Carbon Isotopes Near Drip Lines in the Relativistic Mean-Field Theory

We have investigated the ground-state properties of carbon isotopes in the framework of the relativistic mean-field (RMF) theory. RMF calculations have been performed with the non-linear scalar self-coupling of the $\sigma$ meson using an axially symmetric deformed configuration. We have also introduced the vector self-coupling of the $\omega$ meson for the deformed mean-field calculations. The results show that the RMF predictions on radii and deformations are in good agreement with the available experimental data. It is shown that several carbon isotopes possess a highly deformed shape akin to a superdeformation. The single-particle structure of nuclei away from the stability line has been discussed with a view to understand the properties near the neutron drip line. Predictions of properties of carbon isotopes away from the stability line are made.Comment: Revtex, 29 pages, 11 postscript figures include

Shell Effects in Nuclei with Vector Self-Coupling of Omega Meson in Relativistic Hartree-Bogoliubov Theory

Shell effects in nuclei about the stability line are investigated within the framework of the Relativistic Hartree-Bogoliubov (RHB) theory with self-consistent finite-range pairing. Using 2-neutron separation energies of Ni and Sn isotopes, the role of $\sigma$- and $\omega$-meson couplings on the shell effects in nuclei is examined. It is observed that the existing successful nuclear forces (Lagrangian parameter sets) based upon the nonlinear scalar coupling of $\sigma$-meson exhibit shell effects which are stronger than suggested by the experimental data. We have introduced nonlinear vector self-coupling of $\omega$-meson in the RHB theory. It is shown that the inclusion of the vector self-coupling of $\omega$-meson in addition to the nonlinear scalar coupling of $\sigma$-meson provides a good agreement with the experimental data on shell effects in nuclei about the stability line. A comparison of the shell effects in the RHB theory is made with the Hartree-Fock Bogoliubov approach using the Skyrme force SkP. It is shown that the oft-discussed shell quenching with SkP is not consistent with the available experimental data.Comment: 34 pages latex, 18 ps figures, replaced with minor corrections in some figures, accepted for publication in Phys. Rev.

Functional Variant in Complement C3 Gene Promoter and Genetic Susceptibility to Temporal Lobe Epilepsy and Febrile Seizures

BACKGROUND: Human mesial temporal lobe epilepsies (MTLE) represent the most frequent form of partial epilepsies and are frequently preceded by febrile seizures (FS) in infancy and early childhood. Genetic associations of several complement genes including its central component C3 with disorders of the central nervous system, and the existence of C3 dysregulation in the epilepsies and in the MTLE particularly, make it the C3 gene a good candidate for human MTLE. METHODOLOGY/PRINCIPAL FINDINGS: A case-control association study of the C3 gene was performed in a first series of 122 patients with MTLE and 196 controls. Four haplotypes (HAP1 to 4) comprising GF100472, a newly discovered dinucleotide repeat polymorphism [(CA)8 to (CA)15] in the C3 promoter region showed significant association after Bonferroni correction, in the subgroup of MTLE patients having a personal history of FS (MTLE-FS+). Replication analysis in independent patients and controls confirmed that the rare HAP4 haplotype comprising the minimal length allele of GF100472 [(CA)8], protected against MTLE-FS+. A fifth haplotype (HAP5) with medium-size (CA)11 allele of GF100472 displayed four times higher frequency in controls than in the first cohort of MTLE-FS+ and showed a protective effect against FS through a high statistical significance in an independent population of 97 pure FS. Consistently, (CA)11 allele by its own protected against pure FS in a second group of 148 FS patients. Reporter gene assays showed that GF100472 significantly influenced C3 promoter activity (the higher the number of repeats, the lower the transcriptional activity). Taken together, the consistent genetic data and the functional analysis presented here indicate that a newly-identified and functional polymorphism in the promoter of the complement C3 gene might participate in the genetic susceptibility to human MTLE with a history of FS, and to pure FS. CONCLUSIONS/SIGNIFICANCE: The present study provides important data suggesting for the first time the involvement of the complement system in the genetic susceptibility to epileptic seizures and to epilepsy

Grouping and identification of Tuber species using RAPD markers

International audienc

Sicherheitsentscheidungen bei Arzneimitteln Eine politische Taetigkeit

Bibliothek Weltwirtschaft Kiel C100,327 / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEDEGerman

Typing Tuber ectomycorrhizae by polymerase chain amplification of the internal transcribed spacer of rDNA and the sequence characterized amplified region markers

International audienc

Caractérisation et identification de différentes espèces de Tuber par analyse de leur variabilité génétique

National audienc