Does Confidence Reporting from the Crowd Benefit Crowdsourcing Performance?

We explore the design of an effective crowdsourcing system for an $M$-ary classification task. Crowd workers complete simple binary microtasks whose results are aggregated to give the final classification decision. We consider the scenario where the workers have a reject option so that they are allowed to skip microtasks when they are unable to or choose not to respond to binary microtasks. Additionally, the workers report quantized confidence levels when they are able to submit definitive answers. We present an aggregation approach using a weighted majority voting rule, where each worker's response is assigned an optimized weight to maximize crowd's classification performance. We obtain a couterintuitive result that the classification performance does not benefit from workers reporting quantized confidence. Therefore, the crowdsourcing system designer should employ the reject option without requiring confidence reporting.Comment: 6 pages, 4 figures, SocialSens 2017. arXiv admin note: text overlap with arXiv:1602.0057

Application of isothermal titration calorimetry in evaluation of protein–nanoparticle interactions

Nanoparticles (NPs) offer a number of advantages over small organic molecules for controlling protein behaviour inside the cell. Protein binding to the surface of NPs depends on their surface characteristics, composition and method of preparation (Mandal et al. in J Hazard Mater 248–249:238–245, 2013). It is important to understand the binding affinities, stoichiometries and thermodynamical parameters of NP–protein interactions in order to see which interaction will have toxic and hazardous consequences and thus to prevent it. On the other side, because proteins are on the brink of stability, they may experience interactions with some types of NPs that are strong enough to cause denaturation or significantly change their conformations with concomitant loss of their biological function. Structural changes in the protein may cause exposure of new antigenic sites, “cryptic” peptide epitopes, potentially triggering an immune response which can promote autoimmune disease (Treuel et al. in ACS Nano 8(1):503–513, 2014). Mechanistic details of protein structural changes at NP surface have still remained elusive. Understanding the formation and persistence of the protein corona is critical issue; however, there are no many analytical methods which could provide detailed information about the NP–protein interaction characteristics and about protein structural changes caused by interactions with nanoparticles. The article reviews recent studies in NP–protein interactions research and application of isothermal titration calorimetry (ITC) in this research. The study of protein structural changes upon adsorption on nanoparticle surface and application of ITC in these studies is emphasized. The data illustrate that ITC is a versatile tool for evaluation of interactions between NPs and proteins. When coupled with other analytical methods, it is important analytical tool for monitoring conformational changes in proteins

In situ measurement of bovine serum albumin interaction with gold nanospheres

Here we present in situ observations of adsorption of bovine serum albumin (BSA) on citratestabilized gold nanospheres. We implemented scattering correlation spectroscopy as a tool to quantify changes in the nanoparticle Brownian motion resulting from BSA adsorption onto the nanoparticle surface. Protein binding was observed as an increase in the nanoparticle hydrodynamic radius. Our results indicate the formation of a protein monolayer at similar albumin concentrations as those found in human blood. Additionally, by monitoring the frequency and intensity of individual scattering events caused by single gold nanoparticles passing the observation volume, we found that BSA did not induce colloidal aggregation, a relevant result from the toxicological viewpoint. Moreover, to elucidate the thermodynamics of the gold nanoparticle-BSA association, we measured an adsorption isotherm which was best described by an anti-cooperative binding model. The number of binding sites based on this model was consistent with a BSA monolayer in its native state. In contrast, experiments using poly-ethylene glycol capped gold nanoparticles revealed no evidence for adsorption of BSA

