17 research outputs found
Regulation in speech motor control in ET patients treated with DBS: Kinematics of the lingual and the labial systems
The effects of Thalamic Deep Brain Stimulation on speech dynamics in patients with Essential Tremor: An articulographic study
<div><p>Acoustic studies have revealed that patients with Essential Tremor treated with thalamic Deep Brain Stimulation (DBS) may suffer from speech deterioration in terms of imprecise oral articulation and reduced voicing control. Based on the acoustic signal one cannot infer, however, whether this deterioration is due to a general slowing down of the speech motor system (e.g., a target undershoot of a desired articulatory goal resulting from being too slow) or disturbed coordination (e.g., a target undershoot caused by problems with the relative phasing of articulatory movements). To elucidate this issue further, we here investigated both acoustics and articulatory patterns of the labial and lingual system using Electromagnetic Articulography (EMA) in twelve Essential Tremor patients treated with thalamic DBS and twelve age- and sex-matched controls. By comparing patients with activated (DBS-ON) and inactivated stimulation (DBS-OFF) with control speakers, we show that critical changes in speech dynamics occur on two levels: With inactivated stimulation (DBS-OFF), patients showed coordination problems of the labial and lingual system in terms of articulatory imprecision and slowness. These effects of articulatory discoordination worsened under activated stimulation, accompanied by an additional overall slowing down of the speech motor system. This leads to a poor performance of syllables on the acoustic surface, reflecting an aggravation either of pre-existing cerebellar deficits and/or the affection of the upper motor fibers of the internal capsule.</p></div
The effects of Thalamic Deep Brain Stimulation on speech dynamics in patients with Essential Tremor: An articulographic study
<div><p>Acoustic studies have revealed that patients with Essential Tremor treated with thalamic Deep Brain Stimulation (DBS) may suffer from speech deterioration in terms of imprecise oral articulation and reduced voicing control. Based on the acoustic signal one cannot infer, however, whether this deterioration is due to a general slowing down of the speech motor system (e.g., a target undershoot of a desired articulatory goal resulting from being too slow) or disturbed coordination (e.g., a target undershoot caused by problems with the relative phasing of articulatory movements). To elucidate this issue further, we here investigated both acoustics and articulatory patterns of the labial and lingual system using Electromagnetic Articulography (EMA) in twelve Essential Tremor patients treated with thalamic DBS and twelve age- and sex-matched controls. By comparing patients with activated (DBS-ON) and inactivated stimulation (DBS-OFF) with control speakers, we show that critical changes in speech dynamics occur on two levels: With inactivated stimulation (DBS-OFF), patients showed coordination problems of the labial and lingual system in terms of articulatory imprecision and slowness. These effects of articulatory discoordination worsened under activated stimulation, accompanied by an additional overall slowing down of the speech motor system. This leads to a poor performance of syllables on the acoustic surface, reflecting an aggravation either of pre-existing cerebellar deficits and/or the affection of the upper motor fibers of the internal capsule.</p></div
Schematised modification of articulatory control parameters.
<p>Schematised modification of articulatory control parameters.</p
Projection of all active contacts (blue) onto a neuroanatomical atlas [19].
<p>Green: VIM, red: red nucleus. Note that most active contacts lay inside the VIM proper or at its ventral border while two contacts lay slightly more ventral in the zona incerta.</p
Modification of articulatory control parameters and related phonetic output.
<p>Modification of articulatory control parameters and related phonetic output.</p
Articulatory measurements (mean and SD) across subjects for control, DBS-OFF, and DBS-ON, sorted by POA.
<p>Articulatory measurements (mean and SD) across subjects for control, DBS-OFF, and DBS-ON, sorted by POA.</p
Acoustic waveform and spectrogram for /ta/ and corresponding tongue tip position (vertical and horizontal position with the same range across speakers) during the production of /t/, for one ET patient in the DBS-OFF (middle) and DBS-ON condition (right) and one age-matched control-speaker (left).
<p>Acoustic waveform and spectrogram for /ta/ and corresponding tongue tip position (vertical and horizontal position with the same range across speakers) during the production of /t/, for one ET patient in the DBS-OFF (middle) and DBS-ON condition (right) and one age-matched control-speaker (left).</p