1 research outputs found
Design and Synthesis of Novel <sup>19</sup>F‑Amino Acid: A Promising <sup>19</sup>F NMR Label for Peptide Studies
Novel
aliphatic <sup>19</sup>F-substituted amino acid was designed
as a <sup>19</sup>F NMR label for peptide studies. The synthesis was
performed in 11 steps and 9% overall yield from a commercially available
starting material. The key transformation was a decarboxylative fluorination
of an aliphatic carboxylic acid with XeF<sub>2</sub> in C<sub>6</sub>F<sub>6</sub>