4 research outputs found
Presence of Parabens and Bisphenols in Food Commonly Consumed in Spain
Given the widespread use of bisphenols and parabens in consumer products, the assessment of their intake is crucial and represents the first step towards the assessment of the potential risks that these compounds may pose to human health. In the present study, a total of 98 samples of food items commonly consumed by the Spanish population were collected from different national supermarkets and grocery stores for the determination of parabens and bisphenols. Our analysis demonstrated that 56 of the 98 food samples contained detectable levels of parabens with limits of quantification (LOQ) between 0.4 and 0.9 ng g-1. The total concentration of parabens (sum of four parabens: åparabens) ranged from below the LOQ to 281.7 ng g-1, with a mean value of 73.86 ng g-1. A total of 52% of the samples showed detectable concentrations of bisphenols. Bisphenol A (BPA) was the most frequently detected bisphenol in the food samples analysed, followed by bisphenol S (BPS) and bisphenol E (BPE). Bisphenol AF (BPAF), bisphenol B (BPB) and bisphenol P (BPP) were not found in any of the analysed samples. LOQ for these bisphenols were between 0.4 and 4.0 ng g-1
Levels of Bisphenol A and its analogs in nails, saliva, and urine of children: a case control study
Introduction: A growing number of studies link the increase in overweight/
obesity worldwide to exposure to certain environmental chemical pollutants that
display obesogenic activity (obesogens). Since exposure to obesogens during
the first stages of life has been shown to have a more intense and pronounced
effect at lower doses, it is imperative to study their possible effects in childhood.
The objective here was to study the association of Bisphenol A (BPA) and 11 BPA
analogs in children, using three biological matrices (nails, saliva and urine), and
overweight and obesity (n = 160).
Methods: In this case–control study, 59 overweight/obese children and 101
controls were included. The measuring of Bisphenols in the matrices was carried
out by ultra-high performance liquid chromatography coupled with triple
quadrupole tandem mass spectrometry (UHPLC-MS/MS). Logistic regression
was used to study the association between overweight/obesity and Bisphenol
exposure.
Results: The results suggested that BPF in nails is associated with overweight/
obesity in children (OR:4.87; p = 0.020). In saliva, however, the highest detected
concentrations of BPAF presented an inverse association (OR: 0.06; p = 0.010)
with overweight/obesity. No associations of statistical significance were detected
between exposure to BPA or its other analogs and overweight/obesity in any of
the biological matrices.FEDER-Consejería de Salud y Familias’ of the Junta de Andalucía PE-0250-201
Factors Associated with Exposure to Dietary Bisphenols in Adolescents
Obesogenic endocrine-disrupting chemicals, such as bisphenol A (BPA) and its analogue
bisphenol S (BPS), seem to play an important role in the development of obesity, although contradictory results have been reported. The aim of the present study was to conduct a gender analysis of
the factors associated with exposure to dietary bisphenols in 585 Spanish adolescents. Dietary BPA
and BPS exposure was assessed using a food frequency questionnaire. Foods and macronutrients
accounting for more than 95% of energy intake were selected for analysis. Stepwise regression
was used to estimate the foods that most contributed to dietary bisphenol exposure in the sample.
Gender-related factors associated with greater dietary bisphenol exposure were evaluated using
multivariate logistic regression models. Canned tuna was the main dietary source of BPA and BPS
in both adolescent boys and girls. Overweight/obese girls showed a higher risk of high dietary
exposure to BPA (odds ratio (OR): 3.38, 95% confidence interval (CI): 1.25–9.07) and total bisphenols
(OR: 2.81, 95% CI: 1.03–7.67) in comparison with girls with a BMI lower than 25 kg/m2
. Present
results indicate a positive association of dietary exposure to both total bisphenols and BPA with
being overweight/obese in adolescent girls.GP/EFSA/ENCO/380 2018/03/G04: OBEMIRISK: Knowledge platform for assessing the risk of bisphenol on gut microbiota and its role in
obesogenic phenotypes: looking for biomarkers’ frameworkPlan
Estatal de I + D + I 2013–2016FEDER-ISCIII PI17/01758FEDER-Consejería
de Salud y FamiliasJunta de Andalucía PE-0250–2019FEDER-Junta de Andalucía-Consejería de
Transformación Económica, Industria, Conocimiento y Universidades/ Proyecto P18-RT-4247Fundación Mapfre MAPFRE201
Bisphenol A Analogues in Food and Their Hormonal and Obesogenic Effects: A Review
Bisphenol A (BPA) is the most well-known compound from the bisphenol family. As BPA
has recently come under pressure, it is being replaced by compounds very similar in structure, but
data on the occurrence of these BPA analogues in food and human matrices are limited. The main
objective of this work was to investigate human exposure to BPA and analogues and the associated
health effects. We performed a literature review of the available research made in humans, in in vivo
and in vitro tests. The findings support the idea that exposure to BPA analogues may have an impact
on human health, especially in terms of obesity and other adverse health effects in children.This research was funded by Plan Estatal de I+D+I 2013-2016 Proyecto cofinanciado
FEDER-ISCIII PI17/01758 and by Fundación Mapfre MAPFRE2018