Comparison of methods for partitioning training and validation populations to optimize prediction accuracy and enable across-breed genomic selection in beef cattle

Title from PDF of title page (University of Missouri--Columbia, viewed on July 29, 2013).The entire thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file; a non-technical public abstract appears in the public.pdf file.Dissertation advisor: Dr. Jeremy F. TaylorIncludes bibliographical references.Vita.Ph. D. University of Missouri--Columbia 2012.Dissertations, Academic -- University of Missouri--Columbia -- Genetics area program."July 2012"Across-breed genomic selection practices have the potential to revolutionize national genetic evaluation systems in the United States by including commercial cattle and increasing prediction power for hybrid animals. We used a population of 3,240 animals from the Carcass Merit Project to build across-breed genomic selection models for six carcass and four sensory panel traits across five breeds of commercially relevant beef cattle (Angus, Charolais, Hereford, Limousin, and Simmental). Allocation of these animals to training or validation populations based on genetic distance measures or genomic relationships coefficients proved to be no more effective than random allocation of animals. Realized accuracies in these populations showed that the prediction models were very effective when used on animals within the same project and short time span (0.41-0.78). When used in an external validation in animals separated by approximately 10 years, prediction accuracies showed severe reductions (from ~0.6 down to 0.05), indicating that retraining of prediction models will have to be done frequently (possibly annually) in commercial populations. We also identified numerous regions of the genome which showed evidence of harboring causal mutations for these traits of economic importance. These regions will serve as independent validations in the literature as well as a guidepost for researchers looking for causal mutations within the bovine genome.Includes bibliographical reference

Interpreting equine genetic defect testing results

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DNA sample collection

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Understanding EPD accuracies

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Using genomics part II: Risk management of genetic defects

The Oklahoma Cooperative Extension Service periodically issues revisions to its publications. The most current edition is made available. For access to an earlier edition, if available for this title, please contact the Oklahoma State University Library Archives by email at [email protected] or by phone at 405-744-6311

Using genomics part I: What are DNA markers?

The Oklahoma Cooperative Extension Service periodically issues revisions to its publications. The most current edition is made available. For access to an earlier edition, if available for this title, please contact the Oklahoma State University Library Archives by email at [email protected] or by phone at 405-744-6311

Color patterns in crossbred beef cattle

The Oklahoma Cooperative Extension Service periodically issues revisions to its publications. The most current edition is made available. For access to an earlier edition, if available for this title, please contact the Oklahoma State University Library Archives by email at [email protected] or by phone at 405-744-6311

Ten tips for utilizing a cattle sale catalog

The Oklahoma Cooperative Extension Service periodically issues revisions to its publications. The most current edition is made available. For access to an earlier edition, if available for this title, please contact the Oklahoma State University Library Archives by email at [email protected] or by phone at 405-744-6311

Calculating across-breed EPDs

The Oklahoma Cooperative Extension Service periodically issues revisions to its publications. The most current edition is made available. For access to an earlier edition, if available for this title, please contact the Oklahoma State University Library Archives by email at [email protected] or by phone at 405-744-6311