On the Uncertainties of Stellar Mass Estimates via Colour Measurements

Mass-to-light versus colour relations (MLCRs), derived from stellar population synthesis models, are widely used to estimate galaxy stellar masses (M$_*$) yet a detailed investigation of their inherent biases and limitations is still lacking. We quantify several potential sources of uncertainty, using optical and near-infrared (NIR) photometry for a representative sample of nearby galaxies from the Virgo cluster. Our method for combining multi-band photometry with MLCRs yields robust stellar masses, while errors in M$_*$ decrease as more bands are simultaneously considered. The prior assumptions in one's stellar population modelling dominate the error budget, creating a colour-dependent bias of up to 0.6 dex if NIR fluxes are used (0.3 dex otherwise). This matches the systematic errors associated with the method of spectral energy distribution (SED) fitting, indicating that MLCRs do not suffer from much additional bias. Moreover, MLCRs and SED fitting yield similar degrees of random error ($\sim$0.1-0.14 dex) when applied to mock galaxies and, on average, equivalent masses for real galaxies with M$_* \sim$ 10$^{8-11}$ M$_{\odot}$. The use of integrated photometry introduces additional uncertainty in M$_*$ measurements, at the level of 0.05-0.07 dex. We argue that using MLCRs, instead of time-consuming SED fits, is justified in cases with complex model parameter spaces (involving, for instance, multi-parameter star formation histories) and/or for large datasets. Spatially-resolved methods for measuring M$_*$ should be applied for small sample sizes and/or when accuracies less than 0.1 dex are required. An Appendix provides our MLCR transformations for ten colour permutations of the $grizH$ filter set.Comment: Accepted to MNRAS. 43 pages, 12 figures, 3 table

The Changing Nature of Pharmaceutical R&D - Opportunities for Asia?

During the 1990''s, the pharmaceutical R&D process has witnessed tremendous technological changes. The emergence of new tools like ''combinatorial chemistry'', ''high throughput screening'' and the in-creasing use of computer-aided in silico experiments has led to significant improvements of research efficiency. This paper discusses the economic impact of this trend. It is argued that the resulting radical improvements in R&D productivity have lowered the minimum efficient scale in pharmeceutical research. As a consequence, the main bottleneck in pharmaceutical research has shifted from the mechanical act of synthesising and screening a sufficient number of active compounds to scientific excellence. Empirical finding indicate that the latter can more easily be achieved in smaller, highly focused firms. Accordingly, the most efficient way to currently conduct pharmaceutical R&D may be a new ''division of labour'' in research between small, highly specialised firms conducting research and large firms focusing on the development, testing, and marketing or new drugs. This reopens a ''window of opportunity'' for Asian pharmaceutical firms who had lost out in the previous race to ever increasing size.economics of technology ;

The Determinants of Pharmaceutical R&D Expenditures: Evidence from Japan

During the past 20 years, the world pharmaceutical industry has experienced a dramatic increase in R&D intensity. We apply and extend a model developed by Grabowski and Vernon (2000) with a pooled data sample of the 15 publicly listed Japanese drug firms for the period 1987 to 1998. As in the reference paper, we find expected returns to be an important determinant of R&D spending in the Japanese drug industry, albeit considerably smaller than in the U.S., which is particularly obvious in the case of returns from newly introduced drugs. However, our results are sensitive to econometric model specification, in particular to controlling for serial correlation and to a dynamic specification of the baseline model. Likewise, estimates on financial constraints are sensitive to model specification, indicating that Japanese drug firms face small or no financial constraints. Our results are consistent with the general literature on R&D investment behaviour, yet raise some methodological questions with regard to the original study.R&D, investment, panel data estimation, pharmaceuticals, Japan

HST-COS Spectroscopy of the Cooling Flow in Abell 1795 - Evidence for Inefficient Star Formation in Condensing Intracluster Gas

