Study of properties of Aegle Marmelos Reinforced Composite Fiber

Natural particulate and natural fibre composites have attracted substantial importance as a potential structural material. Different types of composite have different characteristics depends up on their composition. The fundamental properties of composite material is that they are cheap and eco friendly. Composites are low cost light in weight, biodegradable and renewable and completely or partially recyclable. Due to these attractive properties of the composite material there is a need to further explore the possibility of new natural particulate to be used as reinforcement in polymer composites. In this paper, Aegle Marmelos (locally known as Bel) is taken as natural fiber for analyzing. This paper mainly concentrates on made to prepare and study the mechanical and environmental behaviour of Aegle Marmelos Reinforced Composite Fiber. This paper also focuses on evaluation of the mechanical properties like impact strength of Aegle Marmelos fiber composites using different tests

Salvaging collateral damage by COVID-19 pandemic in form of exposed silicone ear framework in 33-year post reconstructed ear

Total ear reconstruction is being practiced by different techniques. Ready to use Silicone ear framework (Silastic ear framework by Dow corning) was being used frequently by Plastic surgeons in the eighties and nineties of the twentieth century. Framework exposure, either due to skin necrosis or due to infection used to be the commonest complication in the early postoperative period. A follow-up case of a 50 year old male patient, our 33 years follow up case of Total ear reconstruction by silicone ear framework implantation presented to us with exposed silicone framework and infection. Due to constant use of facemask with elastic ear loop for support during COVID-19 pandemic. The exposed infected implant successfully salvaged using negative pressure wound therapy. In all cases of autologous or alloplastic ear reconstruction, we strictly recommend not to use facemasks with elastic ear loops. If a facemask has to be used it should have a head loop or to be used with an ear protector. 

In-Vitro Evidences for the Formulation, Development, and Evaluation of Budesonide Oral Nano-sponges

Idiopathic inflammatory bowel disease is quite common, with ulcerative colitis and Crohn's disease being the most common forms. Due to its high receptor affinity and quick diversion, the anti-inflammatory effects of the glucocorticoid budesonide are limited, but it is nevertheless useful in some situations. A unique BUD nano-sponges was developed by employing quasi-solvent diffusion and Eudragit S-100 as the polymer to address the problem of low efficacy and accessibility. Material and Methods: Drug release profile and percentage of drug entrapment in BUD Nano sponges were also measured and analyzed. Clinical activity score, colon/body weight ratio, and macroscopic ulceration activity were among the criteria used in an in vivo investigation of the formulation in male Wistar rats. Finally, histological investigation was done on colon tissue samples. Results: When compared to other BUD formulations on the market, this one performed exceptionally well, suggesting that the designed nanosponges are highly effective. The Wistar rats' clinical activity score was reduced when treated with the formed nanosponges. When compared to the placebo group, those who took this supplement saw a dramatic decrease in their colon weight ratio. Nanosponge colon histology revealed healthy colon anatomy and architecture. Conclusion: The findings of this study have substantiated the efficacy of BUD nano-sponges as innovative carriers in the treatment of inflammatory bowel diseas

In Vitro Evaluation of Antioxidant, Anticancer, and Anti-Inflammatory Activities of Ethanolic Leaf Extract of Adenium obesum

Adenium obesum commonly known as “desert rose” belongs to the family Apopcynaceae and has previously been reported for its anti-influenza, antimicrobial, and cytotoxic efficacies and well-known for their ethno-medicinal applications. In the present study, ethanolic extracts of A. obesum (AOE) were analyzed by gas chromatography-mass spectrometry (GC–MS) to identify the important phytochemical compounds. The GC–MS analysis of AOE detected the presence of 26 phytochemical compounds. This plant is traditionally used for the treatment of various diseases. In this report, the antioxidant, anti-inflammatory, and anticancer activities of ethanolic leaf extract from A. obesum (AOE) were studied. The antioxidant potential of ethanolic extract of AOE was examined by different antioxidant assays, such as antioxidant capacity by the DPPH, ABTS, superoxide, hydroxyl radical scavenging, and lipid peroxidation inhibition assays. The antioxidant activities of various reaction mixtures of AOE were compared with a reference or standard antioxidant (ascorbic acid). In addition, we also evaluated the anticancer activity of AOE, and it was observed that AOE was found to be cytotoxic against A549 lung cancer cells. It was found that AOE inhibited the viability of A549 lung cancer cells by inducing nuclear condensation and fragmentation. Furthermore, ethanolic AOE demonstrated the anti-inflammatory potential of AOE in murine alveolar macrophages (J774A.1) as an in vitro model system. AOE showed its potential in reducing the levels of inflammatory mediators including the proinflammatory cytokines and TNF-α. The results obtained in the present investigation established the antioxidant, anticancer, and anti-inflammatory potency of AOE, which may account for subsequent studies in the formulation of herbal-based medicine

Targeting NF-κB signaling cascades of glioblastoma by a natural benzophenone, garcinol, via in vitro and molecular docking approaches

