Tear biomarkers for keratoconus

Keratoconus is a progressive corneal thinning, ectatic condition, which affects vision. Recent advances in corneal topography measurements has helped advance proper diagnosis of this condition and increased research and clinical interests in the disease etiopathogenesis. Considerable progress has been achieved in understanding the progression of the disease and tear fluid has played a major role in the progress. This review discusses the importance of tear fluid as a source of biomarker for keratoconus and how advances in technology have helped map the complexity of tears and thereby molecular readouts of the disease. Expanding knowledge of the tear proteome, lipidome and metabolome opened up new avenues to study keratoconus and to identify probable prognostic or diagnostic biomarkers for the disease. A multidimensional approach of analyzing tear fluid of patients layering on proteomics, lipidomics and metabolomics is necessary in effectively decoding keratoconus and thereby identifying targets for its treatment

Sustaining private eye care practices during initial days of the coronavirus pandemic

Background: The coronavirus disease 2019 (COVID-19) pandemic created new challenges for private eye care practices. Safety issues were encountered by both the healthcare workers and patients. This short communication addresses the changes made in our private eye care practice during the pandemic and the valuable lessons learned for the future. Methods: We describe the challenges faced at our tertiary private eye care practice in India with respect to treating patients and preventing the transmission of COVID-19, considering the economic hardship within this area. We discuss the emerging economic, medical, legal, educational, and psychological issues and their solutions, which eye care hospitals could follow in the future to ensure safety without compromising quality of care. Results: Eye hospitals required efficient operation with reduced fixed expenses. Clinical practices were followed in the hospital as per the recommendations of the country’s apex ophthalmic body. Proper triage and prescreening of patients at the entrance, digitalization, teleophthalmology, staggered appointments, and role-appropriate personal protective equipment were important preventive measures. The operating room protocols were modified to ensure the safety of the operating staff. Special consent was obtained from patients to safeguard against legal repercussions arising from the pandemic. The training of residents and fellows led to new avenues, including the use of digital tools. Hospitals attempted to provide counseling and psychological support to their doctors and staff during these trying times. Conclusions: The COVID-19 pandemic will not be the last pandemic to occur in an ever-changing world. This event provided us with many new insights into the economic, clinical, legal, and psychological challenges of the COVID-19 pandemic and with ways to overcome these challenges and emerge intact. Clinical and surgical training suffered during the pandemic; however, the impact was only temporary. Clinical research gained respect because of the efforts undertaken during the pandemic. The pandemic was exceptionally harsh on many private eye care practices, and we hope to provide useful and comprehensive solutions on how to successfully navigate a similar situation if encountered in the future

Genie: A Generator of Natural Language Semantic Parsers for Virtual Assistant Commands

To understand diverse natural language commands, virtual assistants today are trained with numerous labor-intensive, manually annotated sentences. This paper presents a methodology and the Genie toolkit that can handle new compound commands with significantly less manual effort. We advocate formalizing the capability of virtual assistants with a Virtual Assistant Programming Language (VAPL) and using a neural semantic parser to translate natural language into VAPL code. Genie needs only a small realistic set of input sentences for validating the neural model. Developers write templates to synthesize data; Genie uses crowdsourced paraphrases and data augmentation, along with the synthesized data, to train a semantic parser. We also propose design principles that make VAPL languages amenable to natural language translation. We apply these principles to revise ThingTalk, the language used by the Almond virtual assistant. We use Genie to build the first semantic parser that can support compound virtual assistants commands with unquoted free-form parameters. Genie achieves a 62% accuracy on realistic user inputs. We demonstrate Genie's generality by showing a 19% and 31% improvement over the previous state of the art on a music skill, aggregate functions, and access control.Comment: To appear in PLDI 201

Agriculture, nutrition and gender in India

The South Asian region has one of the highest rates of child and maternal undernutrition in the world. Undernutrition is widespread and persistent even in India despite its relatively strong economic performance and is particularly high in rural areas and among those in agriculture based livelihoods. Though agriculture has the enormous potential to contribute to improvements in undernutrition, the evidence so far in the Indian context demonstrates weak linkages between agriculture and nutrition . This research brief summarises the key findings from the different studies focusing on women’s agency and nutrition undertaken by LANSA in India.Department for International Development (DFID)UKAI

Agriculture-nutrition linkages and child undernutrition in India

The South Asian region and in particular India, has one of the highest rates of child undernutrition in the world, and is home to around 40 per cent of the global total of children who are stunted. Child stunting has been shown to have severe lifelong economic, health, and cognitive disadvantages and costs. Despite improvements in some states in recent years, the levels continue to be high. Understanding the reasons for the high prevalence of child undernutrition in India in the face of the relatively strong economic performance has emerged as an important research topic and is an area of focus of LANSA’s research in the region. Under the research theme, ‘How enabling is the wider context in linking agriculture and food systems to other determinants of nutritional status?’, LANSA research in India focuses on understanding the barriers and facilitators to nutrition-sensitive agricultural development in the country. The analyses and empirical work on the available large secondary datasets from India are expected to elaborate on the pathways that connect agriculture and nutrition and the type and degree of interaction with other non-food drivers. This research brief summarises the key findings from some of the studies undertaken by LANSA partners, on agriculture-nutrition linkages and child undernutrition in India.Department for International Development (DFID)UKAI

