15 research outputs found
Comparison of EPR occupational lifetime external dose assessments for Mayak nuclear workers and film badge dose data
The 4th International Comparison of EPR dosimetry with Tooth Enamel: Part 1, Report on the results
Analysis of EPR and FISH studies of radiation doses in persons who lived in the upper reaches of the Techa River
Effect of summer daylight exposure and genetic background on growth in growth hormone-deficient children.
The response to growth hormone in humans is dependent on phenotypic, genetic and environmental factors. The present study in children with growth hormone deficiency (GHD) collected worldwide characterised gene–environment interactions on growth response to recombinant human growth hormone (r-hGH). Growth responses in children are linked to latitude, and we found that a correlate of latitude, summer daylight exposure (SDE), was a key environmental factor related to growth response to r-hGH. In turn growth response was determined by an interaction between both SDE and genes known to affect growth response to r-hGH. In addition, analysis of associated networks of gene expression implicated a role for circadian clock pathways and specifically the developmental transcription factor NANOG. This work provides the first observation of gene–environment interactions in children treated with r-hGH