Glioblastoma multiforme (GBM) is regarded as the most aggressive form of brain tumor delineated by high cellular heterogeneity; it is resistant to conventional therapeutic regimens. In this study, the anti-cancer potential of garcinol, a naturally derived benzophenone, was assessed against GBM. During the analysis, we observed a reduction in the viability of rat glioblastoma C6 cells at a concentration of 30 µM of the extract (p < 0.001). Exposure to garcinol also induced nuclear fragmentation and condensation, as evidenced by DAPI-stained photomicrographs of C6 cells. The dissipation of mitochondrial membrane potential in a dose-dependent fashion was linked to the activation of caspases. Furthermore, it was observed that garcinol mediated the inhibition of NF-κB (p < 0.001) and decreased the expression of genes associated with cell survival (Bcl-XL, Bcl-2, and survivin) and proliferation (cyclin D1). Moreover, garcinol showed interaction with NF-κB through some important amino acid residues, such as Pro275, Trp258, Glu225, and Gly259 during molecular docking analysis. Comparative analysis with positive control (temozolomide) was also performed. We found that garcinol induced apoptotic cell death via inhibiting NF-κB activity in C6 cells, thus implicating it as a plausible therapeutic agent for GBM

Climate Change and COP26: Are Digital Technologies and Information Management Part of the Problem or the Solution? An Editorial Reflection and Call to Action

The UN COP26 2021 conference on climate change offers the chance for world leaders to take action and make urgent and meaningful commitments to reducing emissions and limit global temperatures to 1.5 °C above pre-industrial levels by 2050. Whilst the political aspects and subsequent ramifications of these fundamental and critical decisions cannot be underestimated, there exists a technical perspective where digital and IS technology has a role to play in the monitoring of potential solutions, but also an integral element of climate change solutions. We explore these aspects in this editorial article, offering a comprehensive opinion based insight to a multitude of diverse viewpoints that look at the many challenges through a technology lens. It is widely recognized that technology in all its forms, is an important and integral element of the solution, but industry and wider society also view technology as being part of the problem. Increasingly, researchers are referencing the importance of responsible digitalization to eliminate the significant levels of e-waste. The reality is that technology is an integral component of the global efforts to get to net zero, however, its adoption requires pragmatic tradeoffs as we transition from current behaviors to a more climate friendly society

Climate change and COP26: Are digital technologies and information management part of the problem or the solution? An editorial reflection and call to action

The UN COP26 2021 conference on climate change offers the chance for world leaders to take action and make urgent and meaningful commitments to reducing emissions and limit global temperatures to 1.5 °C above pre-industrial levels by 2050. Whilst the political aspects and subsequent ramifications of these fundamental and critical decisions cannot be underestimated, there exists a technical perspective where digital and IS technology has a role to play in the monitoring of potential solutions, but also an integral element of climate change solutions. We explore these aspects in this editorial article, offering a comprehensive opinion based insight to a multitude of diverse viewpoints that look at the many challenges through a technology lens. It is widely recognized that technology in all its forms, is an important and integral element of the solution, but industry and wider society also view technology as being part of the problem. Increasingly, researchers are referencing the importance of responsible digitalization to eliminate the significant levels of e-waste. The reality is that technology is an integral component of the global efforts to get to net zero, however, its adoption requires pragmatic tradeoffs as we transition from current behaviors to a more climate friendly society.</p

Mass-Spectroscopy of hidden charm and hidden strange tetraquarks in diquark-antidiquark approach

We investigated the four-quark systems with quark structures of $cs\bar{c}\bar{s}$, $cq\bar{c}\bar{s}$, $bs\bar{b}\bar{s}$, and $bq\bar{b}\bar{s}$ in the framework of the non-relativistic quark model, motivated by the recent observation of exotic resonances X(4140), X(4274), X(4350), X(4500), and X(4700) reported by several experiment collaborations. The colour antitriplet-triplet configuration of diquark-antidiquark combinations with all conceivable quantum numbers have been used to calculate their masses. The results reveal that if the colour structure of the diquark-antidiquark configuration is $\bar{3}_{c} \otimes 3$, the tetraquarks structures may occur otherwise may observed as resonance. The X(4274) state, can be defined as the $J^{PC}$=$2^{++}$ tetraquark state, while the X(4140) state can be regarded as the $J^{PC}$=$1^{++}$ tetraquark state in this calculation. When radial excitation is considered, X(4700) may be explained as a 2S radial excited tetraquark state with $J^{PC}$=$0^{++}$. The orbitally excited states Y(4626), Y(4630) and Y(4660) can be explained as P-wave tetraquark with quantum number $1^{--}$. The masses of [$bs\bar{b}\bar{s}$] and [$bq\bar{b}\bar{s}$] are found to be in the range between 10.5 GeV- 11.5 GeV and are very close to two-meson thresholds.Comment: 13 Pages. arXiv admin note: text overlap with arXiv:2205.00679. text overlap with arXiv:2108.0652

Impact of COVID-19 on logistics systems and disruptions in food supply chain

An outbreak of deadly COVID-19 virus has not only taken the lives of people but also severely crippled the economy. Due to strict lockdown, the manufacturing and logistics activities have been suspended, and it has affected the demand and supply of various products as a result of restrictions imposed on shopkeepers and retailers. Impacts of COVID-19 are observed ubiquitously in every type of units from different sectors. In this study, a simulation model of the public distribution system (PDS) network is developed with three different scenarios to demonstrate disruptions in the food supply chain. Difficulties have been increased in matching supply and demand in a vast network of PDS because of changing scenarios with the growth of infected cases and recovery. This paper also highlights the importance of a resilient supply chain during a pandemic. Our proposed simulation model can help in developing a resilient and responsive food supply chain to match the varying demand, and then further assist in providing decision-making support for rerouting the vehicles as per travel restrictions in areas. Paper has been summarised with significant highlights and including future research scope for developing a more robust food supply chain network