Prosthesis for a Case of Subtotal Orbital Exenteration

Aims and objectives: To rehabilitate a patient with subtotal orbital exenteration defect. Case description: A 32 year old male with history of carcinoma of ethmoid, treated surgically with subtotal orbital exenteration presented with a defect communicating with the pharynx. He was rehabilitated with a prosthetic eye. Conclusion: A two piece cast with a removable part containing the defect made it very easy to fabricate the prosthesis. Patient was happy with the appearance and expressed satisfaction.&nbsp

Importance of WASH and Healthcare for enabling Agriculture-Nutrition linkages in India

State and district level studies linking child undernutrition to agricultural prosperity and provisioning of public services highlight the importance of public health provisioning such as sanitation, vaccination and healthcare facilities in rural areas, public provisioning for maternal health and women’s education as well as social provisioning of food. This policy brief discusses the following focus polices and programmes: National Health Mission; Swachh Bharat Abhiyan 2014; Draft National Policy for Women 2016; Draft National Plan of Action for Children 2016; National Food Security Act 2013; National Policy for Empowerment of Women 2001.Department for International Development (DFID)UKAI

Women in Agriculture and Nutrition in India

Policy debates around agriculture and nutrition and the crucial role of women needs to be informed by evidence that research programmes like LANSA generate. The available evidence recommends the recognition of women’s roles in agriculture and nutrition. This Policy Brief looks at the following focus polices and programmes: Draft National Policy for Women 2016; National Policy for Empowerment of Women 2001; Supplementary Nutrition Programme under ICDS; National Nutrition Policy 1993; National Food Security Act 2013; National Policy for Farmers 2007.Department for International Development (DFID)UKAI

Development of Foetal Body Parts as per Garbhaavakraanti Shaareera - An Ayurvedic Perspective

The conception and development of a healthy offspring have been a paramount concern for humanity throughout history. This concern is deeply rooted in various cultures and traditions, and Ayurveda, an ancient Indian system of medicine, offers a holistic perspective on factors that influence the growth and development of a fetus. Ayurveda underscores several critical factors to ensure the birth of a normal and healthy progeny. These factors include "Garbha Saamagri," which pertains to the quality of reproductive materials, emphasizing the significance of the parents' health at the time of conception. "Daurhruda" relates to the timing and season of conception, asserting that environmental factors play a role in the child's health. The "Pitrujadi Six Factors" encompass inherited attributes from both parents, stressing the importance of genetic compatibility between partners. Additionally, Ayurveda places a strong emphasis on the lifestyle and nutrition of the pregnant woman, her emotional well-being, and the regimen during her menstrual cycle. All these factors are believed to influence the child's constitution and overall health. "Svabhava" considers the inherent nature and constitution of both parents, which can affect the physical and mental attributes of the child. It is important to note that Ayurveda offers a holistic and ancient perspective on these factors. In conclusion, Ayurveda provides a comprehensive framework for understanding the factors that influence fetal growth and development

Multi-color imaging in a unilateral central retinal artery occlusion following dengue fever: A case report and literature review

Background: Dengue fever is associated with various sight-threatening ocular manifestations, some of which can occur several months after fever. These include subconjunctival hemorrhage, vitreous hemorrhage, retinal hemorrhage, cotton wool spots, central and branch retinal artery occlusion, central scotoma, papilledema, optic neuropathy, retinal vasculitis, retinitis, retinal pigment epithelium mottling, foveolitis, choroidal effusion, exudative retinal detachment, anterior uveitis, endogenous endophthalmitis, and panophthalmitis. Herein, we report a patient with unilateral central retinal artery occlusion (CRAO) and raised dengue immunoglobulin G (IgG) titers who underwent serial multimodal imaging with fundus photography, spectral domain optical coherence tomography (SD-OCT), optical coherence tomography angiography (OCTA), and multi-color imaging (MCI). Furthermore, we reviewed recent publications highlighting different eye diseases and the role of MCI in their diagnosis and serial monitoring. Case presentation: A 53-year-old Asian Indian woman complained of blurring of vision in the right eye (OD) two months after a bout of fever. Her best-corrected distance visual acuity was finger counting close to the face in the OD and 20/40 in the left eye. CRAO of the OD was diagnosed. Systemic investigations were normal except for elevated dengue IgG levels. Optical coherence tomography and fluorescein angiography confirmed this diagnosis. MCI and SD-OCT using Spectralis™ performed before and after treatment with oral steroids demonstrated improvement. MCI served as a noninvasive ancillary tool for monitoring the CRAO. In addition to the case report, we summarize articles pertaining to MCI published during the years 2018–2022. The list is not exhaustive but highlights salient features of different retinal and choroidal disorders evaluated using MCI. Our summary highlights the role of MCI in the diagnosis and serial monitoring of eye diseases. Conclusions: A diagnosis of post-dengue fever retinal artery occlusion should be made after ruling out other causes of retinal artery vascular occlusion. We demonstrated retinal changes using serial imaging. MCI can be a useful tool, along with SD-OCT, to monitor clinical improvement. Optometrists can follow up patients with retinal vascular occlusions using noninvasive methods