We present far-UV spectroscopy from the Cosmic Origins Spectrograph on the Hubble Space Telescope of a cool, star-forming filament in the core of Abell 1795. These data, which span 1025A - 1700A, allow for the simultaneous modeling of the young stellar populations and the intermediate-temperature (10^5.5 K) gas in this filament, which is far removed (~30 kpc) from the direct influence of the central AGN. Using a combination of UV absorption line indices and stellar population synthesis modeling, we find evidence for ongoing star formation, with the youngest stars having ages of 7.5 +/- 2.0 Myr and metallicities of 0.4 +/- 0.2 Zsun. The latter is consistent with the local metallicity of the intracluster medium. We detect the O VI (1038) line, measuring a flux of 4.0 +/- 0.9 x 10^-17 erg s^-1 cm^-2. The O VI (1032) line is redshifted such that it is coincident with a strong Galactic H2 absorption feature, and is not detected. The measured O VI (1038) flux corresponds to a cooling rate of 0.85 +/- 0.2 (stat) +/- 0.15 (sys) Msun/yr at ~10^5.5 K, assuming that the cooling proceeds isochorically, which is consistent with the classical X-ray luminosity-derived cooling rate in the same region. We measure a star formation rate of 0.11 +/- 0.02 Msun/yr from the UV continuum, suggesting that star formation is proceeding at 13 +/- 3% efficiency in this filament. We propose that this inefficient star formation represents a significant contribution to the larger-scale cooling flow problem.Comment: 6 pages, 4 figures. Accepted for publication in ApJ Letter

The Next Generation Virgo Cluster Survey (NGVS). XVIII. Measurement and Calibration of Surface Brightness Fluctuation Distances for Bright Galaxies in Virgo (and Beyond)

We describe a program to measure surface brightness fluctuation (SBF) distances to galaxies observed in the Next Generation Virgo Cluster Survey (NGVS), a photometric imaging survey covering $104~deg^2$ of the Virgo cluster in the ${u}^*,g,i,z$ bandpasses with the Canada-France Hawaii Telescope. We describe the selection of the sample galaxies, the procedures for measuring the apparent $i$-band SBF magnitude $\bar{i}$, and the calibration of the absolute $\bar{M}_i$ as a function of observed stellar population properties. The multi-band NGVS data set provides multiple options for calibrating the SBF distances, and we explore various calibrations involving individual color indices as well as combinations of two different colors. Within the color range of the present sample, the two-color calibrations do not significantly improve the scatter with respect to wide-baseline, single-color calibrations involving $u^{*}$. We adopt the ${u}^*{-}z$ calibration as reference for the present galaxy sample, with an observed scatter of 0.11 mag. For a few cases that lack good ${u}^*$ photometry, we use an alternative relation based on a combination of $g{-}i$ and $g{-}z$ colors, with only a slightly larger observed scatter of 0.12 mag. The agreement of our measurements with the best existing distance estimates provides confidence that our measurements are accurate. We present a preliminary catalog of distances for 89 galaxies brighter than $B_T\approx13.0$ mag within the survey footprint, including members of the background M and W Clouds at roughly twice the distance of the main body of the Virgo cluster. The extension of the present work to fainter and bluer galaxies is in progress.Comment: ApJ accepte

The infall of the Virgo elliptical galaxy M60 toward M87 and the gaseous structures produced by Kelvin-Helmholtz instabilities

