Additional file 1 of Evaluating the impact of glucokinase activation on risk of cardiovascular disease: a Mendelian randomisation analysis

Additional file 1. Table S1. Information of included summary-level statistics. Table S2. Associations of instrumental variables for GK activation in main analyses with exposure and outcomes. Table S3. Colocalization analysis of genetically proxied GK activation and outcomes. Table S4. Associations of instrumental variables for GK activation in sensitivity analyses with exposure and outcomes. Table S5. Instrumental variables for GK activation in East Asian population and their associations with HbA1c. Table S6. Associations of genetically proxied GK activation with risks of cardiovascular outcomes in East Asian population. Table S7. Instrumental variables for non-targeted HbA1c lowering and their associations with HbA1c. Table S8. Associations of genetically predicted lower HbA1c with outcomes after removing GCK variants. Figure S1. Conceptual framework of study design. Supplementary Method. Brief summary of outcome definition