Acute effects of inspiratory pressure threshold loading upon airway resistance in people with asthma

This is the post-print version of the final paper published in Respiratory Physiology & Neurobiology. The published article is available from the link below. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. Copyright @ 2009 Elsevier B.V.Large inspiratory pressures may impart stretch to airway smooth muscle and modify the response to deep inspiration (DI) in asthmatics. Respiratory system resistance (Rrs) was assessed in response to 5 inspiratory manoeuvres using the forced oscillation technique: (a) single unloaded DI; (b) single DI at 25 cmH2O; (c) single DI at 50% maximum inspiratory mouth pressure [MIP]; (d) 30 DIs at 50% MIP; and (e) 30 DIs at 50% MIP with maintenance of normocapnia. Rrs increased after the unloaded DI and the DI at 25 cmH2O but not after a DI at 50% MIP (3.6 ± 1.6 hPa L s−1 vs. 3.6 ± 1.5 hPa L s−1; p = 0.95), 30 DIs at 50% MIP (3.9 ± 1.5 hPa L s−1 vs. 4.2 ± 2.0 hPa L s−1; p = 0.16) or 30 DIs at 50% MIP under normocapnic conditions (3.9 ± 1.5 hPa L s−1 vs. 3.9 ± 1.5 hPa L s−1; p = 0.55). Increases in Rrs in response to DI were attenuated after single and multiple loaded breaths at 50% MIP

X-ray Observations of Distant Optically Selected Cluster

We have measured fluxes or flux limits for 31 of the 79 cluster candidates in the Palomar Distant Cluster Survey (PDCS) using archival ROSAT/PSPC pointed observations. Our X-ray survey reaches a flux limit of $\simeq 3 \times 10^{-14}$ erg s$^{-1}$ cm$^{-2}$ (0.4 - 2.0 keV), which corresponds to luminosities of $L_x\simeq 5 \times 10^{43}$ erg s$^{-1}$ ($H_o$ = 50 km s$^{-1}$ Mpc$^{-1}$, $q_o$ = ${1/2}$), if we assume the PDCS estimated redshifts. Of the 31 cluster candidates, we detect six at a signal-to-noise greater than three. We estimate that $2.9^{+3.3}_{-1.4}$ (90% confidence limits) of these six detections are a result of X-ray emission from objects unrelated to the PDCS cluster candidates. The net surface density of X-ray emitting cluster candidates in our survey, $1.71^{+0.91}_{-2.19}$ clusters deg$^{-2}$, agrees with that of other, X-ray selected, surveys. It is possible, given the large error on our contamination rate, that we have not detected X-ray emission from any of our observed PDCS cluster candidates. We find no statistically significant difference between the X-ray luminosities of PDCS cluster candidates and those of Abell clusters of similar optical richness. This suggests that the PDCS contains objects at high redshift similar to the low redshift clusters in the Abell catalogs. We show that the PDCS cluster candidates are not bright X-ray sources, the average luminosity of the six detected candidates is only $\bar{L_x}=0.9\times10^{44}$ erg s$^{-1}$ (0.4-2.0 keV). This finding is in agreement with previous X-ray studies of high redshift, optically selected, rich clusters of galaxies.Comment: 19 pages, LaTeX with AAS Preprint Macros (v. 4), 3 embedded postscript figures, 3 Seperate Tables using aj_pt4.sty, Accepted by the Astronomical Journal for November 199

Testing the lognormality of the galaxy and weak lensing convergence distributions from Dark Energy Survey maps

It is well known that the probability distribution function (PDF) of galaxy density contrast is approximately lognormal; whether the PDF of mass fluctuations derived from weak lensing convergence (kappaWL) is lognormal is less well established. We derive PDFs of the galaxy and projected matter density distributions via the Counts in Cells (CiC) method. We use maps of galaxies and weak lensing convergence produced from the Dark Energy Survey (DES) Science Verification data over 139 deg2. We test whether the underlying density contrast is well described by a lognormal distribution for the galaxies, the convergence and their joint PDF. We confirm that the galaxy density contrast distribution is well modeled by a lognormal PDF convolved with Poisson noise at angular scales from 10'- 40'(corresponding to physical scales of 3-10 Mpc). We note that as kappaWL is a weighted sum of the mass fluctuations along the line of sight, its PDF is expected to be only approximately lognormal. We find that the kappaWL distribution is well modeled by a lognormal PDF convolved with Gaussian shape noise at scales between 10'and 20', with a best-fit chi2/DOF of 1.11 compared to 1.84 for a Gaussian model, corresponding to p-values 0.35 and 0.07 respectively, at a scale of 10'. Above 20'a simple Gaussian model is sufficient. The joint PDF is also reasonably fitted by a bivariate lognormal. As a consistency check we compare the variances derived from the lognormal modelling with those directly measured via CiC. Our methods are validated against maps from the MICE Grand Challenge N-body simulation

Cosmology constraints from shear peak statistics in Dark Energy Survey Science Verification data

Shear peak statistics has gained a lot of attention recently as a practical alternative to the two-point statistics for constraining cosmological parameters. We perform a shear peak statistics analysis of the Dark Energy Survey (DES) Science Verification (SV) data, using weak gravitational lensing measurements from a 139 deg² field. We measure the abundance of peaks identified in aperture mass maps, as a function of their signal-to-noise ratio, in the signal-to-noise range 04 would require significant corrections, which is why we do not include them in our analysis. We compare our results to the cosmological constraints from the two-point analysis on the SV field and find them to be in good agreement in both the central value and its uncertainty. We discuss prospects for future peak statistics analysis with upcoming DES data

A Turn-over in the Galaxy Luminosity Function of the Coma Cluster Core?

Our previous study of the faint end (R$\leq$21.5) of the galaxy luminosity function (GLF) was based on spectroscopic data in a small region near the Coma cluster center. In this previous study Adami et al. (1998) suggested, with moderate statistical significance, that the number of galaxies actually belonging to the cluster was much smaller than expected. This led us to increase our spectroscopic sample. Here, we have improved the statistical significance of the results of the Coma GLF faint end study (R$\leq$22.5) by using a sample of 85 redshifts. This includes both new spectroscopic data and a literature compilation. The relatively small number of faint galaxies belonging to Coma that was suggested by Adami et al. (1998) and Secker et al. (1998) has been confirmed with these new observations. We also confirm that the color-magnitude relation is not well suited for finding the galaxies inside the Coma cluster core, close to the center at magnitudes fainter than R$\sim$19. We show that there is an enhancement in the Coma line of sight of field galaxies compared to classical field counts. This can be explained by the contribution of groups and of a distant $z\sim 0.5$ cluster along the line of sight. The result is that the Coma GLF appears to turn-over or at least to become flat for the faint galaxies. We suggest that this is due to environmental effects.Comment: 8 pages, 6 postscript figures, accepted in A&A, new table 1, updated figure