Clinical case of favourable outcome at a patient with eosinophilic granulomatosis with polyangiitis complicated by severe heart disease

The aim of the article is to present a clinical case of rapid generalization of eosinophilic granulomatosis with polyangiitis. The course of disease with multiple organ lesions and the heart being affected the most is described. Remission is achieved by combined therapy with corticosteroids and cyclophosphamide.</p

Self-induced and induced transparencies of two-dimensional and three- dimensional superlattices

The phenomenon of transparency in two-dimensional and three-dimensional superlattices is analyzed on the basis of the Boltzmann equation with a collision term encompassing three distinct scattering mechanisms (elastic, inelastic and electron-electron) in terms of three corresponding distinct relaxation times. On this basis, we show that electron heating in the plane perpendicular to the current direction drastically changes the conditions for the occurrence of self-induced transparency in the superlattice. In particular, it leads to an additional modulation of the current amplitudes excited by an applied biharmonic electric field with harmonic components polarized in orthogonal directions. Furthermore, we show that self-induced transparency and dynamic localization are different phenomena with different physical origins, displaced in time from each other, and, in general, they arise at different electric fields.Comment: to appear in Physical Review

The results of the scientific and practical conference 'The topical problems of forensic medicine and medical law', Moscow, 23.12. 2016 [O rabote nauchno-prakticheskoĭ konferentsii 'Aktual'nye voprosy sudebnoĭ meditsiny i meditsinskogo prava'. Moskva, 23.12.2016]

[No abstract available

Assessment of lung morphological changes in acute intoxications with clozapine, ethanol and their combination

Objective: to detect lung morphological changes in acute intoxications with clozapine, ethanol, and their combination 3 and 24 hours after poisoning. Materials and methods. Experiments were carried out in outbred male rats weighing 270–300 g. Clozapine was given in a dose of 250 mg per kg animal body weight under chloralose anesthesia. Following 3 and 24 hours, the animals were withdrawn from the experiment by decapitation. Lung histological sections from 6 rats that had received oral clozapine 250 mg/kg, 6 rats that had oral ethanol 8.6 ml/kg, and 6 rats that had a combination of ethanol and clozapine orally in the above doses were examined 3 hours after intoxication. Those from 18 rats that had been orally given the similar agents in the above doses and withdrawn from the experiment were also investigated 24 hours after drug administration. The sections were compared with those from 6 rats that had not received the above agents. Nonparametric methods (χ2 test) were used for statistical processing. The investigators assessed the following morphological signs: circulatory disorders (plethora, hemorrhages), interstitial and alveolar edema, damage to the bronchial and alveolar epithelium and to the endothelium, and a cell reaction. The differences were considered significant at p&lt;0.05. Results. In the control animal group, histological examination did not reveal any circulatory disorders and damage to the bronchial and alveolar epithelium and to the endothelium. Three hours after its administration, the animals that had received clozapine were observed to have acute pulmonary circulatory disorders (plethora in the pulmonary artery system, focal plethora of the capillaries of interalveolar septa and that of veins) that increased 24 hours after its ingestion. If death occurred 3 hours after ethanol intake, there was obvious perivascular edema, plethora, and hemorrhage; some alveoli contained transudate. Moderate venous plethora was seen 24 hours following ethanol administration. The secretory activity of the bronchial mucosa decreased. Three hours after coadministration of clozapine and ethanol, there were acute pulmonary circulatory disorders (marked plethora, multiple hemorrhages, and alveolar edema), bronchial epithelial lesion (desquamation), and no staining of endothelial cell nuclei. Lymphocyte accumulation was observed around the veins and arteriovenous anastomoses. Perivascular edema was absent. The lesions increased 24 hours after coadministration of clozapine and ethanol. Conclusion. The changes found at lung histological examination of the animals receiving clozapine alone and its combination with ethanol in conjunction with the results of forensic chemical analysis may be used to diagnose relevant intoxications and to establish their duration. © 2015 AVES Ibrahim Kara. All rights reserved

