Metabolic risk factors of cognitive impairment in young women with major psychiatric disorder

BackgroundCognitive performance improves clinical outcomes of patients with major psychiatric disorder (MPD), but is impaired by hyperglycemia. Psychotropic agents often induce metabolism syndrome (MetS). The identification of modifiable metabolic risk factors of cognitive impairment may enable targeted improvements of patient care.ObjectiveTo investigate the relationship between MetS and cognitive impairment in young women with MPD, and to explore risk factors.MethodsWe retrospectively studied women of 18–34 years of age receiving psychotropic medications for first-onset schizophrenia (SCH), bipolar disorder (BP), or major depressive disorder (MDD). Data were obtained at four time points: presentation but before psychotropic medication; 4–8 and 8–12 weeks of psychotropic therapy; and enrollment. MATRICS Consensus Cognitive Battery, (MCCB)—based Global Deficit Scores were used to assess cognitive impairment. Multiple logistic analysis was used to calculate risk factors. Multivariate models were used to investigate factors associated with cognitive impairment.ResultsWe evaluated 2,864 participants. Cognitive impairment was observed in 61.94% of study participants, and was most prevalent among patients with BP (69.38%). HbA1c within the 8–12 week-treatment interval was the most significant risk factor and highest in BP. Factors in SCH included pre-treatment waist circumference and elevated triglycerides during the 8–12 weeks treatment interval. Cumulative dosages of antipsychotics, antidepressants, and valproate were associated with cognitive impairment in all MPD subgroups, although lithium demonstrated a protect effect (all P < 0.001).ConclusionsCognitive impairment was associated with elevated HbA1c and cumulative medication dosages. Pre-treatment waist circumference and triglyceride level at 8–12 weeks were risk factors in SCH. Monitoring these indices may inform treatment revisions to improve clinical outcomes

Study of Wireless Authentication Center with Mixed Encryption in WSN

WSN (wireless sensor network) has been used in a wide range of applications nowadays. Sensor networks may often relay critical data; thus, security must be a high priority. However, due to their limited computational, energy, and storage resources, sensor nodes are vulnerable to attack. So how to protect sensor nodes from attacks without raising computational capability and energy consumption is a worthwhile issue. A WAC (wireless authentication center) with mixed encryption named "MEWAC" is proposed. MEWAC is based on MCU (Microcontroller Unit) and WiFi (Wireless Fidelity) module and uses RSA, AES (Advanced Encryption Standard), and SHA-1 (Secure Hash Algorithm 1) to provide high performance authentication and data encryption services for sensor nodes. The experimental results show that MEWAC has the advantages of low cost, low power consumption, good performance, and stability; moreover, the authentication protocol improves the security of WSN and reduces the overhead in node authentication

Study of Wireless Authentication Center with Mixed Encryption in WSN

WSN (wireless sensor network) has been used in a wide range of applications nowadays. Sensor networks may often relay critical data; thus, security must be a high priority. However, due to their limited computational, energy, and storage resources, sensor nodes are vulnerable to attack. So how to protect sensor nodes from attacks without raising computational capability and energy consumption is a worthwhile issue. A WAC (wireless authentication center) with mixed encryption named “MEWAC” is proposed. MEWAC is based on MCU (Microcontroller Unit) and WiFi (Wireless Fidelity) module and uses RSA, AES (Advanced Encryption Standard), and SHA-1 (Secure Hash Algorithm 1) to provide high performance authentication and data encryption services for sensor nodes. The experimental results show that MEWAC has the advantages of low cost, low power consumption, good performance, and stability; moreover, the authentication protocol improves the security of WSN and reduces the overhead in node authentication

Multifunctional Optoelectronic Synapses Based on Arrayed MoS2 Monolayers Emulating Human Association Memory

