1 research outputs found
Pd-Catalyzed Asymmetric β‑Hydride Elimination en Route to Chiral Allenes
We
wish to report our preliminary results on the discovery and
development of a catalytic, asymmetric β-hydride elimination
from vinyl PdÂ(II)-complexes derived from enol triflates to access
chiral allenes. To achieve this, we developed a class of chiral phosphite
ligands that demonstrate high enantioselectivity, allow access of
either allene enantiomer, and are readily synthesized. The methodology
is demonstrated on over 20 substrates, and application to the formal
asymmetric total synthesis of the natural product, (+)-epibatidine,
is also provided