ВСЕРОССИЙСКАЯ НАУЧНО-ПРАКТИЧЕСКАЯ КОНФЕРЕНЦИЯ “ДЕКАБРЬСКИЕ ЧТЕНИЯ ПО СУДЕБНОЙ МЕДИЦИНЕ В РУДН: АКТУАЛЬНЫЕ ВОПРОСЫ СУДЕБНОЙ МЕДИЦИНЫ И АНЕСТЕЗИОЛОГИИ-РЕАНИМАТОЛОГИИ”

This article contains information on the Scientific Conference, brief content of the reports.В статье приводится информация о проведенной научно-практической конференции, дано краткое содержание представленных докладов

Assessment of lung morphological changes in acute intoxications with clozapine, ethanol and their combination

Objective: to detect lung morphological changes in acute intoxications with clozapine, ethanol, and their combination 3 and 24 hours after poisoning. Materials and methods. Experiments were carried out in outbred male rats weighing 270–300 g. Clozapine was given in a dose of 250 mg per kg animal body weight under chloralose anesthesia. Following 3 and 24 hours, the animals were withdrawn from the experiment by decapitation. Lung histological sections from 6 rats that had received oral clozapine 250 mg/kg, 6 rats that had oral ethanol 8.6 ml/kg, and 6 rats that had a combination of ethanol and clozapine orally in the above doses were examined 3 hours after intoxication. Those from 18 rats that had been orally given the similar agents in the above doses and withdrawn from the experiment were also investigated 24 hours after drug administration. The sections were compared with those from 6 rats that had not received the above agents. Nonparametric methods (χ2 test) were used for statistical processing. The investigators assessed the following morphological signs: circulatory disorders (plethora, hemorrhages), interstitial and alveolar edema, damage to the bronchial and alveolar epithelium and to the endothelium, and a cell reaction. The differences were considered significant at p&lt;0.05. Results. In the control animal group, histological examination did not reveal any circulatory disorders and damage to the bronchial and alveolar epithelium and to the endothelium. Three hours after its administration, the animals that had received clozapine were observed to have acute pulmonary circulatory disorders (plethora in the pulmonary artery system, focal plethora of the capillaries of interalveolar septa and that of veins) that increased 24 hours after its ingestion. If death occurred 3 hours after ethanol intake, there was obvious perivascular edema, plethora, and hemorrhage; some alveoli contained transudate. Moderate venous plethora was seen 24 hours following ethanol administration. The secretory activity of the bronchial mucosa decreased. Three hours after coadministration of clozapine and ethanol, there were acute pulmonary circulatory disorders (marked plethora, multiple hemorrhages, and alveolar edema), bronchial epithelial lesion (desquamation), and no staining of endothelial cell nuclei. Lymphocyte accumulation was observed around the veins and arteriovenous anastomoses. Perivascular edema was absent. The lesions increased 24 hours after coadministration of clozapine and ethanol. Conclusion. The changes found at lung histological examination of the animals receiving clozapine alone and its combination with ethanol in conjunction with the results of forensic chemical analysis may be used to diagnose relevant intoxications and to establish their duration. © 2015 AVES Ibrahim Kara. All rights reserved

ХАРАКТЕРИСТИКА ГИСТОМОРФОЛОГИЧЕСКИХ ИЗМЕНЕНИЙ В СЕРДЦЕ ПРИ ОТРАВЛЕНИИ КЛОЗАПИНОМ

The article deals with the features of histomorphological changes in the heart in poisoning with atypical neuroleptic - clozapine. The relevance of the topic is caused by the large number of poisoning by this substance. The authors conducted a study of heart histological sections of 10 rats treated with clozapine at a dosage of 150 mg / kg in order to assess changes in them. The sections were compared with histological sections of the heart of intact animals (5). The hidtomorphological changes revealed in heart along with the hismimorphological changes in other organs and the results of chemical analysis will hallow to diagnose clozapine poisonings.В статье рассмотрены особенности гистоморфологических изменений в сердце при отравлении атипичным нейролептиком - клозапином. Актуальность темы обусловлена большим количеством отравлений этим веществом. Авторы провели исследование гистологических препаратов сердца 10 подопытных крыс, получавших клозапин в дозе 150 мг/кг с целью оценки изменений в них. Сравнение проводилось с гистологическими срезами сердца интактных животных. Выявлен- ные гистоморфологические изменения в сердце вместе с изменениями в других органах и результатами судебно-химического исследования позволят диагностировать отравления клозапином