Fitted parameter values obtained using Peak Expiratory Flow Rate (PEFR) and Adverse event rate (AE rate) respectively as target outcomes.

<p>Fitted parameter values obtained using Peak Expiratory Flow Rate (PEFR) and Adverse event rate (AE rate) respectively as target outcomes.</p

Summary statistics for asthma cohort.

<p>Summary statistics for asthma cohort.</p

The effects of parameters <i>θ</i> and <i>β</i> on the threshold function.

<p>For large values of <i>β</i> the function becomes step-like, while for small values it is smoother, and approximately linear. Changes in <i>θ</i> shift the function to the right or left.</p

Summary statistics for INCA-COPD study.

<p>Summary statistics for INCA-COPD study.</p

Simulated absorbed ICS concentrations for two patients using Seretide inhalers, with target threshold concentration, <i>θ</i>.

<p>In both cases the patient has received 4 doses over the period shown. The patient in (a) is more successful in maintaining above-target concentration, while in (b) the concentration drops below target on several occasions.</p

Values of parameter <i>δ</i> corresponding to particular technique errors.

<p>Results obtained from calibration tests of the INCA device [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0195663#pone.0195663.ref044" target="_blank">44</a>].</p