Field Evaluation of Herbicides on Vegetables and Small Fruits 2004

Herbicide evaluation studies on vegetables and small fruits were conducted in 2004 at the Arkansas Agricultural Experiment Station at Fayetteville, AR, in an effort to evaluate new herbicides, herbicide mixtures, and their application timings for weed control efficacy and crop tolerance. Results of these studies, in part, provide useful information to producers, fellow researchers, the Crop Protection Industry, and the IR-4 Minor Crop Pest Management Program in the development of potential new herbicide uses in vegetable, and fruit

Field Evaluation of Herbicides on Rice 2005

Field studies to evaluate herbicides in rice weed management systems were conducted in 2005 at the Rice Research and Extension Center near Stuttgart, Arkansas. New herbicides, herbicide mixtures, and application timings were evaluated for weed control efficacy and rice tolerance. Results of these studies, in part, provide useful information to producers, fellow researchers, and the crop protection industry for the most effective, economical herbicide programs for successful rice production in Arkansas

Field Evaluation of Herbicides on Rice 2004

Herbicide evaluation studies on rice were conducted in 2004 at the Rice Research and Extension Center near Stuttgart, AR, in an effort to evaluate new herbicides, herbicide mixtures, and their application timings for weed control and crop tolerance. Results of these studies, in part, provide useful information to producers, fellow researchers, and the Crop Protection Industry for the potential use of new herbicide programs for successful rice production in Arkansas

Distance of Interference of Red Rice (Orya sativa) in Rice (O. sativa)

Three rice cultivars were grown to determine the distance at which red rice affects growth and grain yield. Red rice reduced grain yield of Lemont when rice plants grew within 71 and 53 cm of red rice in 1986 and 1988, respectively. Grain yield of Newbonnet was reduced when grown within 53 cm of red rice in both years. Grain yield of Tebonnet was reduced when grown within 53 and 36 cm of red rice in 1986 and 1988, respectively. Grain yield reduction in influenced areas averaged 35, 26 and 21% for Lemont, Newbonnet, and Tebonnet, respectively. As the distance increased at 10-cm increments from the red rice row, Lemont, Newbonnet, and Teboment grain yields increased 49 to 85, 32 to 40, and 24 to 33 g/m2, respectively. Rice straw dry weight was reduced when Lemont and Tebonnet were grown within71 and 36 cm of red rice in 1986 and 1988, respectively. Straw dry weight of Newbonnet was reduced when grown within 36 cm of red rice in both years. As the distance increased at 10-cm increments from the red rice row, Lemont, Newbonnet and Tebonnet straw biomass increased 22 to 46, 10 to 18, and 12 to 20 g/m2,respectively. Rice panicles/ m2 were reduced when Lemont, Newbonnet, and Tebonnet were grown within 36, 18, and 18 cm of red rice, respectively. Rice grains/panicle were reduced when rice was grown within 71, 71, and 36 cm of red rice for Lemont, Newbonnet, and Tebonnet, respectively

Field Evaluation of Herbicides on Rice 2003

Herbicide evaluation studies on rice were conducted in 2003 at the Rice Research and Extension Center near Stuttgart, Ark., in an effort to evaluate new herbicides, herbicide mixtures, and their application timings for weed control efficacy and crop tolerance. Results of these studies, in part, provide useful information to producers, fellow researchers, and the crop protection industry for the potential use of new herbicide programs for successful rice production in Arkansas

Field Evaluation of Herbicides on Vegetables, Small Fruit, and Ornamental Crops 2003

Herbicide evaluation studies on vegetables, small fruit, and ornamental crops were conducted in 2003 at the Arkansas Agricultural Experiment Station in Fayetteville, Ark., and the Vegetable Substation near Kibler, Ark., in an effort to evaluate new herbicides, herbicide mixtures, and their application timings for weed control efficacy and crop tolerance. Results of these studies, in part, provide useful information to producers, fellow researchers, the Crop Protection Industry, and the IR-4 Minor Crop Pest Management Program in the development of potential new herbicide uses in vegetable, fruit, and ornamental production

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016) : part two

Background The immunological escape of tumors represents one of the main ob- stacles to the treatment of malignancies. The blockade of PD-1 or CTLA-4 receptors represented a milestone in the history of immunotherapy. However, immune checkpoint inhibitors seem to be effective in specific cohorts of patients. It has been proposed that their efficacy relies on the presence of an immunological response. Thus, we hypothesized that disruption of the PD-L1/PD-1 axis would synergize with our oncolytic vaccine platform PeptiCRAd. Methods We used murine B16OVA in vivo tumor models and flow cytometry analysis to investigate the immunological background. Results First, we found that high-burden B16OVA tumors were refractory to combination immunotherapy. However, with a more aggressive schedule, tumors with a lower burden were more susceptible to the combination of PeptiCRAd and PD-L1 blockade. The therapy signifi- cantly increased the median survival of mice (Fig. 7). Interestingly, the reduced growth of contralaterally injected B16F10 cells sug- gested the presence of a long lasting immunological memory also against non-targeted antigens. Concerning the functional state of tumor infiltrating lymphocytes (TILs), we found that all the immune therapies would enhance the percentage of activated (PD-1pos TIM- 3neg) T lymphocytes and reduce the amount of exhausted (PD-1pos TIM-3pos) cells compared to placebo. As expected, we found that PeptiCRAd monotherapy could increase the number of antigen spe- cific CD8+ T cells compared to other treatments. However, only the combination with PD-L1 blockade could significantly increase the ra- tio between activated and exhausted pentamer positive cells (p= 0.0058), suggesting that by disrupting the PD-1/PD-L1 axis we could decrease the amount of dysfunctional antigen specific T cells. We ob- served that the anatomical location deeply influenced the state of CD4+ and CD8+ T lymphocytes. In fact, TIM-3 expression was in- creased by 2 fold on TILs compared to splenic and lymphoid T cells. In the CD8+ compartment, the expression of PD-1 on the surface seemed to be restricted to the tumor micro-environment, while CD4 + T cells had a high expression of PD-1 also in lymphoid organs. Interestingly, we found that the levels of PD-1 were significantly higher on CD8+ T cells than on CD4+ T cells into the tumor micro- environment (p < 0.0001). Conclusions In conclusion, we demonstrated that the efficacy of immune check- point inhibitors might be strongly enhanced by their combination with cancer vaccines. PeptiCRAd was able to increase the number of antigen-specific T cells and PD-L1 blockade prevented their exhaus- tion, resulting in long-lasting immunological memory and increased median survival