4 research outputs found
Nucleobase Containing Synthetic Polymers: Advancing Biomimicry via Controlled Synthesis and Self-Assembly
The hydrogen-bonding recognition interactions of nucleobases
are
a fundamental property of nucleic acid chemistry and associated transcription,
translation, and replication functions. Nucleobase interactions are
central in protein biosynthesis, yielding sequence- and stereospecific
macromolecules capable of assembly into precisely defined, complex
shapes and morphologies that make up the machinery of life. As the
understanding of nucleobases and their significance developed in the
past century, chemists have inevitably sought to extend their function
from a biological setting onto wholly synthetic platforms. Recent
advances point to a burgeoning area of study which may soon bear fruit
in some of the holy grails of polymer synthesis, namely sequence (and
stereo) control, single chain manipulation, and controlled polymer
folding. This Perspective seeks to summarize recent developments in
the area of nucleobase containing polymers (including nucleobase mimics),
with particular emphasis on controlled polymerization, self-assembly,
and templating polymerization
Synthesis and Aggregation of Double Hydrophilic Diblock Glycopolymers via Aqueous SET-LRP
A chemically unprotected mannose-containing
acrylate (ManA) monomer
was synthesized and polymerized by Cu(0)-mediated radical polymerization
in water (SET-LRP). One-pot block copolymerization was achieved upon
addition of a solution of <i>N</i>-isopropylacrylamide (NIPAm)
or diethylene glycol ethyl ether acrylate (DEGEEA) forming thermoresponsive
double hydrophilic diblock glycopolymers which revealed self-assembly
properties in aqueous solution forming well-defined, sugar-decorated
nanoparticles
Aqueous Copper-Mediated Living Polymerization: Exploiting Rapid Disproportionation of CuBr with Me<sub>6</sub>TREN
A new approach to
perform single-electron transfer living radical
polymerization (SET-LRP) in water is described. The key step in this
process is to allow full disproportionation of CuBr/Me<sub>6</sub>TREN (TREN = tris(dimethylamino)ethyl amine to Cu(0) powder and CuBr<sub>2</sub> in water prior to addition of both monomer and initiator.
This provides an extremely powerful tool for the synthesis of functional
water-soluble polymers with controlled chain length and narrow molecular
weight distributions (polydispersity index approximately 1.10), including
poly(<i>N</i>-isopropylacrylamide), <i>N</i>,<i>N</i>-dimethylacrylamide, poly(ethylene glycol) acrylate, 2-hydroxyethyl
acrylate (HEA), and an acrylamido glyco monomer. The polymerizations
are performed at or below ambient temperature with quantitative conversions
attained in minutes. Polymers have high chain end fidelity capable
of undergoing chain extensions to full conversion or multiblock copolymerization
via iterative monomer addition after full conversion. Activator generated
by electron transfer atom transfer radical polymerization of <i>N</i>-isopropylacrylamide in water was also conducted as a comparison
with the SET-LRP system. This shows that the addition sequence of l-ascorbic acid is crucial in determining the onset of disproportionation,
or otherwise. Finally, this robust technique was applied to polymerizations
under biologically relevant conditions (PBS buffer) and a complex
ethanol/water mixture (tequila)
A medieval farming glossary of Latin and English words Taken mainly from Essex records
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