German(ic) in language contact: Grammatical and sociolinguistic dynamics

It is well-known that contact between speakers of different languages or varieties leads to dynamics in many respects. From a grammatical perspective, especially contact between closely related languages/varieties fosters contact-induced innovations. The evaluation of such innovations reveals speakers’ attitudes and is in turn an important aspect of the sociolinguistic dynamics linked to language contact. In this volume, we assemble studies on such settings where typologically congruent languages are in contact, i.e. language contact within the Germanic branch of the Indo-European language family. Languages involved include Afrikaans, Danish, English, Frisian, (Low and High) German, and Yiddish. The main focus is on constellations where a variety of German is involved (which is why we use the term ‘German(ic)’ in this book). So far, studies on language contact with Germanic varieties have often been separated according to the different migration scenarios at hand, which resulted in somewhat different research traditions. For example, the so-called Sprachinselforschung (research on ‘language islands’) has mainly been concerned with settings caused by emigration from the continuous German-speaking area in Central Europe to locations in Central and Eastern Europe and overseas, thus resulting in some variety of German abroad. However, from a linguistic point of view it does not seem to be necessary to distinguish categorically between contact scenarios within and outside of Central Europe if one thoroughly considers the impact of sociolinguistic circumstances, including the ecology of the languages involved (such as, for instance, German being the majority language and the monolingual habitus prevailing in Germany, but completely different constellations elsewhere). Therefore, we focus on language contact as such in this book, not on specific migration scenarios. Accordingly, this volume includes chapters on language contact within and outside of (Central) Europe. In addition, the settings studied differ as regards the composition and the vitality of the languages involved. The individual chapters view language contact from a grammar-theoretical perspective, focus on lesser studied contact settings (e.g. German in Namibia), make use of new corpus linguistic resources, analyse data quantitatively, study language contact phenomena in computer-mediated communication, and/or focus on the interplay of language use and language attitudes or ideologies. These different approaches and the diversity of the scenarios allow us to study many different aspects of the dynamics induced by language contact. With this volume, we hope to exploit this potential in order to shed some new light on the interplay of language contact, variation and change, and the concomitant sociolinguistic dynamics. Particularly, we hope to contribute to a better understanding of closely related varieties in contact

German(ic) in language contact: Grammatical and sociolinguistic dynamics

It is well-known that contact between speakers of different languages or varieties leads to dynamics in many respects. From a grammatical perspective, especially contact between closely related languages/varieties fosters contact-induced innovations. The evaluation of such innovations reveals speakers’ attitudes and is in turn an important aspect of the sociolinguistic dynamics linked to language contact. In this volume, we assemble studies on such settings where typologically congruent languages are in contact, i.e. language contact within the Germanic branch of the Indo-European language family. Languages involved include Afrikaans, Danish, English, Frisian, (Low and High) German, and Yiddish. The main focus is on constellations where a variety of German is involved (which is why we use the term ‘German(ic)’ in this book). So far, studies on language contact with Germanic varieties have often been separated according to the different migration scenarios at hand, which resulted in somewhat different research traditions. For example, the so-called Sprachinselforschung (research on ‘language islands’) has mainly been concerned with settings caused by emigration from the continuous German-speaking area in Central Europe to locations in Central and Eastern Europe and overseas, thus resulting in some variety of German abroad. However, from a linguistic point of view it does not seem to be necessary to distinguish categorically between contact scenarios within and outside of Central Europe if one thoroughly considers the impact of sociolinguistic circumstances, including the ecology of the languages involved (such as, for instance, German being the majority language and the monolingual habitus prevailing in Germany, but completely different constellations elsewhere). Therefore, we focus on language contact as such in this book, not on specific migration scenarios. Accordingly, this volume includes chapters on language contact within and outside of (Central) Europe. In addition, the settings studied differ as regards the composition and the vitality of the languages involved. The individual chapters view language contact from a grammar-theoretical perspective, focus on lesser studied contact settings (e.g. German in Namibia), make use of new corpus linguistic resources, analyse data quantitatively, study language contact phenomena in computer-mediated communication, and/or focus on the interplay of language use and language attitudes or ideologies. These different approaches and the diversity of the scenarios allow us to study many different aspects of the dynamics induced by language contact. With this volume, we hope to exploit this potential in order to shed some new light on the interplay of language contact, variation and change, and the concomitant sociolinguistic dynamics. Particularly, we hope to contribute to a better understanding of closely related varieties in contact

