1 research outputs found
Developing Bis(imino)acenaphthene-Supported <i>N</i>‑Heterocyclic Carbene Palladium Precatalysts for Direct Arylation of Azoles
On
the basis of the strategy of developing highly efficient protocol
for Pd-catalyzed cross-coupling reactions, a series of bulky bisÂ(imino)Âacenaphthene
(BIAN)-supported Pd-PEPPSI complexes were synthesized, characterized,
and applied in direct arylation of azoles. The effect of backbone
and <i>N</i>-moieties on NHCs was evaluated, and the reaction
conditions were optimized.
It was found that the bulky Pd-PEPPSI complexes could be successfully
employed in cross-coupling of (hetero)Âaryl bromides with azoles at
a low palladium loading of 0.5–0.05 mol % under aerobic conditions,
demonstrating the ease of manipulation without glovebox and handling
of solvents