68 research outputs found

    Progressive loss in vitro of cellular immunity with ageing in strains of mice susceptible to autoimmune disease

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    The influence of ageing on the in vitro responses of mouse spleen cells to phytohaemagglutinin and to allogeneic cells was studied in NZB, (NZBĂ—A)F(1), A and CBA mice. These responses decline with ageing in those strains which are genetically susceptible to autoimmune disease (NZB, (NZBĂ—A)F(1) and A) but not in a non-susceptible strain (CBA). These studies support the view that cellular immunity declines with advancing age in autoimmune-susceptible mice, and suggests that the decline is due to a progressive loss of the thymus-dependent cell pool
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