Economic Perspective for Agricultural Biotechnology Research Planning

There is no other agricultural technology that has been subjected to a lot of controversies than agricultural biotechnology. More than ever, intelligent decisions about this technology would be based on scientific data and objective analyses. As we meet the challenges of food security in a sustainable way, and given the very limited land and energy resources; available alternatives are few. Because of its unique features, the economic study in biotechnology deviates from the standard economic impact of technological changes, such as mechanization. It is more closely related to measuring the impact of pesticides, though the issue of Intellectual Property Rights (IPR) has not been raised in the chemical technology. In addition, just like pesticides, some biotechnology products have externality effects. Thus the economic framework for its analysis will be consistent with the issues about the economics of sustainability, which has long-term benefits/costs and considered to be very knowledge intensive for both farmers and other handlers. Some of the features that could impinge on the economic issues of agricultural biotechnology are the private-public sector partnership in research, development, and technology transfer; the role of the IPRs in both technology development and transfer; the regulations about biosafety and other licensing requirements for ultimate commercialization; and the management of the technology once in the market and in the farmers fields. These could affect the cost and the output price structure. The ex ante economic analysis could guide us in the measurement of potential effectiveness and efficiency of biotechnology, and in general, in the research prioritization

Use of multiple singular value decompositions to analyze complex intracellular calcium ion signals

We compare calcium ion signaling ($\mathrm {Ca}^{2+}$) between two exposures; the data are present as movies, or, more prosaically, time series of images. This paper describes novel uses of singular value decompositions (SVD) and weighted versions of them (WSVD) to extract the signals from such movies, in a way that is semi-automatic and tuned closely to the actual data and their many complexities. These complexities include the following. First, the images themselves are of no interest: all interest focuses on the behavior of individual cells across time, and thus, the cells need to be segmented in an automated manner. Second, the cells themselves have 100$+$ pixels, so that they form 100$+$ curves measured over time, so that data compression is required to extract the features of these curves. Third, some of the pixels in some of the cells are subject to image saturation due to bit depth limits, and this saturation needs to be accounted for if one is to normalize the images in a reasonably unbiased manner. Finally, the $\mathrm {Ca}^{2+}$ signals have oscillations or waves that vary with time and these signals need to be extracted. Thus, our aim is to show how to use multiple weighted and standard singular value decompositions to detect, extract and clarify the $\mathrm {Ca}^{2+}$ signals. Our signal extraction methods then lead to simple although finely focused statistical methods to compare $\mathrm {Ca}^{2+}$ signals across experimental conditions.Comment: Published in at http://dx.doi.org/10.1214/09-AOAS253 the Annals of Applied Statistics (http://www.imstat.org/aoas/) by the Institute of Mathematical Statistics (http://www.imstat.org

Using Community-Generated Data for Water Management Policy

This Policy Notes documents the experience of Lantapan, a watershed community in Bukidnon, where data collected by a community-based group to monitor its watershed's quality through the years helped alert the local government on the critical state of their water resources, thereby helping avert a possible water crisis. At the same time, the findings indicate the urgency to have a consistency of policies at both the national and local levels in order to ensure a more effective, efficient and sustainable management of natural resources, especially water resources.watershed, water resource management, water quality

Realities of Watershed Management in the Philippines: Synthesis of Case Studies

This paper presents a synthesis of four case studies of watershed management experiences in the Philippines, primarily to provide insight on why watershed management approach has not gained wider recognition in the country despite being renowned internationally. A brief description was presented for each case study involving the watersheds of Maasin, Magat, Manupali, and Balian sub-watershed to account for their critical role as water supply support systems to downstream communities. It provides highlights on various initiatives undertaken by the Local government Units, NGOs, private sector etc. in their effort to protect these watersheds from environmental degradation. The case studies have shown that the effective implementation of watershed management requires some level of financial capital, a community or group of communities with good enough level of intellectual and social capitals, and the presence of a legal and institutional framework to support the watershed approach. The level of these various forms of capital vary across watershed, thereby leading to differences in the level of watershed management implementation as well. The study also puts forward the need for payments of environmental services as previous initiatives undertaken by national forest protection programs and other community-based livelihood activities and reforestation projects are just short-lived management initiatives