German(ic) in language contact: Grammatical and sociolinguistic dynamics

It is well-known that contact between speakers of different languages or varieties leads to dynamics in many respects. From a grammatical perspective, especially contact between closely related languages/varieties fosters contact-induced innovations. The evaluation of such innovations reveals speakers’ attitudes and is in turn an important aspect of the sociolinguistic dynamics linked to language contact. In this volume, we assemble studies on such settings where typologically congruent languages are in contact, i.e. language contact within the Germanic branch of the Indo-European language family. Languages involved include Afrikaans, Danish, English, Frisian, (Low and High) German, and Yiddish. The main focus is on constellations where a variety of German is involved (which is why we use the term ‘German(ic)’ in this book). So far, studies on language contact with Germanic varieties have often been separated according to the different migration scenarios at hand, which resulted in somewhat different research traditions. For example, the so-called Sprachinselforschung (research on ‘language islands’) has mainly been concerned with settings caused by emigration from the continuous German-speaking area in Central Europe to locations in Central and Eastern Europe and overseas, thus resulting in some variety of German abroad. However, from a linguistic point of view it does not seem to be necessary to distinguish categorically between contact scenarios within and outside of Central Europe if one thoroughly considers the impact of sociolinguistic circumstances, including the ecology of the languages involved (such as, for instance, German being the majority language and the monolingual habitus prevailing in Germany, but completely different constellations elsewhere). Therefore, we focus on language contact as such in this book, not on specific migration scenarios. Accordingly, this volume includes chapters on language contact within and outside of (Central) Europe. In addition, the settings studied differ as regards the composition and the vitality of the languages involved. The individual chapters view language contact from a grammar-theoretical perspective, focus on lesser studied contact settings (e.g. German in Namibia), make use of new corpus linguistic resources, analyse data quantitatively, study language contact phenomena in computer-mediated communication, and/or focus on the interplay of language use and language attitudes or ideologies. These different approaches and the diversity of the scenarios allow us to study many different aspects of the dynamics induced by language contact. With this volume, we hope to exploit this potential in order to shed some new light on the interplay of language contact, variation and change, and the concomitant sociolinguistic dynamics. Particularly, we hope to contribute to a better understanding of closely related varieties in contact

German(ic) in language contact: Grammatical and sociolinguistic dynamics

It is well-known that contact between speakers of different languages or varieties leads to dynamics in many respects. From a grammatical perspective, especially contact between closely related languages/varieties fosters contact-induced innovations. The evaluation of such innovations reveals speakers’ attitudes and is in turn an important aspect of the sociolinguistic dynamics linked to language contact. In this volume, we assemble studies on such settings where typologically congruent languages are in contact, i.e. language contact within the Germanic branch of the Indo-European language family. Languages involved include Afrikaans, Danish, English, Frisian, (Low and High) German, and Yiddish. The main focus is on constellations where a variety of German is involved (which is why we use the term ‘German(ic)’ in this book). So far, studies on language contact with Germanic varieties have often been separated according to the different migration scenarios at hand, which resulted in somewhat different research traditions. For example, the so-called Sprachinselforschung (research on ‘language islands’) has mainly been concerned with settings caused by emigration from the continuous German-speaking area in Central Europe to locations in Central and Eastern Europe and overseas, thus resulting in some variety of German abroad. However, from a linguistic point of view it does not seem to be necessary to distinguish categorically between contact scenarios within and outside of Central Europe if one thoroughly considers the impact of sociolinguistic circumstances, including the ecology of the languages involved (such as, for instance, German being the majority language and the monolingual habitus prevailing in Germany, but completely different constellations elsewhere). Therefore, we focus on language contact as such in this book, not on specific migration scenarios. Accordingly, this volume includes chapters on language contact within and outside of (Central) Europe. In addition, the settings studied differ as regards the composition and the vitality of the languages involved. The individual chapters view language contact from a grammar-theoretical perspective, focus on lesser studied contact settings (e.g. German in Namibia), make use of new corpus linguistic resources, analyse data quantitatively, study language contact phenomena in computer-mediated communication, and/or focus on the interplay of language use and language attitudes or ideologies. These different approaches and the diversity of the scenarios allow us to study many different aspects of the dynamics induced by language contact. With this volume, we hope to exploit this potential in order to shed some new light on the interplay of language contact, variation and change, and the concomitant sociolinguistic dynamics. Particularly, we hope to contribute to a better understanding of closely related varieties in contact

