Polarization-resolved second-harmonic-generation optical coherence tomography in collagen

We describe a novel imaging technique, second-harmonic-generation optical coherence tomography (SHOCT). This technique combines the spatial resolution and depth penetration of optical coherence tomography (OCT) with the molecular sensitivity of second-harmonic-generation spectroscopy. As a consequence of the coherent detection required for OCT, polarization-resolved images arise naturally. We demonstrate this new technique on a skin sample from the belly of Icelandic salmon, acquiring polarization-resolved SHOCT and OCT images simultaneously

Champagne Flutes and Brandy Snifters: Modelling Protostellar Outflow-Cloud Chemical Interfaces

A rich variety of molecular species has now been observed towards hot cores in star forming regions and in the interstellar medium. An increasing body of evidence from millimetre interferometers suggests that many of these form at the interfaces between protostellar outflows and their natal molecular clouds. However, current models have remained unable to explain the origin of the observational bias towards wide-angled "brandy snifter" shaped outflows over narrower "champagne flute" shapes in carbon monoxide imaging. Furthermore, these wide-angled systems exhibit unusually high abundances of the molecular ion HCO$^+$. We present results from a chemo-dynamic model of such regions where a rich chemistry arises naturally as a result of turbulent mixing between cold, dense molecular gas and the hot, ionized outflow material. The injecta drives a rich and rapid ion-neutral chemistry in qualitative and quantitative agreement with the observations. The observational bias towards wide-angled outflows is explained naturally by the geometry-dependent ion injection rate causing rapid dissociation of CO in the younger systems.Comment: Accepted to MNRAS. 12 pages, 8 Figure

Rapid testing may not improve uptake of HIV testing and same day results in a rural South African community: a cohort study of 12,000 women

<p>Background: Rapid testing of pregnant women aims to increase uptake of HIV testing and results and thus optimize care. We report on the acceptability of HIV counselling and testing, and uptake of results, before and after the introduction of rapid testing in this area.</p> <p>Methods and Principal Findings: HIV counsellors offered counselling and testing to women attending 8 antenatal clinics, prior to enrolment into a study examining infant feeding and postnatal HIV transmission. From August 2001 to April 2003, blood was sent for HIV ELISA testing in line with the Prevention of Mother-to-Child Transmission (PMTCT) programme in the district. From May 2003 to September 2004 women were offered a rapid HIV test as part of the PMTCT programme, but also continued to have ELISA testing for study purposes. Of 12,323 women counselled, 5,879 attended clinic prior to May 2003, and 6,444 after May 2003 when rapid testing was introduced; of whom 4,324 (74.6%) and 4,810 (74.6%) agreed to have an HIV test respectively. Of the 4,810 women who had a rapid HIV test, only 166 (3.4%) requested to receive their results on the same day as testing, the remainder opted to return for results at a later appointment. Women with secondary school education were less likely to agree to testing than those with no education (AOR 0.648, p<0.001), as were women aged 21–35 (AOR 0.762, p<0.001) and >35 years (AOR 0.756, p<0.01) compared to those <20 years.</p> <p>Conclusions: Contrary to other reports, few women who had rapid tests accepted their HIV results the same day. Finding strategies to increase the proportion of pregnant women knowing their HIV results is critical so that appropriate care can be given.</p&gt

Laser driven launch vehicles for continuous access to space

The availability of megawatt laser systems in the next century will make laser launch systems from ground to orbit feasible and useful. Systems studies indicate launch capabilities of 1 ton payload per gigawatt laser power. Recent research in ground to orbit laser propulsion has emphasized laser supported detonation wave thrusters driven by repetitively pulsed infrared lasers. In this propulsion concept each laser repetition cycle consists of two pulses. A lower energy first pulse is used to vaporize a small amount of solid propellant and then after a brief expansion period, a second and higher energy laser pulse is used to drive a detonation wave through the expanded vapor. The results are reported of numerical studies comparing the detonation wave properties of various candidate propellants, and the simulation of thruster performance under realistic conditions. Experimental measurements designed to test the theoretical predictions are also presented. Measurements are discussed of radiance and opacity in absorption waves, and mass loss and momentum transfer. These data are interpreted in terms of specific impulse and energy conversion efficiency

Full-Scale Lateral Load Testing of Deep Foundations Using Blast-Induced Liquefaction

To improve our understanding of the lateral load behavior of deep foundations in liquefied soil, a series of full-scale lateral load tests have been performed at the National Geotechnical Experimentation Site (NGES) at Treasure Island in San Francisco, California. The ground around the test piles was liquefied using explosives prior to lateral load testing. The goal of the project is to develop load-displacement relationships for bored and driven piles and pile groups in liquefied sand under full-scale conditions for improved and non-improved ground. The results of this investigation confirmed that controlled blasting techniques could successfully be used to induce liquefaction in a well-defined, limited area for field-testing purposes. Excess pore pressure ratios greater than 0.8 were typically maintained for 4 to 10 minutes after blasting. Data were collected showing the behavior of laterally loaded piles before and after liquefaction in non-improved ground. Following liquefaction, the stiffness of the soil-foundation system typically decreased by 70 to 80% of its pre-liquefaction value non-improved ground. Ground improvement with stone columns was then performed prior to an additional series of tests. Lateral load tests were again conducted before and after blasting to induce liquefaction. Cone penetration testing following the installation of stone columns found that the density was improved significantly. As a result, the stiffness of the foundation system following blasting was 2.9 to 3.6 times that in the liquefied soil. Subsequent tests involving more than twice as many piles or 50% larger piles provided less than 50% of the increased resistance produced by stone column treatment alone. This study provides some of the first full-scale quantitative results on the improvement of foundation performance due to ground improvement in a liquefiable deposit

Plasduino: an inexpensive, general purpose data acquisition framework for educational experiments

Based on the Arduino development platform, Plasduino is an open-source data acquisition framework specifically designed for educational physics experiments. The source code, schematics and documentation are in the public domain under a GPL license and the system, streamlined for low cost and ease of use, can be replicated on the scale of a typical didactic lab with minimal effort. We describe the basic architecture of the system and illustrate its potential with some real-life examples.Comment: 11 pages, 10 figures, presented at the XCIX conference of the Societ\`a Italiana di Fisic

Parasitic Eyeworm (Oxyspirura Petrowi) in Northern Bobwhites from the Rolling Plains of Texas, 2007–2011

The eyeworm Oxyspirura petrowi is an indirect life cycle nematode that occurs under the nictitating membrane on the eye surface of certain bird species. Previous studies from western or northwestern regions of Texas reported O. petrowi from northern bobwhites (Colinus virginianus), scaled quail (Callipepla squamata), and Montezuma quail (Cyrtonyx montezumae). We examined 173 bobwhites from the Rolling Plains of Texas collected during the 2007–2008 (n 1⁄4 33), 2009–2010 (n 1⁄4 86), and 2010–2011 (n 1⁄4 54) hunting seasons, respectively. Overall, 99 (57%) bobwhites were infected with 596 individual O. petrowi; the mean (6 SD) eyeworm intensity was 6.0 6 6.4 (range 1⁄4 1–40) and mean abundance was 3.4 6 5.7. Thus, this eyeworm is a commonly occurring parasite of bobwhites in the Rolling Plains of Texas. Additional surveys are needed to learn more about the geographic distribution of O. petrowi and to assess the possible negative effects on individual bobwhites and their populations

Innovations in Spacecraft Proximity & Navigation Lighting

New spacecraft bound for the Moon and Mars should be exploring lighting technologies that can reduce safety risks while increasing capability. The operational lighting environment for these new missions will not have the forgiving 90 minute orbit of the International Space Station. Advances in solid state lighting and optics design are yielding new form factors for lamps that have the potential to reduce operational risk for both humans and imaging systems that are impacted by high contrast lighting environments. This project evaluated light source form factors and control innovations for spacecraft exterior proximity and navigation lighting by building a demonstration test rig and testing the effectiveness of the light sources and their controls to increase visibility and usability

Using digital and hand printing techniques to compensate for loss: re-establishing colour and texture in historic textiles

Conservators use a range of 'gap filling' techniques to improve the structural stability and presentation of objects. Textile conservators often use fabric supports to provide reinforcement for weak areas of a textile and to provide a visual infill in missing areas. The most common technique is to use dyed fabrics of a single colour but while a plain dyed support provides good reinforcement, it can be visually obtrusive when used with patterned or textured textiles. Two recent postgraduate dissertation projects at the Textile Conservation Centre (TCC) have experimented with hand printing and digital imaging techniques to alter the appearance of support fabrics so that they are less visually obtrusive and blend well with the colour and texture of the textile being supported. Case studies demonstrate the successful use of these techniques on a painted hessian rocking horse and a knitted glove from an archaeological context