185 research outputs found
The Synthesis and Isolation of Mono-BOC-Protected 1,4-Phenylene Diamine and Further Reaction with Hexamolybdate
Synthesis of Ξ±- and Ξ²-Carbolines by a Metalation/Negishi Cross- Coupling/SNAr Reaction Sequence
A methodology for the synthesis of Ξ±- and Ξ²-carbolines from fluoropyridines and 2-haloanilines is reported. This procedure consists of a four-step directed ortho-lithiation, zincation, Negishi cross-coupling, and intramolecular nucleophilic aromatic substitution, providing access to a diverse set of functionalized carbolines. While the procedure is applicable to batch conditions, the generation of arylzinc intermediates in continuous flow has been demonstrated
ΠΡΡΡΡΠΎΠ΄Π΅ΠΉΡΡΠ²ΡΡΡΠ°Ρ ΡΠΈΡΡΠ΅ΠΌΠ° ΡΡΠ°Π±ΠΈΠ»ΠΈΠ·Π°ΡΠΈΠΈ ΠΏΠ΅ΡΠ΅ΠΌΠ΅Π½Π½ΠΎΠ³ΠΎ Π½Π°ΠΏΡΡΠΆΠ΅Π½ΠΈΡ
Π Π°ΡΡΠΌΠ°ΡΡΠΈΠ²Π°Π΅ΡΡΡ ΡΠΈΡΡΠ΅ΠΌΠ° ΡΡΠ°Π±ΠΈΠ»ΠΈΠ·Π°ΡΠΈΠΈ ΠΏΠ΅ΡΠ΅ΠΌΠ΅Π½Π½ΠΎΠ³ΠΎ Π½Π°ΠΏΡΡΠΆΠ΅Π½ΠΈΡ Π½Π° ΠΎΡΠ½ΠΎΠ²Π΅ ΠΌΠ°Π³Π½ΠΈΡΠ½ΠΎ-ΠΏΠΎΠ»ΡΠΏΡΠΎΠ²ΠΎΠ΄Π½ΠΈΠΊΠΎΠ²ΠΎΠ³ΠΎ ΡΠ΅Π³ΡΠ»ΡΡΠΎΡΠ° Π±Π΅Π· ΠΏΠΎΠ΄ΠΌΠ°Π³Π½ΠΈΡΠΈΠ²Π°Π½ΠΈΡ ΠΏΠΎΡΡΠΎΡΠ½Π½ΡΠΌ ΡΠΎΠΊΠΎΠΌ ΠΈ Π±ΡΡΡΡΠΎΠ΄Π΅ΠΉΡΡΠ²ΡΡΡΠ΅ΠΉ ΠΎΠ±ΡΠ°ΡΠ½ΠΎΠΉ ΡΠ²ΡΠ·ΠΈ. ΠΠΎ ΠΎΠΏΠΈΡΠ°Π½Π½ΠΎΠΌΡ ΠΏΡΠΈΠ½ΡΠΈΠΏΡ ΠΌΠΎΠ³ΡΡ Π±ΡΡΡ ΠΏΠΎΡΡΡΠΎΠ΅Π½Ρ Π±ΡΡΡΡΠΎΠ΄Π΅ΠΉΡΡΠ²ΡΡΡΠΈΠ΅ ΠΎΠ΄Π½ΠΎΡΠ°Π·Π½ΡΠ΅ ΠΈ ΡΡΠ΅Ρ
ΡΠ°Π·Π½ΡΠ΅ ΡΡΠ°Π±ΠΈΠ»ΠΈΠ·Π°ΡΠΎΡΡ Π½Π°ΠΏΡΡΠΆΠ΅Π½ΠΈΡ Π½Π° Π²ΡΡΡΠ΅ΡΠ½ΠΎ-ΠΏΠ°ΡΠ°Π»Π»Π΅Π»ΡΠ½ΡΡ
ΡΠΏΡΠ°Π²Π»ΡΠ΅ΠΌΡΡ
Π²Π΅Π½ΡΠΈΠ»ΡΡ
ΠΏΡΠΈ ΠΈΡ
Π΅ΡΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎΠΉ ΠΈΠ»ΠΈ ΠΏΡΠΈΠ½ΡΠ΄ΠΈΡΠ΅Π»ΡΠ½ΠΎΠΉ ΠΊΠΎΠΌΠΌΡΡΠ°ΡΠΈΠΈ
Singing Actors and Dancing Singers
This article looks at two recent and widely recognized productions of Henry Purcell's Dido and Aeneas (by choreographer Sasha Waltz, Berlin 2005, and theatre director Sebastian NΓΌbling, Basel 2006) and discusses three main aspects: 1. Genre: coming from a Tanztheater (Waltz) and a Sprechtheater (NΓΌbling) background, each director renegotiates conventions of the operatic genre and consciously evades expectations in pursuit of a new and challenging experience for both the performers and their audience. 2. Physicality: both productions place the performers' bodies at the forefront of the mise-en-scne they remap the singing, dancing, acting body by questioning conventions and expectations commonly found in the production and reception process. 3. Adaptation: both productions take unconventional liberties by adapting in a domain where notions of Werktreue (fidelity to the original work or score) still reign. Adopting ideas from Nicholas Cook and Mikhail Bakhtin, I will argue that the conceptual, musical and theatrical implications of both productions indicate a renegotiation of the social and performative relevance of operatic performance
Continuous-Flow Synthesis of Biaryls by Negishi Cross-Coupling of Fluoro- and Trifluoromethyl-Substituted (Hetero)arenes
A continuous-flow method for the regioselective arylation of fluoroarenes and fluoropyridines has been developed. The telescoped procedure reported here consists of a three-step metalation, zincation, and Negishi cross-coupling sequence, providing efficient access to a variety of functionalized 2-fluorobiaryl products. Precise temperature control of the metalation step, made possible by continuous-flow technology, allowed for the efficient preparation of the arylated products in high yields and short residence times. Additionally, several examples of the regioselective arylation of benzotrifluoride derivatives are also provided
Short Enantioselective Total Synthesis of Tatanan A and 3-epi-Tatanan A Using Assembly-Line Synthesis
Short and highly stereoselective total syntheses of the sesquilignan natural product tatanan A and its C3 epimer are described. An assembly-line synthesis approach, using iterative lithiationβborylation reactions, was applied to install the three contiguous stereocenters with high enantio- and diastereoselectivity. One of the stereocenters was installed using a configurationally labile lithiated primary benzyl benzoate, resulting in high levels of substrate-controlled (undesired) diastereoselectivity. However, reversal of selectivity was achieved by using a novel diastereoselective Matteson homologation. Stereospecific alkynylation of a hindered secondary benzylic boronic ester enabled completion of the synthesis in a total of eight steps
Stereoselective synthesis of (R)- and (S)-1,2-diazetidine-3-carboxylic acid derivatives for peptidomimetics
The stereoselective synthesis of both enantiomers of N-protected 1,2-diazetidine-3-carboxylic acid (aAze) from homochiral glycidol is described. Orthogonal protection of this novel cyclic Ξ±-hydrazino acid allows for selective functionalisation at either NΞ³ or NΞ΄. This novel peptidomimetic building block was incorporated into the pseudotripeptides Gly-Ξ³aAze-Ala and Gly-Ξ΄aAze-Ala
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