187 research outputs found
First report of simultaneous transcatheter aortic valve replacement, endovascular aortic aneurysm repair, and permanent pacemaker implantation after multi-vessel coronary stenting and left atrial appendage occlusion
Optical coherence tomography follow-up after bioresorbable in metallic and metallic in bioresorbable stenting: tackling in-stent restenosis in the era of bioresorbable vascular scaffolds
First report of simultaneous transcatheter aortic valve replacement, endovascular aortic aneurysm repair, and permanent pacemaker implantation after multi-vessel coronary stenting and left atrial appendage occlusion
Power-law correlations and orientational glass in random-field Heisenberg models
Monte Carlo simulations have been used to study a discretized Heisenberg
ferromagnet (FM) in a random field on simple cubic lattices. The spin variable
on each site is chosen from the twelve [110] directions. The random field has
infinite strength and a random direction on a fraction x of the sites of the
lattice, and is zero on the remaining sites. For x = 0 there are two phase
transitions. At low temperatures there is a [110] FM phase, and at intermediate
temperature there is a [111] FM phase. For x > 0 there is an intermediate phase
between the paramagnet and the ferromagnet, which is characterized by a
|k|^(-3) decay of two-spin correlations, but no true FM order. The [111] FM
phase becomes unstable at a small value of x. At x = 1/8 the [110] FM phase has
disappeared, but the power-law correlated phase survives.Comment: 8 pages, 12 Postscript figure
Sandpiles with height restrictions
We study stochastic sandpile models with a height restriction in one and two
dimensions. A site can topple if it has a height of two, as in Manna's model,
but, in contrast to previously studied sandpiles, here the height (or number of
particles per site), cannot exceed two. This yields a considerable
simplification over the unrestricted case, in which the number of states per
site is unbounded. Two toppling rules are considered: in one, the particles are
redistributed independently, while the other involves some cooperativity. We
study the fixed-energy system (no input or loss of particles) using cluster
approximations and extensive simulations, and find that it exhibits a
continuous phase transition to an absorbing state at a critical value zeta_c of
the particle density. The critical exponents agree with those of the
unrestricted Manna sandpile.Comment: 10 pages, 14 figure
Sex Differences in Mortality After Transcatheter Aortic Valve Replacement for Severe Aortic Stenosis
ObjectivesThe aim of this study was to examine sex differences in outcome after transcatheter aortic valve replacement (TAVR) with real-world data from 2 large centers in Canada.BackgroundTranscatheter aortic valve replacement is an effective alternative to surgical valve replacement in symptomatic patients with severe aortic stenosis, but the impact of sex on outcomes remains unclear. The PARTNER (Placement of Aortic Transcatheter Valves) 1A trial demonstrated greater benefit of TAVR over surgery in women, but whether this was due to the poorer surgical outcome of women or better TAVR outcome, compared with men, is unknown.MethodsConsecutive patients (n = 641) undergoing TAVR in Vancouver and Quebec City, Canada, were evaluated. Differences in all-cause mortality were examined with Kaplan-Meier estimates, adjusted logistic regression, and proportional hazards models.ResultsWomen comprised 51.3% of the cohort. Balloon-expandable valves were used in 97% of cases, with transapical approach in 51.7 % women and 38.1% men. Women had more major vascular complications (12.4% vs. 5.4%, p = 0.003) and borderline significantly more major/life-threatening bleeds (21.6% vs. 15.8%, p = 0.08). At baseline, women had higher aortic gradients and worse renal function but better ejection fractions. Men had more comorbidities: prior myocardial infarction, prior revascularization, and chronic obstructive pulmonary disease. The adjusted odds ratio for 30-day all-cause mortality favored women, 0.39 (95% confidence interval: 0.19 to 0.80; p = 0.01), and this benefit persisted for 2 years, hazard ratio 0.60 (95% confidence interval: 0.41 to 0.88; p = 0.008).ConclusionsFemale sex is associated with better short- and long-term survival after TAVR. Added to the PARTNER 1A findings, these results suggest TAVR might be the preferred treatment option for elderly women with symptomatic severe aortic stenosis
Pair contact process with a particle source
We study the phase diagram and critical behavior of the one-dimensional pair
contact process (PCP) with a particle source using cluster approximations and
extensive simulations. The source creates isolated particles only, not pairs,
and so couples not to the order parameter (the pair density) but to a
non-ordering field, whose state influences the evolution of the order
parameter. While the critical point p_c shows a singular dependence on the
source intensity, the critical exponents appear to be unaffected by the
presence of the source, except possibly for a small change in beta. In the
course of our study we obtain high-precision values for the critical exponents
of the standard PCP, confirming directed-percolation-like scaling.Comment: 15 pages, 9 figure
Impact of postdilatation on performance of bioresorbable vascular scaffolds in patients with acute coronary syndrome compared with everolimus-eluting stents: A propensity score-matched analysis from a multicenter “real-world” registry
Background: Safety and efficacy of bioresorbable vascular scaffolds (BRS) and the role of postdilatation on outcome in acute coronary syndrome (ACS) patients compared with those of everolimus-eluting stents (EES) remain unknown. The aim of the study is to compare the safety and efficacy of BRS with EES in ACS and to investigate the role of BRS postdilatation.
Methods: Consecutive ACS patients undergoing BRS implantation in 8 centers were comÂpared with those with EES before and after propensity score matching. Major adverse cardiac event (MACE), myocardial infarction, and target lesion revascularization (TLR) were the primary endpoint. Sensitivity analysis was performed according to postdilatation after BRS implantation. We enrolled 303 BRS and 748 EES patients; 215 from each group were comÂpared after matching, and 117 (55.2%) BRS patients were treated with postdilatation.
Results: After a median follow-up of 24.0 months, MACE rates were higher in BRS patients than in EES patients (9.3% vs. 4.7%, p < 0.001), mainly driven by TLR (6.1% vs. 1.9%, p < 0.001). Stent thrombosis increased in the BRS group (2.8% vs. 0.9%, p = 0.01). HowÂever, after sensitivity analysis, MACE rates in BRS patients with postdilatation were signifiÂcantly lower than in those without, comparable to EES patients (6.0% vs. 12.6% vs. 4.7%, p < 0.001). The same trend was observed for TLR (3.4% vs. 8.4% vs. 1.9%, p < 0.001). Stent thrombosis rates were higher in both the BRS groups than in EES patients (2.6% vs. 3.2% vs. 0.9%, p = 0.045).
Conclusions: Postdilatation appears effective when using BRS in ACS patients. MACE rates are comparable to those of EES, although scaffold thrombosis is not negligible. Randomized prospective studies are required for further investigation
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