German(ic) in language contact: Grammatical and sociolinguistic dynamics

It is well-known that contact between speakers of different languages or varieties leads to dynamics in many respects. From a grammatical perspective, especially contact between closely related languages/varieties fosters contact-induced innovations. The evaluation of such innovations reveals speakers’ attitudes and is in turn an important aspect of the sociolinguistic dynamics linked to language contact. In this volume, we assemble studies on such settings where typologically congruent languages are in contact, i.e. language contact within the Germanic branch of the Indo-European language family. Languages involved include Afrikaans, Danish, English, Frisian, (Low and High) German, and Yiddish. The main focus is on constellations where a variety of German is involved (which is why we use the term ‘German(ic)’ in this book). So far, studies on language contact with Germanic varieties have often been separated according to the different migration scenarios at hand, which resulted in somewhat different research traditions. For example, the so-called Sprachinselforschung (research on ‘language islands’) has mainly been concerned with settings caused by emigration from the continuous German-speaking area in Central Europe to locations in Central and Eastern Europe and overseas, thus resulting in some variety of German abroad. However, from a linguistic point of view it does not seem to be necessary to distinguish categorically between contact scenarios within and outside of Central Europe if one thoroughly considers the impact of sociolinguistic circumstances, including the ecology of the languages involved (such as, for instance, German being the majority language and the monolingual habitus prevailing in Germany, but completely different constellations elsewhere). Therefore, we focus on language contact as such in this book, not on specific migration scenarios. Accordingly, this volume includes chapters on language contact within and outside of (Central) Europe. In addition, the settings studied differ as regards the composition and the vitality of the languages involved. The individual chapters view language contact from a grammar-theoretical perspective, focus on lesser studied contact settings (e.g. German in Namibia), make use of new corpus linguistic resources, analyse data quantitatively, study language contact phenomena in computer-mediated communication, and/or focus on the interplay of language use and language attitudes or ideologies. These different approaches and the diversity of the scenarios allow us to study many different aspects of the dynamics induced by language contact. With this volume, we hope to exploit this potential in order to shed some new light on the interplay of language contact, variation and change, and the concomitant sociolinguistic dynamics. Particularly, we hope to contribute to a better understanding of closely related varieties in contact

German(ic) in language contact: Grammatical and sociolinguistic dynamics

It is well-known that contact between speakers of different languages or varieties leads to dynamics in many respects. From a grammatical perspective, especially contact between closely related languages/varieties fosters contact-induced innovations. The evaluation of such innovations reveals speakers’ attitudes and is in turn an important aspect of the sociolinguistic dynamics linked to language contact. In this volume, we assemble studies on such settings where typologically congruent languages are in contact, i.e. language contact within the Germanic branch of the Indo-European language family. Languages involved include Afrikaans, Danish, English, Frisian, (Low and High) German, and Yiddish. The main focus is on constellations where a variety of German is involved (which is why we use the term ‘German(ic)’ in this book). So far, studies on language contact with Germanic varieties have often been separated according to the different migration scenarios at hand, which resulted in somewhat different research traditions. For example, the so-called Sprachinselforschung (research on ‘language islands’) has mainly been concerned with settings caused by emigration from the continuous German-speaking area in Central Europe to locations in Central and Eastern Europe and overseas, thus resulting in some variety of German abroad. However, from a linguistic point of view it does not seem to be necessary to distinguish categorically between contact scenarios within and outside of Central Europe if one thoroughly considers the impact of sociolinguistic circumstances, including the ecology of the languages involved (such as, for instance, German being the majority language and the monolingual habitus prevailing in Germany, but completely different constellations elsewhere). Therefore, we focus on language contact as such in this book, not on specific migration scenarios. Accordingly, this volume includes chapters on language contact within and outside of (Central) Europe. In addition, the settings studied differ as regards the composition and the vitality of the languages involved. The individual chapters view language contact from a grammar-theoretical perspective, focus on lesser studied contact settings (e.g. German in Namibia), make use of new corpus linguistic resources, analyse data quantitatively, study language contact phenomena in computer-mediated communication, and/or focus on the interplay of language use and language attitudes or ideologies. These different approaches and the diversity of the scenarios allow us to study many different aspects of the dynamics induced by language contact. With this volume, we hope to exploit this potential in order to shed some new light on the interplay of language contact, variation and change, and the concomitant sociolinguistic dynamics. Particularly, we hope to contribute to a better understanding of closely related varieties in contact