Becaplermin gel in the treatment of pressure ulcers: a phase II randomized, double-blind, placebo-controlled study

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/72172/1/j.1524-475X.1999.00141.x.pd

Effect of cytokine growth factors on the prevention of acute wound failure

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/73237/1/j.1067-1927.2004.012109.x.pd

The Effect of Amnion-derived Cellular Cytokine Solution on the Epithelialization of Partial-thickness Donor Site Wounds in Normal and Streptozotocin-induced Diabetic Swine

Objective: The purpose of this study was to determine whether amnion-derived cellular cytokine solution (ACCS) could improve the quality of epithelialization and accelerate closure of dermatome-created partial-thickness wounds in normal and streptozotocin-induced diabetic pigs. Methods: Dermatome-created partial-thickness wounds were sealed with wound chambers in healthy and diabetic pigs and were injected with ACCS. Wound fluid was exchanged daily for total protein concentration, and biopsies were taken on days 6, 8, 10, and 12. Epithelialization, thickness of epidermis, number of epidermal cell layers, and rete ridges were evaluated. Results: The macroscopic appearance of the wounds and speed of healing was similar in all groups at each time point. All wounds were healed by day 6. The epidermis was thicker in the ACCS-treated diabetic wounds than in the controls (140.6 μm vs 82.7 μm on day 12 in diabetic pigs). There were more cell layers (13 vs 7.7) in ACCS-treated diabetic pigs on day 12. The number of rete ridges per 2.5 mm was greater on day 12 in the ACCS-treated diabetic wounds (13 vs 8). There was also a significant increase in the number of rete ridges in ACCS-treated nondiabetic pigs but no difference in epidermal thickness or number of cell layers. Conclusion: In diabetic pigs, we found a significantly thicker epidermis and more cell layers and rete ridges in the ACCS-treated wounds. Healthy pigs showed more rete ridges but no difference in thickness of epidermis or number of cell layers on day 12

Use of the wound healing trajectory as an outcome determinant for acute wound healing

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/72454/1/j.1524-475x.2000.00511.x.pd

On the Path Integral Loop Representation of (2+1) Lattice Non-Abelian Theory

A gauge invariant Hamiltonian representation for SU(2) in terms of a spin network basis is introduced. The vectors of the spin network basis are independent and the electric part of the Hamiltonian is diagonal in this representation. The corresponding path integral for SU(2) lattice gauge theory is expressed as a sum over colored surfaces, i.e. only involving the $j_p$ attached to the lattice plaquettes. This surfaces may be interpreted as the world sheets of the spin networks In 2+1 dimensions, this can be accomplished by working in a lattice dual to a tetrahedral lattice constructed on a face centered cubic Bravais lattice. On such a lattice, the integral of gauge variables over boundaries or singular lines -- which now always bound three coloured surfaces -- only contributes when four singular lines intersect at one vertex and can be explicitly computed producing a 6-j or Racah symbol. We performed a strong coupling expansion for the free energy. The convergence of the series expansions is quite different from the series expansions which were performed in ordinary cubic lattices. In the case of ordinary cubic lattices the strong coupling expansions up to the considered truncation number of plaquettes have the great majority of their coefficients positive, while in our case we have almost equal number of contributions with both signs. Finally, it is discused the connection in the naive coupling limit between this action and that of the B-F topological field theory and also with the pure gravity action.Comment: 16 pages, REVTEX, 8 Encapsulated Postscript figures using psfig, minor changes in text and reference