We present Chandra observations of hot gas structures, characteristic of gas stripping during infall, in the Virgo cluster elliptical galaxy M60 (NGC4649) located 1 Mpc east of M87. 0.5−2 keV Chandra X-ray images show a sharp leading edge in the surface brightness 12.4±0.1 kpc north and west of the galaxy center in the direction of M87 characteristic of a merger cold front due to M60's motion through the Virgo ICM. We measured a temperature of 1.00±0.02 keV for abundance 0.5Z⊙ inside the edge and 1.37+0.35−0.19 keV for abundance 0.1Z⊙ in the Virgo ICM free stream region. We find that the observed jump in surface brightness yields a density ratio of 6.44+1.04−0.67 between gas inside the edge and in the cluster free stream region. If the edge is a cold front due solely to the infall of M60 in the direction of M87, we find a pressure ratio of 4.7+1.7−1.4 and Mach number 1.7±0.3. For 1.37 keV Virgo gas we find a total infall velocity for M60 of 1030±180 kms−1. We calculate the motion in the plane of the sky to be 1012+183−192 km−1 implying an inclination angle ξ=11±3 degrees. Surface brightness profiles show the presence of a faint diffuse gaseous tail. We identify filamentary, gaseous wing structures caused by the galaxy's motion through the ICM. The structure and dimensions of these wings are consistent with simulations of Kelvin-Helmholtz instabilities as expected if the gas stripping is close to inviscid

Stripped elliptical galaxies as probes of ICM physics : III. Deep Chandra observation of NGC 4552 - Measuring the viscosity of the intracluster medium

We present results from a deep (200 ks) Chandra observation of the early-type galaxy NGC 4552 (M89) which is falling into the Virgo cluster. Previous shallower X-ray observations of this galaxy showed a remnant gas core, a tail to the South of the galaxy, and twin `horns' attached to the northern edge of the gas core [machacek05a]. In our deeper data, we detect a diffuse, low surface brightness extension to the previously known tail, and measure the temperature structure within the tail. We combine the deep Chandra data with archival XMM-Newton observations to put a strong upper limit on the diffuse emission of the tail out to a large distance (10×the radius of the remnant core) from the galaxy center. In our two previous papers [roediger15a,roediger15b], we presented the results of hydrodynamical simulations of ram pressure stripping specifically for M89 falling into the Virgo cluster and investigated the effect of ICM viscosity. In this paper, we compare our deep data with our specifically tailored simulations and conclude that the observed morphology of the stripped tail in NGC 4552 is most similar to the inviscid models. We conclude that, to the extent the transport processes can be simply modeled as a hydrodynamic viscosity, the ICM viscosity is negligible. More generally, any micro-scale description of the transport processes in the high-β plasma of the cluster ICM must be consistent with the efficient mixing observed in the stripped tail on macroscopic scales

Stripped elliptical galaxies as probes of ICM physics: I. Tails, wakes, and flow patterns in and around stripped ellipticals

Elliptical cluster galaxies are progressively stripped of their atmospheres due to their motion through the intra-cluster medium (ICM). Deep X-ray observations reveal the fine-structure of the galaxy's remnant atmosphere and its gas tail and wake. This fine-structure depends on dynamic conditions (galaxy potential, initial gas contents, orbit through the host cluster), orbital stage (early infall, pre-/post-pericenter passage), and ICM plasma properties (thermal conductivity, viscosity, magnetic field structure). We aim to disentangle dynamic and plasma effects in order to use stripped ellipticals as probes of ICM plasma properties. This first paper of a series investigates the hydrodynamics of progressive gas stripping by means of inviscid hydrodynamical simulations. We distinguish a long-lasting initial relaxation phase and a quasi-steady stripping phase. During quasi-steady stripping, the ICM flow around the remnant atmosphere resembles the flow around solid bodies, including a `deadwater' region in the near wake. Gas is stripped from the remnant atmosphere predominantly at its sides via Kelvin-Helmholtz instabilities. The downstream atmosphere is largely shielded from the ICM wind and thus shaped into a tail. Observationally, both, this `remnant tail' and the stripped gas in the wake can appear as a `tail', but only in the wake can galactic gas mix with the ambient ICM. While the qualitative results are generic, the simulations presented here are tailored to the Virgo elliptical galaxy M89 (NGC 4552) for the most direct comparison to observations. Papers II and III of this series describe the effect of viscosity and compare to Chandra and XMM-Newton observations, respectively.Comment: ApJ, in press. 19 pages, 13 figures. Clarifications added, text restructured. Conclusions unchange