Additional file 1: of Electroacupuncture for tapering off long-term benzodiazepine use: study protocol of randomized controlled trial

The Standardized Operating Procedure (SOP) of Electroacupuncture Treatment. (DOCX 18 kb

Multivariate associations between clinical outcomes and antipsychotic medication modes in patients with schizophrenia who were treated concomitantly with CM.^a

<p>a. CM, Chinese medicine. Unchanged outcomes (n = 213) served as reference. Multinomial logistical regression analysis was adjusted for resident areas, diagnostic subtype, and duration of CM use, variables significantly associated with clinical outcomes as shown in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0017239#pone-0017239-t003" target="_blank">Table 3</a>.</p><p>b. It is noted that all quetiapine-including treatment regimens are quetiapine monotherapy.</p

Bivariate and multivariate associations between clinical outcomes and CM use in patients with schizophrenia.^a

<p>a. CM, Chinese medicine. Data analyses were based on CM users (n = 671) with non-CM users (n = 1117) as reference. Chi-square test was used for bivariate analysis and binary logistic regression for multivariate analysis.</p><p>b. Binary logistic regression analysis was adjusted for sex, resident areas, household income, duration of illness, number of episode, and number of hospitalization, variables significantly associated with CM use as shown in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0017239#pone-0017239-t001" target="_blank">Table 1</a>.</p

Changes in score on depression scales from baseline in MDD patients.

a<p>Overall and between-group <i>P</i> values were obtained from linear mixed-effects model analysis and student <i>t</i>-test, respectively.</p><p>MDD, major depressive disorder; n-EA, noninvasive electroacupuncture; DCEAS, dense cranial electroacupuncture stimulation; 95% CI, 95% confidence interval; HAMD-17, 17-item Hamilton Rating Scale for Depression; CGI-S, Clinical Global Impression-Severity; SDS, Self-rating Depression Scale.</p

Mean changes from baseline in score on the 17-item Hamilton Rating Scale for Depression (HAMD-17), Clinical Global Impression-Severity (CGI-S) and Self-rating Depression Scale (SDS).

<p>Data are expressed as mean with 95% confidence interval (95% CI). * <i>P</i>≤0.037: between-group comparison using Student <i>t</i>-test.</p

Adverse events occurred in at least 5% of patients in either group.

a<p><i>P</i> values were calculated from Fisher Exact test.</p><p>n-EA, noninvasive electroacupuncture; DCEAS, dense cranial electroacupuncture stimulation.</p

Acupoints used in dense cranial electroacupuncture stimulation (DCEAS).

<p>Acupoints used in dense cranial electroacupuncture stimulation (DCEAS).</p