20 research outputs found
Biologically active guanidine alkaloids from the Mediterranean sponge Crambe crambe
The isolation and structure detn. of four new toxic guanidine alkaloids from the sponge C. crambe are described. Crambine A, B and C1 were isolated from C. crambe collected near Banyuls (France) while crambine C2, closely related to crambine C1, was isolated from C. crambe collected off Favignana (Italy). A hypothetical biosynthetic pathway of the crambines is proposed. Pure crambines A, B and C1 were ichthyotoxic for the fish Lebistes reticulatus
Crambines C1 and C2: two further ichthyotoxic guanidine alkaloids from the sponge Crambe crambe
Crambines C1 (I, n = 4) and C2 (I, n = 3) are two new ichthyotoxic guanidine alkaloids isolated from the Mediterranean sponge Crambe crambe. Their structures were detd. on the basis of their spectral properties. Biogenetically they are closely related to crambines A and B, which was isolated previously from the same sponge