Additional file 1: Table S1. of Estimates of hospitalization attributable to influenza and RSV in the US during 1997–2009, by age and risk status

Seasonal burden of hospitalization attributable to influenza and RSV by season in the US, 1997–2009 (respiratory broad outcome, any mention). 1Annual mean rate per 100,000 population; *Data included up to 31st March 2009; CI: confidential interval. Table S2. Number of hospitalizations attributable to influenza and RSV according to risk status and age in the US, 1997–2009 (respiratory broad outcome, any mention). SD: standard deviation; RSV: respiratory syncytial virus. (DOCX 42 kb

Additional file 1: Table S1. of Modelling estimates of age-specific influenza-related hospitalisation and mortality in the United Kingdom

Outcomes: hospitalisations (HES) and deaths (ONS). Table S2. Definition of risk factors; any mention of any of these codes placed the patient in the “high-risk” category. Table S3. Mean number of other hospitalisations due to non-respiratory diagnoses attributable to influenza in the United Kingdom. Table S4. Mean number of deaths due to respiratory diagnoses attributable to influenza in the United Kingdom. (DOCX 85 kb

Pandemic respiratory mortality rates projected to all world countries with the Stage 2 multiple imputation model, stratified by age.

<p>(A) Under 65 y and (B) all ages. Numbers in map legend are pandemic mortality rates per 100,000 persons.</p

Additional file 1: of Modelling estimates of the burden of Respiratory Syncytial virus infection in adults and the elderly in the United Kingdom

CPRD Coding Definitions. (DOCX 512 kb

Sensitivity analysis of global and regional pandemic respiratory mortality rates.

<p>The Stage 2 model was run multiple times, each time removing one Stage 1 country, for (A) all ages and (B) <65 y. The global estimates (black diamonds) were relatively stable, but some regions were sensitive to the removal of individual countries. <a href="http://www.plosmedicine.org/article/info:doi/10.1371/journal.pmed.1001558#pmed.1001558.s001" target="_blank">Figure S1</a> depicts the corresponding sensitivity analysis results for seasonal estimates. Eastern Med, Eastern Mediterranean; SEAR, South-East Asia; Western Pac, Western Pacific.</p

Pandemic excess mortality estimates for Stage 1 countries, by age and outcome (respiratory, cardiorespiratory, and all cause).

<p>Data are grouped into four geographical regions.</p

Stage 1 customizations and all-ages model fit for 20 GLaMOR participating countries.

a<p>Europe experienced severe heat waves in 2003 and 2006; hence, summer weeks with elevated mortality were excluded.</p><p>NA, not available.</p

Output of the data creation phase for multiple imputation and matching for one randomly selected country per region.

<p>Eastern Med, Eastern Mediterranean; Imp, multiple imputation method; Match, matching method.</p

Examples of regional heterogeneity in pandemic mortality impact: Mexico (high burden) and France (low burden).

<p>In Mexico, a substantial H1N1pdm09 respiratory mortality burden (red areas above gray background mortality) occurred among children, young adults, and middle-aged persons (<65 y) of age but not among seniors (≥65 y). In France, however, there was a far less dramatic pandemic impact that, despite the similar population size, was captured only in the <65-y age group model. Seasonal influenza burden (blue areas) was also generated by the Stage 1 model. The vertical black line represents the start of the pandemic.</p

Comparison of GLaMOR mortality estimates to those of Dawood et al.

<p>GLaMOR all-age respiratory mortality estimated directly from all-age multiple imputation (open circles) and by proportional extrapolation of the <65-y age group estimate to all ages using the age distribution of laboratory-confirmed mortality surveillance (black circles), compared to estimates by Dawood et al. <a href="http://www.plosmedicine.org/article/info:doi/10.1371/journal.pmed.1001558#pmed.1001558-Dawood1" target="_blank">[19]</a> (black plus signs). Eastern Med, Eastern Mediterranean.</p