Implantación de una herramienta ERP con licencia GPL y desarrollo del anexo transaccional para la empresa DIPROMAC.

El software libre permite la libertad del conocimiento ya que podemos estudiar su arquitectura, el código fuente y realizar modificaciones en el mismo.El presente trabajo de investigación ha sido elaborado con la finalidad de brindar una solución da la empresa de distribución de leche DIPROMAC de la ciudad de Ibarra referente a la falta de sistema ERP (sistemas de información gerenciales) con licencia general pública (GLP) que permita el manejo integral de los procesos comerciales de la empresa y el desarrollo de un módulo a adicional dentro del ERP que permita genera el anexo transaccional. Mediante los requerimientos de la empresa se ha seleccionado un sistema ERP basado en software libre más adaptable y sobre este sistema mediante estudio de la arquitectura, base de datos y código fuente se ha desarrollado un nuevo módulo para generar el anexo transaccional

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality