45 research outputs found
Kerman-Klein-Donau-Frauendorf model for odd-odd nuclei: formal theory
The Kerman-Klein-Donau-Frauendorf (KKDF) model is a linearized version of the
Kerman-Klein (equations of motion) formulation of the nuclear many-body
problem. In practice, it is a generalization of the standard core-particle
coupling model that, like the latter, provides a description of the
spectroscopy of odd nuclei in terms of the properties of neighboring even
nuclei and of single-particle properties, that are the input parameters of the
model. A divers sample of recent applications attest to the usefulness of the
model. In this paper, we first present a concise general review of the
fundamental equations and properties of the KKDF model. We then derive a
corresponding formalism for odd-odd nuclei that relates their properties to
those of four neighboring even nuclei, all of which enter if one is to include
both multipole and pairing forces. We treat these equations in two ways. In the
first we make essential use of the solutions of the neighboring odd nucleus
problem, as obtained by the KKDF method. In the second, we relate the
properties of the odd-odd nuclei directly to those of the even nuclei. For both
choices, we derive equations of motion, normalization conditions, and an
expression for transition amplitudes. We also solve the problem of choosing the
subspace of physical solutions that arises in an equations of motion approach
that includes pairing interactions.Comment: 27 pages, Late
New results for the missing quantum numbers labeling the quadrupole and octupole boson basis
The many -pole boson states, with ,
realize the irreducible representation (IR) for the group reduction chains
. They have been analytically
studied and widely used for the description of nuclear systems. However, no
analytical expression for the degeneracy of the 's IR,
determined by the reduction , is available. Thus, the
number of distinct values taken by has been so far obtained by
solving some complex equations. Here we derive analytical expressions for the
degeneracy characterizing the octupole and quadrupole boson states,
respectively. The merit of this work consists of the fact that it completes the
analytical expressions for the -pole boson basis.Comment: 10page
Parametrizations of triaxial deformation and E2 transitions of the wobbling band
By the very definition the triaxial deformation parameter is related
to the expectation values of the K=0 and K=2 components of the intrinsic
quadrupole tensor operator. On the other hand, using the same symbol
"", various different parametrizations of triaxial deformation have
been employed, which are suitable for various types of the mean-field
potentials. It is pointed out that the values of various "" are quite
different for the same actual triaxial deformation, especially for the large
deformation; for example, the difference can be almost a factor two for the
case of the triaxial superdeformed bands recently observed in the Hf and Lu
nuclei. In our previous work, we have studied the wobbling band in Lu nuclei by
using the microscopic framework of the cranked Nilsson mean-field and the
random phase approximation, where the most serious problem is that the
calculated B(E2) value is about factor two smaller. It is shown that the origin
of this underestimation can be mainly attributed to the small triaxial
deformation; if is used the same triaxial deformation as in the analysis of the
particle-rotor model, the calculated B(E2) increases and gives correct
magnitude compared with the experimental data.Comment: 10 pages, 9 figure
Collective Quadrupole Excitations in Transitional Nuclei
The generalized Bohr Hamiltonian was used to describe the low-lying collective excitations in even-even isotopes of Ru, Pd, Te, Ba and Nd. The Strutinsky collective potential and cranking inertial functions were obtained using the Nilsson potential. The effect of coupling with the pairing vibrations is taken into account approximately when determining the inertial functions. The calculation does not contain any free parameter
Breaking and restoring symmetries within the nuclear energy density functional method
We review the notion of symmetry breaking and restoration within the frame of
nuclear energy density functional methods. We focus on key differences between
wave-function- and energy-functional-based methods. In particular, we point to
difficulties to formulate the restoration of symmetries within the energy
functional framework. The problems tackled recently in connection with
particle-number restoration serve as a baseline to the present discussion.
