Lifelong Learning for Information Systems Professionals

A quarter century ago, Toffler (1970) speculated that the rate at which changes took place was increasing at an ever-faster pace. He surmised that this was creating a more complex environment with greater uncertainty for individuals and organizations. Since his prediction, the business world has surely experienced immense changes that have seemed to occur with increasing frequency. Product life cycles have been drastically shortened in many industries. Globalization of the marketplace has taken place in a very short time span. Fluctuating prices for raw materials and energy, currency volatility, industry deregulation, and a host of other transformations have all contributed to an increasingly complex competitive environment. These changes havehad a major impact on the practice of information systems and on the careers of professionals. We will argue in this paper that the changes necessitate a complete reengineering of information systems curricula and teaching method

Home care—a safe and attractive alternative to inpatient administration of intensive chemotherapies

Objective: The objective of this study was to evaluate feasibility, safety, perception, and costs of home care for the administration of intensive chemotherapies. Methods: Patients receiving sequential chemotherapy in an inpatient setting, living within 30km of the hospital, and having a relative to care for them were offered home care treatment. Chemotherapy was administered by a portable, programmable pump via an implantable catheter. The main endpoints were safety, patient's quality of life [Functional Living Index—Cancer (FLIC)], satisfaction of patients and relatives, and costs. Results: Two hundred days of home care were analysed, representing a total of 46 treatment cycles of intensive chemotherapy in 17 patients. Two cycles were complicated by technical problems that required hospitalisation for a total of 5days. Three major medical complications (heart failure, angina pectoris, and major allergic reaction) could be managed at home. Grades 1 and 2 nausea and vomiting occurring in 36% of patients could be treated at home. FLIC scores remained constant throughout the study. All patients rated home care as very satisfactory or satisfactory. Patient benefits of home care included increased comfort and freedom. Relatives acknowledged better tolerance and less asthenia of the patient. Home care resulted in a 53% cost benefit compared to hospital treatment (€420 ± 120/day vs. €896 ± 165/day). Conclusion: Administration of intensive chemotherapy regimens at home was feasible and safe. Quality of life was not affected; satisfaction of patients and relatives was very high. A psychosocial benefit was observed for patients and relatives. Furthermore, a cost-benefit of home care compared to hospital treatment was demonstrate

DNA Vaccine-Generated Duck Polyclonal Antibodies as a Postexposure Prophylactic to Prevent Hantavirus Pulmonary Syndrome (HPS)

Andes virus (ANDV) is the predominant cause of hantavirus pulmonary syndrome (HPS) in South America and the only hantavirus known to be transmitted person-to-person. There are no vaccines, prophylactics, or therapeutics to prevent or treat this highly pathogenic disease (case-fatality 35–40%). Infection of Syrian hamsters with ANDV results in a disease that closely mimics human HPS in incubation time, symptoms of respiratory distress, and disease pathology. Here, we evaluated the feasibility of two postexposure prophylaxis strategies in the ANDV/hamster lethal disease model. First, we evaluated a natural product, human polyclonal antibody, obtained as fresh frozen plasma (FFP) from a HPS survivor. Second, we used DNA vaccine technology to manufacture a polyclonal immunoglobulin-based product that could be purified from the eggs of vaccinated ducks (Anas platyrhynchos). The natural “despeciation" of the duck IgY (i.e., Fc removed) results in an immunoglobulin predicted to be minimally reactogenic in humans. Administration of ≥5,000 neutralizing antibody units (NAU)/kg of FFP-protected hamsters from lethal disease when given up to 8 days after intranasal ANDV challenge. IgY/IgYΔFc antibodies purified from the eggs of DNA-vaccinated ducks effectively neutralized ANDV in vitro as measured by plaque reduction neutralization tests (PRNT). Administration of 12,000 NAU/kg of duck egg-derived IgY/IgYΔFc protected hamsters when administered up to 8 days after intranasal challenge and 5 days after intramuscular challenge. These experiments demonstrate that convalescent FFP shows promise as a postexposure HPS prophylactic. Moreover, these data demonstrate the feasibility of using DNA vaccine technology coupled with the duck/egg system to manufacture a product that could supplement or replace FFP. The DNA vaccine-duck/egg system can be scaled as needed and obviates the necessity of using limited blood products obtained from a small number of HPS survivors. This is the first report demonstrating the in vivo efficacy of any antiviral product produced using DNA vaccine-duck/egg system

Objets et fabrication du genre

Qu'est-ce que les objets ont à apprendre aux historiennes et historiens qui cherchent à mieux comprendre les dynamiques du genre ? Ce numéro de Clio HGF « Objets et fabrication du genre » tente de répondre à cette interrogation. En insistant sur la spécificité de la culture matérielle des temps bibliques au très contemporain, les auteur.e.s analysent des mouchoirs politiques, des uniformes de soldat, des bijoux, des jouets publicitaires, de la vaisselle, des fragments de tissu et de poteries, mais aussi des représentations littéraires et visuelles… À partir de ces approches et de ces sources variées, les articles montrent comment les femmes et les hommes se construisent grâce aux objets, comment l'objet-acteur construit le genre, comment les objets nous racontent une autre histoire que les mots