The Host Galaxy of GRB980703 at Radio Wavelengths - a Nuclear Starburst in a ULIRG

We present radio observations of GRB980703 at 1.43, 4.86, and 8.46 GHz for the period of 350 to 1000 days after the burst. These radio data clearly indicate that there is a persistent source at the position of GRB980703 with a flux density of approximately 70 $\mu$Jy at 1.43 GHz, and a spectral index, $\beta\approx 0.32$, where $F_\nu\propto \nu^{-\beta}$. We show that emission from the afterglow of GRB980703 is expected to be one to two orders of magnitude fainter, and therefore cannot account for these observations. We interpret this persistent emission as coming from the host galaxy --- the first example of a gamma-ray burst (GRB) host detection at radio wavelengths. We show that emission from an AGN is unlikely, and find that it can be explained as a result of a star-formation rate (SFR) of massive stars (M>5M$_\odot$) of 90 M$_\odot$/yr, which gives a total SFR of $\approx 500$ M$_\odot$/yr. Using the correlation between the radio and far-IR (FIR) luminosities of star-forming galaxies, we find that the host of GRB980703 is at the faint end of the class of Ultra Luminous Infrared Galaxies (ULIRGs), with L_{FIR}\sim few\times 10^{12} L$_\odot$. From the radio measurements of the offset between the burst and the host, and the size of the host, we conclude that GRB980703 occurred near the center of the galaxy in a region of maximum star formation. A comparison of the properties of this galaxy with radio and optical surveys at a similar redshift ($z\approx 1$) reveals that the host of GRB980703 is an average star-forming galaxy. This result has significant implications for the potential use of a GRB-selected galaxy sample for the study of galaxies and the IGM at high redshifts.Comment: Submitted to Ap

Realities of the Watershed Management Approach: The Manupali Watershed Experience

Local research in the Manupali watershed, with about 60% of its land area belonging to the upland municipality of Lantapan, Bukidnon, found that water quantity and quality declined due to soil erosion and domestic waste contamination. As population grows and agriculture becomes more integrated to the market, water deterioration is projected to worsen. Both economic and environmental sustainability then depend on the following management bodies: 1) the management of the Mt. Kitanglad range, the headwaters of the Manupali, 2) management of the tributaries that are within the agricultural areas of Lantapan and 3) the management of the bigger watershed cluster to where Manupali belongs. The first two management entities have management plans in place; with some funding pledges for the Mt. Kitanglad Range Natural Park (a protected area by law) Management Plan. The Lantapan municipality watershed management plan still needs funding support and an institutional body that can implement said plans. The bigger watershed cluster plan(Upper Pulangi) is being developed and success in the management depends in part on the commitment of the several communities that compose this cluster. Some of the challenges that were identified in implementing the several watershed management plans charged with sustainability of the Manupali are financial sustainability, limited economic instruments, weak property rights, lack of administrative mechanisms, human capital and institutional constraints, and a legal basis for the management structure

Adhesion-independent synergy of monocytes and endothelial cells in cytokine production: regulation of IL-6 and GM–CSF production by PAF

Co-Cultures of monocytes (MO) and endothelial cells (EC) were studied for their capacity to synergize in the production of interleukin-6 (IL-6) and granulocyte-macrophage colony-stimulating factor (GM–CSF), two cytokines potentially important in vascular physiopathology. Resting monocytes produced detectable amounts of IL-6 but no GM–CSF, whereas confluent EC produced significant quantities of GM–CSF, but minimal IL-6. In co-cultures without stimuli, additive synthesis of both cytokines was observed. When EC were pretreated, however, with either PAF, TNF or both stimuli, before addition of MO, synergistic production of IL-6 was observed. In contrast, GM–CSF production was not enhanced by coculture of monocytes with activated EC. When either cell population was fixed with paraformaldehyde or killed by freeze-thawing before addition to the co-culture, cytokine levels reverted to those produced by the unaffected population alone. On the other hand, separating the two cell populations by a cell-impermeable membrane in transwell cultures did not affect the synergistic production of the cytokines. Taken together, our data suggest that EC and MO can synergize in response to stimuli by producing IL-6 and that this synergy is dependent on the integrity of both cell populations, but independent of cell-cell contact