Abstract Optoelectronic synaptic devices integrating light‐perception and signal‐storage functions hold great potential in neuromorphic computing for visual information processing, as well as complex brain‐like learning, memorizing, and reasoning. Herein, the successful growth of MoS2 monolayer arrays assisted by gold nanorods guided precursor nucleation is demonstrated. Optical, spectral, and morphology characterizations of MoS2 prove that arrayed flakes are homogeneous monolayers, and they are further fabricated as optoelectronic devices showing featured photocurrent loops and stable optical responses. Typical synaptic behaviors of photo‐induced short‐term potentiation, long‐term potentiation, and paired pulse facilitation are recorded under different light stimulations of 450, 532, and 633 nm lasers at various excitation powers. A visual sensing system consisting of 5 × 6 pixels is constructed to simulate the light‐sensing image mapped by forgetting curves in real time. Moreover, the system presents the ability of utilizing associated images to restore vague and incomplete memories, which successfully mimics human intelligent behaviors of association memory and logical reasoning. The work emulates the brain‐like artificial intelligence using arrayed 2D semiconductors, which paves an avenue to achieve smart retina and complex brain‐like system

1α,25-Dihydroxyvitamin D3 Induces Neutrophil Apoptosis through the p38 MAPK Signaling Pathway in Chronic Obstructive Pulmonary Disease Patients.

Reduced neutrophil apoptosis plays an important role in the pathogenesis of acute exacerbation chronic obstructive pulmonary disease (AECOPD). The p38 mitogen-activated protein kinase (MAPK) signaling pathway is involved in neutrophil apoptosis. 1α,25-Dihydroxyvitamin D3 (1α,25VitD3) can induce tumor cell apoptosis. The aim of this study was to assess the effects of 1α,25VitD3 on peripheral blood neutrophil apoptosis in AECOPD and examine the role of the p38 MAPK signaling pathway.The study enrolled 36 AECOPD patients and 36 healthy volunteers. Venous blood samples were obtained from both groups. Serum 25-hydroxyvitamin D (25-(OH) D) levels in peripheral venous blood were assayed using liquid chromatography-tandem mass spectrometry (LC-MS/MS); the neutrophils were separated and cultured with SB203580 (a p38 inhibitor) and 1α,25VitD3. Neutrophil apoptosis was measured using flow cytometry, and phospho-p38 MAPK protein expression was detected by Western blot. Statistical analysis was performed using analysis of variance. Student's t-test and Pearson's correlation coefficient were used for the between-group differences and correlation analysis, respectively.The 25-(OH) D levels were lower in AECOPD patients than in healthy controls, and the peripheral blood neutrophil apoptosis results were similar. 1α,25VitD3 increased the apoptosis rate and the level of phospho-p38 MAPK in peripheral blood neutrophils of AECOPD patients. SB203580 partly inhibited 1α,25VitD3-induced peripheral blood neutrophil apoptosis and phospho-p38 MAPK overexpression. The 25-(OH) D levels were positively correlated with increased peripheral blood neutrophil apoptosis and phospho-p38 MAPK levels. In addition, expression of the phospho-p38 MAPK protein was also positively correlated with peripheral blood neutrophil apoptosis.Our results suggest that 1α,25VitD3 induces peripheral blood neutrophil apoptosis through the p38 MAPK signaling pathway in AECOPD patients

Baseline characteristics of the study sample, presented as the mean ± s.d. for continuous variable and as the percentage for categorical variables.

<p>^#smokers/ex-smokers/nonsmokers.</p><p>*FEV₁: Forced expiratory volume in 1 s.</p><p>†PaO₂: arterial oxygen tension.</p><p>^§LTDOT: Long-term domiciliary oxygen therapy.</p><p>^##Exacerbations requiring either hospitalization or treatment with oral antibiotics or oral steroids.</p><p>**Associations were tested with t-test and Chi-square.</p><p>Baseline characteristics of the study sample, presented as the mean ± s.d. for continuous variable and as the percentage for categorical variables.</p

correlation analysis.

<p>The serum 25-(OH) D level correlates with the neutrophil apoptosis in the AECOPD patients(a). The serum 25-(OH) D level correlates with the phospho-p38 MAPK in the AECOPD patients(b). The correlation between the neutrophil apoptosis and phospho-p38 MAPK/p38 MAPK in AECOPD patients(c). The <i>r</i> and <i>p</i> values were assessed using Pearson's correlation analysis.</p