E-testing in Graduate Courses: Reflective Practice Case Studies

Do testing and exam conditions make a difference in final exam grades? Do testing “out of class” and “in class” produce different results over the same courses? Several graduate courses (N = 84) were tested under different and varying conditions. The majority of students were international, where English was a second language. In general, the “online” e-testers performed at a higher level than the ““in class”” testers with and without any time restrictions while test taking. Tentative implications might be that online exams (less controls) yield grades which are possibly higher, and may or may not be “grade inflated.” On the other hand, possibly less controls in exams yield more learning and higher retention of course content

Seamless Learning and Training, Extending the Classroom: Reflective Practice Case Studies

The purpose of these case analyses is to examine key characteristics and attributes that contribute to adult learning and training via several software videoconferencing-webinar products. The cases were from graduate classes and several businesses which provided the sample data. Sources of evidence for the cases were personal interviews, student “reactive” surveys, online observations (and views), oral histories, online discussions, and recorded video classroom sessions. Our findings suggest that over an 11 week course, students would like a blended learning approach with 3 to 4 sessions in class and 7 to 8 sessions using real-time videoconferencing software (with screen sharing). Sixty percent of the students stated they would enroll in such a course. Convenience, ease of use, and concentrated focus were noted as positive attributes of video conferencing. Business noted that lower costs and meeting customer needs were key factors in using online conferencing. The business community noted that for very specific topical content, webinars were most popular and effective to meet their training needs. Several participants mentioned that technical difficulties (background noise, audio quality) limited the real time, synchronous videoconferencing. Several participants mentioned that webinars are more cost effective than in class training while producing the same or very similar results as attending a seminar in class on the ground

BRCA2 Polymorphic Stop Codon K3326X and the Risk of Breast, Prostate, and Ovarian Cancers

Background: The K3326X variant in BRCA2 (BRCA2∗c.9976A>T p.Lys3326∗rs11571833) has been found to be associated with small increased risks of breast cancer. However, it is not clear to what extent linkage disequilibrium with fully pathogenic mutations might account for this association. There is scant information about the effect of K3326X in other hormonerelated cancers. Methods: Using weighted logistic regression, we analyzed data from the large iCOGS study including 76637 cancer case patients and 83796 control patients to estimate odds ratios (ORw) and 95% confidence intervals (CIs) for K3326X variant carriers in relation to breast, ovarian, and prostate cancer risks, with weights defined as probability of not having a pathogenic BRCA2 variant. Using Cox proportional hazards modeling, we also examined the associations of K3326X with breast and ovarian cancer risks among 7183 BRCA1 variant carriers. All statistical tests were two-sided. Results: The K3326X variant was associated with breast (ORw = 1.28, 95% CI = 1.17 to 1.40, P = 5.9×10-6) and invasive ovarian cancer (ORw = 1.26, 95% CI = 1.10 to 1.43, P = 3.8×10-3). These associations were stronger for serous ovarian cancer and for estrogen receptor-negative breast cancer (ORw = 1.46, 95% CI = 1.2 to 1.70, P = 3.4×10-5 and ORw = 1.50, 95% CI = 1.28 t

BRCA2 Polymorphic stop codon K3326X and the risk of breast, prostate, and ovarian cancers

Q1Q1Artículo Original1-10Background: The K3326X variant in BRCA2 (BRCA2*c.9976A>T; p.Lys3326*; rs11571833) has been found to be associated with small increased risks of breast cancer. However, it is not clear to what extent linkage disequilibrium with fully pathogenic mutations might account for this association. There is scant information about the effect of K3326X in other hormonerelated cancers. Methods: Using weighted logistic regression, we analyzed data from the large iCOGS study including 76 637 cancer case patients and 83 796 control patients to estimate odds ratios (ORw) and 95% confidence intervals (CIs) for K3326X variant carriers in relation to breast, ovarian, and prostate cancer risks, with weights defined as probability of not having a pathogenic BRCA2 variant. Using Cox proportional hazards modeling, we also examined the associations of K3326X with breast and ovarian cancer risks among 7183 BRCA1 variant carriers. All statistical tests were two-sided. Results: The K3326X variant was associated with breast (ORw = 1.28, 95% CI = 1.17 to 1.40, P = 5.9x10-6) and invasive ovarian cancer (ORw = 1.26, 95% CI = 1.10 to 1.43, P = 3.8x10-3). These associations were stronger for serous ovarian cancer and for estrogen receptor–negative breast cancer (ORw = 1.46, 95% CI = 1.2 to 1.70, P = 3.4x10-5 and ORw = 1.50, 95% CI = 1.28 to 1.76, P = 4.1x10-5, respectively). For BRCA1 mutation carriers, there was a statistically significant inverse association of the K3326X variant with risk of ovarian cancer (HR = 0.43, 95% CI = 0.22 to 0.84, P = .013) but no association with breast cancer. No association with prostate cancer was observed. Conclusions: Our study provides evidence that the K3326X variant is associated with risk of developing breast and ovarian cancers independent of other pathogenic variants in BRCA2. Further studies are needed to determine the biological mechanism of action responsible for these associations