Research Program Planning for Natural Resource Management: A Background Analysis

Conventionally, agricultural resource management per se is not a popular area of research. Agricultural production research was crop and input specific. Earlier studies recommended fertilizer levels that maximize yields; or cropping patterns that maximize output and profits. Water was considered a fixed input; water productivity was not an issue, so was soil productivity. A review of the results of studies on soil and water conducted in the 1980s and the 1990s showed deficiencies in taking into account the optimal management of these agricultural resources that could have assured sustainable productivity impacts. For soil management for instance, there is a need to unravel that black box of the processes on how farmers decide in agricultural resource management. It is a well known fact that information is the most important input in sustainable agriculture. How do farmers handle this information? What are their knowledge bases? For water management, the issue is about water productivity. This is however, a function of water quantity, quality, and water delivery efficiency. Agricultural decision makers should take active part in the management of the watershed as a significant source of surface water for irrigation. But we also have to guard our shallow groundwater from the environmental pollutants that could affect its utility in agriculture. The current debate by experts on the optimal combination of two sources of irrigation water, i.e. surface water and groundwater, should also be taken into consideration. Finally, the most efficient mode of delivery should be studied. Research on soil and water is numerous. However, the fact that we still observe a lot of resource degradation implies that the desired impact in terms of sustainability outcomes of all these, is not attained. Maybe, a reexamination of the context in which we design soil and water management research agenda, and the process of filtering the results to people who actually use and /or decide on use of the resource is the first item of study. In this regard, an alternative research paradigm for natural resource management (NRM) is proposed. NRM research will go beyond commodities and beyond disciplines. NRM research should be treated from the watershed scale; and take into account the broad range of stakeholders that will be affected and the role of the institutions in the process. Some of the recorded products of research on NRM are actually based on indigenous farmer knowledge. It is only with the building up of the farmer knowledge bases that research can make an impact on farmers practices. Moreover, diagnostics and other farmer/extension friendly kits have to be developed and used as early warning devices. How do farmers learn about these knowledge intensive technologies (KIT)? And also, the role of the various institutions in the promotion or in the constraint to adoption of sustainable technologies should be noted. NRM research is not to be confined to the study of agriculture technologies or the environmental management alone; but rather to the broader, intersectoral linkages that potentially affect farmer behaviour and farmer land use and technology decisions

Abundance Profiles and Kinematics of Damped Lyman-alpha Absorbing Galaxies at z < 0.65

We present a spectroscopic study of six damped Lya absorption (DLA) systems at z<0.65, based on moderate-to-high resolution spectra of the galaxies responsible for the absorbers. Combining known metallicity measurements of the absorbers with known optical properties of the absorbing galaxies, we confirm that the low metal content of the DLA population can arise naturally as a combination of gas cross-section selection and metallicity gradients commonly observed in local disk galaxies. We also study the Tully-Fisher relation of the DLA-selected galaxies and find little detectable evidence for evolution in the disk population between z=0 and z~0.5. Additional results of our analysis are as follows. (1) The DLA galaxies exhibit a range of spectral properties, from post-starburst, to normal disks, and to starburst systems, supporting the idea that DLA galaxies are drawn from the typical field population. (2) Large rotating HI disks of radius 30 h^{-1} kpc and of dynamic mass M_dyn > 10^{11} h^{-1} M_sun appear to be common at intermediate redshifts. (3) Using an ensemble of six galaxy-DLA pairs, we derive an abundance profile that is characterized by a radial gradient of -0.041 +/- 0.012 dex per kiloparsec (or equivalently a scale length of 10.6 h^{-1} kpc) from galactic center to 30 h^{-1} kpc radius. (4) Adopting known N(HI) profiles of nearby galaxies and the best-fit radial gradient, we further derive an N(HI)-weighted mean metallicity _weighted = -0.50 +/- 0.07 for the DLA population over 100 random lines of sight, consistent with _weighted = -0.64 (-0.86, +0.40) observed for z~1 DLA systems from Prochaska et al. Our analysis demonstrates that the low metal content of DLA systems does not rule out the possibility that the DLA population trace the field galaxy population.Comment: 57 pages, 17 figures, to appear in the ApJ 20 February 2005 issue; a pdf version of the paper with full-resolution figures is available at http://falcon.mit.edu/~hchen/public/tmp/dlachem.pd