Reaching out to angular-momentum restoration, we identify an exact mathematical
property of the energy density that could be used to
constrain energy density functional kernels. Consequently, we suggest possible
routes towards a better formulation of symmetry restorations within energy
density functional methods.Comment: 16 pages, 3 figures, contribution to the "Focus issue on Open
Problems in Nuclear Structure", Journal of Physics
Low-lying quadrupole collective states of the light and medium Xenon isotopes
Collective low lying levels of light and medium Xenon isotopes are deduced
from the Generalized Bohr Hamiltonian (GBH). The microscopic seven functions
entering into the GBH are built from a deformed mean field of the Woods-Saxon
type. Theoretical spectra are found to be close to the ones of the experimental
data taking into account that the calculations are completely microscopic, that
is to say, without any fitting of parameters.Comment: 8 pages, 4 figures, 1 tabl
Cell cycle and aging, morphogenesis, and response to stimuli genes are individualized biomarkers of glioblastoma progression and survival
<p>Abstract</p> <p>Background</p> <p>Glioblastoma is a complex multifactorial disorder that has swift and devastating consequences. Few genes have been consistently identified as prognostic biomarkers of glioblastoma survival. The goal of this study was to identify general and clinical-dependent biomarker genes and biological processes of three complementary events: lifetime, overall and progression-free glioblastoma survival.</p> <p>Methods</p> <p>A novel analytical strategy was developed to identify general associations between the biomarkers and glioblastoma, and associations that depend on cohort groups, such as race, gender, and therapy. Gene network inference, cross-validation and functional analyses further supported the identified biomarkers.</p> <p>Results</p> <p>A total of 61, 47 and 60 gene expression profiles were significantly associated with lifetime, overall, and progression-free survival, respectively. The vast majority of these genes have been previously reported to be associated with glioblastoma (35, 24, and 35 genes, respectively) or with other cancers (10, 19, and 15 genes, respectively) and the rest (16, 4, and 10 genes, respectively) are novel associations. <it>Pik3r1</it>, <it>E2f3, Akr1c3</it>, <it>Csf1</it>, <it>Jag2</it>, <it>Plcg1</it>, <it>Rpl37a</it>, <it>Sod2</it>, <it>Topors</it>, <it>Hras</it>, <it>Mdm2, Camk2g</it>, <it>Fstl1</it>, <it>Il13ra1</it>, <it>Mtap </it>and <it>Tp53 </it>were associated with multiple survival events.</p> <p>Most genes (from 90 to 96%) were associated with survival in a general or cohort-independent manner and thus the same trend is observed across all clinical levels studied. The most extreme associations between profiles and survival were observed for <it>Syne1</it>, <it>Pdcd4</it>, <it>Ighg1</it>, <it>Tgfa</it>, <it>Pla2g7</it>, and <it>Paics</it>. Several genes were found to have a cohort-dependent association with survival and these associations are the basis for individualized prognostic and gene-based therapies. <it>C2</it>, <it>Egfr</it>, <it>Prkcb</it>, <it>Igf2bp3</it>, and <it>Gdf10 </it>had gender-dependent associations; <it>Sox10</it>, <it>Rps20</it>, <it>Rab31</it>, and <it>Vav3 </it>had race-dependent associations; <it>Chi3l1</it>, <it>Prkcb</it>, <it>Polr2d</it>, and <it>Apool </it>had therapy-dependent associations. Biological processes associated glioblastoma survival included morphogenesis, cell cycle, aging, response to stimuli, and programmed cell death.</p> <p>Conclusions</p> <p>Known biomarkers of glioblastoma survival were confirmed, and new general and clinical-dependent gene profiles were uncovered. The comparison of biomarkers across glioblastoma phases and functional analyses offered insights into the role of genes. These findings support the development of more accurate and personalized prognostic tools and gene-based therapies that improve the survival and quality of life of individuals afflicted by glioblastoma multiforme.</p
Life-Cycle and Genome of OtV5, a Large DNA Virus of the Pelagic Marine Unicellular Green Alga Ostreococcus tauri
Large DNA viruses are ubiquitous, infecting diverse organisms ranging from algae to man, and have probably evolved from an ancient common ancestor. In aquatic environments, such algal viruses control blooms and shape the evolution of biodiversity in phytoplankton, but little is known about their biological functions. We show that Ostreococcus tauri, the smallest known marine photosynthetic eukaryote, whose genome is completely characterized, is a host for large DNA viruses, and present an analysis of the life-cycle and 186,234 bp long linear genome of OtV5. OtV5 is a lytic phycodnavirus which unexpectedly does not degrade its host chromosomes before the host cell bursts. Analysis of its complete genome sequence confirmed that it lacks expected site-specific endonucleases, and revealed the presence of 16 genes whose predicted functions are novel to this group of viruses. OtV5 carries at least one predicted gene whose protein closely resembles its host counterpart and several other host-like sequences, suggesting that horizontal gene transfers between host and viral genomes may occur frequently on an evolutionary scale. Fifty seven percent of the 268 predicted proteins present no similarities with any known protein in Genbank, underlining the wealth of undiscovered biological diversity present in oceanic viruses, which are estimated to harbour 200Mt of carbon