operated to improve the calibration performance by cooperation transmission, which has never been considered in previous work. Finally, we derive the achievable rate after relays perform the proposed reciprocity calibration scheme and investigate the impact of estimation errors on the system performance. Simulation results are presented to verify the analytical results and to show the performance of the proposed calibration approach

Circ_0007385 promotes the proliferation and inhibits the apoptosis of non-small cell lung cancer cells via miR-337-3p-dependent regulation of LMO3

Background. This study intended to analyze the expression characteristic, functions and underlying mechanism of circular RNA_0007385 (circ_0007385) in non-small cell lung cancer (NSCLC). Methods and Results. RNA and protein expression was examined by real-time quantitative polymerase chain reaction (RT-qPCR) and Western blot assay. Cell counting kit 8 (CCK8) assay, colony formation assay, 5- Ethynyl-2’-deoxyuridine (EdU) assay and flow cytometry were applied to analyze cell proliferation ability. Flow cytometry was also conducted to assess cell apoptosis. Dual-luciferase reporter assay and RNA immunoprecipitation (RIP) assay were performed to verify the predicted target relationships. Xenograft tumor model was utilized to analyze the function of circ_0007385 in vivo, and immunohistochemistry (IHC) assay was used to analyze protein expression in xenograft tumor tissues. Circ_0007385 expression was notably enhanced in NSCLC tissues and cell lines. Circ_0007385 facilitated the proliferation but suppressed the apoptosis of NSCLC cells. Circ_0007385 acted as a sponge for microRNA-337-3p (miR-337-3p), and circ_0007385 overexpression-mediated effects were largely overturned by the overexpression of miR-337-3p in NSCLC cells. MiR-337-3p interacted with the 3’ untranslated region (3’UTR) of LIM-only protein 3 (LMO3). Circ_0007385 up-regulated LMO3 level by absorbing miR-337-3p in NSCLC cells. LMO3 overexpression largely reversed miR-337-3p overexpression-induced influences in NSCLC cells. Circ_0007385 knockdown significantly restrained the growth of xenograft tumors in vivo. Conclusion. Circ_0007385 promoted the proliferation ability and inhibited the apoptosis of NSCLC cells by binding to miR-337-3p to induce LMO3 expression

Hierarchical-Absolute Reciprocity Calibration for Millimeter-wave Hybrid Beamforming Systems

In time-division duplexing (TDD) millimeter-wave (mmWave) massive multiple-input multiple-output (MIMO) systems, the reciprocity mismatch severely degrades the performance of the hybrid beamforming (HBF). In this work, to mitigate the detrimental effect of the reciprocity mismatch, we investigate reciprocity calibration for the mmWave-HBF system with a fully-connected phase shifter network. To reduce the overhead and computational complexity of reciprocity calibration, we first decouple digital radio frequency (RF) chains and analog RF chains with beamforming design. Then, the entire calibration problem of the HBF system is equivalently decomposed into two subproblems corresponding to the digital-chain calibration and analog-chain calibration. To solve the calibration problems efficiently, a closed-form solution to the digital-chain calibration problem is derived, while an iterative-alternating optimization algorithm for the analog-chain calibration problem is proposed. To measure the performance of the proposed algorithm, we derive the Cram\'er-Rao lower bound on the errors in estimating mismatch coefficients. The results reveal that the estimation errors of mismatch coefficients of digital and analog chains are uncorrelated, and that the mismatch coefficients of receive digital chains can be estimated perfectly. Simulation results are presented to validate the analytical results and to show the performance of the proposed calibration approach

Transmission Electron Microscopic Morphological Study and Flow Cytometric Viability Assessment of Acinetobacter baumannii

Multidrug-resistant (MDR) Acinetobacter baumannii infections are difficult to treat owing to the extremely limited armamentarium. Expectations about antimicrobial peptides' use as new powerful antibacterial agents have been raised on the basis of their unique mechanism of action. Musca domestica cecropin (Mdc), a novel antimicrobial peptide from the larvae of Housefly (Musca domestica), has potently active against Gram-positive and Gram-negative bacteria standard strain. Here we evaluated the antibacterial activity of Mdc against clinical isolates of MDR-A. baumannii and elucidate the related antibacterial mechanisms. The minimal inhibitory concentration (MIC) of Mdc was 4 μg/mL. Bactericidal kinetics of Mdc revealed rapid killing of A. baumannii (30 min). Flow cytometry using viability stain demonstrated that Mdc causes A. baumannii membrane permeabilization in a concentration- and time-dependent process, which correlates with the bactericidal action. Moreover, transmission electron microscopic (TEM) examination showed that Mdc is capable of disrupting the membrane of bacterial cells, resulting in efflux of essential cytoplasmic components. Overall, Mdc could be a promising antibacterial agent for MDR-A. baumannii infections

Hierarchical-absolute reciprocity calibration for millimeter-wave hybrid beamforming systems

In time-division duplexing (TDD) millimeter-wave (mmWave) massive multiple-input multiple-output (MIMO) systems, the reciprocity mismatch severely degrades the performance of the hybrid beamforming (HBF). In this work, to mitigate the detrimental effect of the reciprocity mismatch, we investigate reciprocity calibration for the mmWave-HBF system with a fully-connected phase shifter network. To reduce the over-head and computational complexity of reciprocity calibration, we first decouple digital radio frequency (RF) chains and analog RF chains with beamforming design. Then, the entire calibration problem of the HBF system is equivalently decomposed into two subproblems corresponding to the digital-chain calibration and analog-chain calibration. To solve the calibration problems efficiently, a closed-form solution to the digital-chain calibration problem is derived, while an iterative-alternating optimization algorithm for the analog-chain calibration problem is proposed. To measure the performance of the proposed algorithm, we derive the Cramér-Rao lower bound on the errors in estimating mismatch coefficients. The results reveal that the estimation errors of mismatch coefficients of digital and analog chains are uncorrelated, and that the mismatch coefficients of receive digital chains can be estimated perfectly. Simulation results are presented to validate the analytical results and to show the performance of the proposed calibration approach

Control of sunroof buffeting noise by optimizing the flow field characteristics of a commercial vehicle

When a commercial vehicle is driving with the sunroof open, it is easy for the problem of sunroof buffeting noise to occur. This paper establishes the basis for the design of a commercial vehicle model that solves the problem of sunroof buffeting noise, which is based on computational fluid dynamics (CFD) numerical simulation technology. The large eddy simulation (LES) method was used to analyze the characteristics of the buffeting noise with different speed conditions while the sunroof was open. The simulation results showed that the small vortex generated in the cab forehead merges into a large vortex during the backward movement, and the turbulent vortex causes a resonance response in the cab cavity as the turbulent vortex moves above the sunroof and falls into the cab. Improving the flow field characteristics above the cab can reduce the sunroof buffeting noise. Focusing on the buffeting noise of commercial vehicles, it is proposed that the existing accessories, including sun visors and roof domes, are optimized to deal with the problem of sunroof buffeting noise. The sound pressure level of the sunroof buffeting noise was reduced by 6.7 dB after optimization. At the same time, the local pressure drag of the commercial vehicle was reduced, and the wind resistance coefficient was reduced by 1.55% compared to the original commercial vehicle. These results can be considered as relevant, with high potential applicability, within this field of researchThis work was supported by the National Natural Science Foundation of China (No. 52065013), the Guangxi Youth Science Fund Project (2018GXNSFBA281012), the Innovation-Driven Development Special Fund Project of Guangxi (Guike AA19182004), and the Liuzhou Scientific Research and Planning Development Project (2018AA20301)S

A New Soil Sampling Design in Coastal Saline Region Using EM38 and VQT Method

Spatial sampling design based on the variability and distribution of soil properties is an important issue with the progress in precision agriculture and soil ecology. Electromagnetic induction (type EM38) and variance quad-tree (VQT) method were both applied to optimize the sampling scheme of soil salinity in a coastal reclamation field in north Jiangsu Province, China. Apparent soil electrical conductivity (ECa) measured with EM38 was used as an ancillary variable and the spatial distribution of ECa was used as priori information. The process and result of VQT algorithm analysis was illustrated and the obtained sampling strategy was validated using observed soil salinity. Then the spatial precision and sampling efficiency were evaluated. The result indicated that the spatial distribution of soil salinity produced with the VQT scheme was quite similar to that produced with total sampling sites, while sampling quantity of the former was reduced to approximately 1/2 of the latter. The spatial precision of VQT scheme was considerably higher than that of traditional grid method with respect to the same sampling number, and fewer samples were required for VQT scheme to obtain the same precision level. A 17.3% increase in sampling efficiency was achieved by VQT over grid method at the precision level of 90%. The VQT method was proved to be more efficient and economical because it can sample intensively or sparsely according to variation status in local areas. The associated application of EM38 and VQT method provides efficient tools and theoretical basis for saving sampling cost and improving sampling efficiency in coastal saline region and enriching soil ecology

Impact and calibration of nonlinear reciprocity mismatch in massive MIMO systems

Time-division-duplexing massive multiple-input multiple-output (MIMO) systems estimate the channel state information (CSI) by leveraging the uplink-downlink channel reciprocity, which is no longer valid when the mismatch arises from the asymmetric uplink and downlink radio frequency (RF) chains. Existing works treat the reciprocity mismatch as constant for simplicity. However, the practical RF chain consists of nonlinear components, which leads to nonlinear reciprocity mismatch. In this work, we examine the impact and the calibration approach of the nonlinear reciprocity mismatch in massive MIMO systems. To evaluate the impact of the nonlinear mismatch, we first derive the closed-form expression of the ergodic achievable rate. Then, we analyze the performance loss caused by the nonlinear mismatch to show that the impact of the mismatch at the base station (BS) side is much larger than that at the user equipment side. Therefore, we propose a calibration method for the BS. During the calibration, polynomial function is applied to approximate the nonlinear mismatch factor, and over-the-air training is employed to estimate the polynomial coefficients. After that, the calibration coefficients are computed by maximizing the downlink achievable rate. Simulation results are presented to verify the analytical results and to show the performance of the proposed calibration approach

Revisit to the yield ratio of triton and 3^3He as an indicator of neutron-rich neck emission

The neutron rich neck zone created in heavy ion reaction is experimentally probed by the production of the $A=3$ isobars. The energy spectra and angular distributions of triton and $^3$He are measured with the CSHINE detector in $^{86}$Kr +$^{208}$Pb reactions at 25 MeV/u. While the energy spectrum of $^{3}$He is harder than that of triton, known as "$^{3}$He-puzzle", the yield ratio $R({\rm t/^3He})$ presents a robust rising trend with the polar angle in laboratory. Using the fission fragments to reconstruct the fission plane, the enhancement of out-plane $R({\rm t/^3He})$ is confirmed in comparison to the in-plane ratios. Transport model simulations reproduce qualitatively the experimental trends, but the quantitative agreement is not achieved. The results demonstrate that a neutron rich neck zone is formed in the reactions. Further studies are called for to understand the clustering and the isospin dynamics related to neck formation