Radioactive Iodine Therapy and Glucose Tolerance

Radioactive iodine therapy is commonly used as an adjuvant therapy in follicular and papillary thyroid carcinoma (PTC) and in the treatment of Graves’ disease (GD). The basis of this therapy is the accumulation of radioactive iodine by the sodium-iodide symporter (NIS) in the thyroid gland. Expression of NIS by extrathyroidal tissues such as islets of pancreas has been reported. Radioactive iodine uptake by pancreatic beta-cells can potentially damage these cells. In this study, we discuss the possible associations between radioactive iodine and glucose intolerance. Overall, radioactive iodine uptake by the pancreas may damage beta-cells and predispose patients to glucose intolerance or type 2 diabetes, particularly in patients exposed to radioactive iodine therapy following total thyroidectomy. Further studies are needed to clarify and confirm this association

Assessment of the safety of chicken egg yolk antibody (IgY) consumption by lipid peroxidation marker in mice

Production of antibodies in chickens (IgY) has significantly attracted attention of scientists. Numerous publications have reported use of IgY in diagnosis, therapy and prophylaxis. Production of antigen-specific antibodies in chicken can help treat and prevent infectious diseases. The aim of this study was to assess the safety  of IgY( anti  E. coli O157:H7)  on the antioxidant system in mice .Therefore in  this study, three different  doses of IgY against E. coli O157:H7 (0.9375, 1.875 and  3.75 g / kg)  were administrated through oral route to 18 mice (treated groups) and PBS to the control group  and 14 days after administration, blood samples were collected from the mice. Serum malondialdehyde (MDA) level and catalase, glutathione peroxidase and superoxide dismutase activity were measured using commercial kits. Oral administration of IgY against E. coli O157:H7 in  doses  of 0.9375, 1.875 and 3.75 g / kg  caused no  deaths and showed no toxic effects on mice. In this study, after 14 days of  IgY administration there were no significant changes in the activity of antioxidant enzymes (catalase, glutathione peroxidase and superoxide dismutase) and  MDA  serum level   compared to the control group. Our findings revealed that oral administration of IgY against E. coli O157:H7 does not show any toxic effects and does not   disturb the antioxidant system in mice . These findings could be indicative of safety of oral administration  of  IgY in mice