Effectiveness of Shared Mental Models on the Success of Multi-Institutional Collaboration to Deliver Online Learning Programs

This poster focuses on employing the construct of shared mental models (SMMs) to measure the effectiveness of collaboration in two projects featuring multi-institutional effort to deliver emergent LIS learning programs. Specifically, various teams involved in developing RDMLA (Research Data Management Librarian Academy) and IPI (Interprofessional Informationist) programs were examined. RDMLA is an online training program for practicing librarians and other professionals who engage in data-intensive work. The IPI program is an IMLS-funded post Master’s certificate program which aims to provide education and training to bridge the gap between traditional and emergent skills in health sciences librarians. Based on research work on SMMs and teamwork (e.g. Cannon-Bowers, Salas, & Converse, 1993; Marks, Mathieu & Zaccaro, 2001), a framework (Fig. 1) was developed to measure multiple types of mental models. Components of the SMMs will be extracted to identify the association between the degree of sharedness and the successful delivery of learning programs. Findings will benefit LIS educators in their effort of developing community-based collaborative learning programs

Differential expression of proteins regulating cell cycle progression in growth vs. differentiation

AbstractThe level of various G1 cyclins and cyclin-dependent kinases (cdks) present in the nuclei of synchronized ML-1 human myeloblastic leukemia cells was determined as a function of time after initiation of cell growth with insulin-like growth factor-1 (IGF-1) and transferrin (Tf), and following induction of differentiation with transforming growth factor-β1 (TGF-β1). Cyclin E and cdk2 were expressed at relatively high levels in the nuclei of proliferation-stimulated cells, whereas cyclin D1 and cdk5 were expressed at comparably high levels in the nuclei of differentiation-induced cells. In the nuclear extracts from proliferation-stimulated cells, cyclin E complexed specifically with cdk2, whereas in nuclear extracts from differentiation-induced cells, cyclin D1 bound specifically to cdk5. Increased cyclin E/cdk2 expression was accompanied by increased DNA synthesis, whereas increased cyclin D1/cdk5 levels correlated with decreased DNA synthesis. In both growth- and differentiation-induced cells, cyclin D2 expression preceded the expression of cyclin D3, and a significantly larger amount of these cyclins was present in differentiation- as compared to proliferation-induced cells. In contrast, cdk4 and cdk6 were present at similar levels in the nuclear extracts from both growth- and differentiation-induced cells. These data show that, in ML-1 cells, the proliferation-associated progression from G1 to S, as well as the differentiation-associated transit from G1 to maturation is accompanied by the expression of specific cyclin/cdk pairs, comprising cdk2/cyclin E in growth and cdk5/cyclin D1 in differentiation