Circumareolar Mastopexy with Multiple Glandular Plications for Symmetry of the Contra-Lateral Breast, in Patients Undergoing Breast Reconstruction with Prosthesis. Experience on 50 Cases

4 years experience on 50 cases using the Elliott’s technique for symmetrization of the contra-lateral breast in patients undergoing breast reconstruction with an anatomical prosthesis is presented in this paper

La actualización en Ciencias Veterinarias una necesidad para “una salud”

Una vez más el Colegio Médico Veterinario de la Provincia de Córdoba apostó al perfeccionamiento, actualización científica y a la camaradería, una prioridad de nuestra institución desde hace cuarenta años casi consecutivos, aprendiendo año a año, tendiendo a superar las expectativas, es por ello que este año los días 8, 9 y 10 de septiembre, se llevaron a cabo las 40º Jornadas de Actualización de Ciencias Veterinarias, en el tradicional Hotel Luz y Fuerza de la Localidad de Villa Giardino Córdoba. Comenzó el viernes con el acto inauguran, en donde contamos con la presencia de autoridades Provinciales y Municipales de Villa Giardino; autoridades del CMVPC, el Sr Presidente MV Marcelo Calle, la Sra. Secretaria MV Natalia Elstner y miembros del Consejo Directivo; presidentes e integrantes del otros Colegios Profesionales, como también del FECOVET; autoridades de las Universidades y Facultades de Veterinaria, como de nuestra Facultad de Ciencias Agropecuarias, el Sr. Mgter. MV Leonel Alisio, al que le agradezco su apoyo y por su intermedio a todo el personal a su cargo. En este encuentro quisimos prestigiar la excelencia y el esfuerzo de los mejores promedios de las Carreras de Veterinaria de la tres Universidades de la Provincia la UCC, UNVM y UNRC, con beca completa, que portaron con orgullo la enseña patria en el acto inaugural, fue un orgullo tenerlos presentes y esperamos que hayan sido un ejemplo a imitar, ya que el único camino para enaltecer nuestra profesión es el esfuerzo, el estudio y el crecimiento diario en el conocimiento, como también la empatía con nuestros pacientes y las personas responsables de los mismos

Solar photodegradation of irinotecan in water: optimization and robustness studies by experimental design

Irinotecan, a widely prescribed anticancer drug, is an emerging contaminant of concern that has been detected in various aquatic environments due to ineffective removal by traditional wastewater treatment systems. Solar photodegradation is a viable approach that can effectively eradicate the drug from aqueous systems. In this study, we used the design of experiment (DOE) approach to explore the robustness of irinotecan photodegradation under simulated solar irradiation. A full factorial design, including a star design, was applied to study the effects of three parameters: initial concentration of irinotecan (1.0-9.0 mg/L), pH (5.0-9.0), and irradiance (450-750 W/m(2)). A high-performance liquid chromatography coupled with a high-resolution mass spectrometry (HPLC-HRMS) system was used to determine irinotecan and identify transformation products. The photodegradation of irinotecan followed a pseudo-first order kinetics. In the best-fitted linear model determined by the stepwise model fitting approach, pH was found to have about 100-fold greater effect than either irinotecan concentration or solar irradiance. Under optimal conditions (irradiance of 750 W/m(2), 1.0 mg/L irinotecan concentration, and pH 9.0), more than 98% of irinotecan was degraded in 60 min. With respect to irradiance and irinotecan concentration, the degradation process was robust in the studied range, implying that it may be effectively applied in locations and/or seasons with solar irradiance as low as 450 W/m(2). However, pH needs to be strictly controlled and kept between 7.0 and 9.0 to maintain the degradation process robust. Considerations about the behavior of degradation products were also drawn

Technical feasibility and modeling of enzymatic pre-treatments of organic fraction of municipal solid waste to improve anaerobic digestion

The study explored the combined effects of enzymatic pre-treatment and anaerobic digestion (AD) on the organic fraction of municipal solid wastes (OFMSW) through experimental and multicriteria decision-making approaches. Five enzymes (UPP2, MPCS, USC4, USE2, and A. niger) and their dosages were studied. AD parameters included two inoculum origins (waste active sludge - WAS - and cow-agricultural sludge - CAS), the substrate: inoculum (SI) ratio, and inoculum incubation time (INOC). Desirability functions were used to optimize the multiple experimental responses simultaneously by converting each of them into values from 0 (unacceptable) to 1 (completely acceptable) and then combining these into a global desirability (D). D highlighted that higher enzyme dosages, INOC, and SI, improved AD performances, with optimal DOSE (at the highest level adopted for each enzyme) and INOC (5-10 d). AD tests with the five enzymes increased CH4 production by 10-13%v/v compared to untreated OFMSW. For UPP2 and MPCS, increasing DOSE boosted the biogas production, while increasing INOC enhanced the CH4 content. MPCS reached the highest efficiency (478. 43 NL CH4/kg (VS) with CAS, SI = 2:1, INOC = 10 d), followed by UPP2. Furthermore, higher INOC reduced A. niger doses, increasing CH4 production by 9%v/v compared to literature, with 5-10 d INOC (452.86 NL s/kg (VS) with WAS, SI = 2:1)

Proteins involved in biotic and abiotic stress responses as the most significant biomarkers in the ripening of Pinot Noir skins

We propose an integrated approach, obtained by the combination of multivariate statistics and proteomics, useful to isolate candidate biomarkers for the evaluation of grape ripening. We carried out a comparative 2-DE analysis of grape skins collected in three moments of ripening and analyzed the spot volume dataset through the application of principal component analysis followed by forward stepwiselinear discriminant analysis. This technique allowed to discriminate v\ue9raison, quite mature and mature samples, and to sort the matched spots according to their significance. We identified 36 spots showing high discriminating coefficients through liquid chromatography - electrospray ionization - tandem mass spectrometry (LC-ESI-MS/MS). Most of them were involved in biotic and abiotic stress responses indicating these enzymes as good candidate markers of berry ripening. These evidences hint at a likely developmental role of these proteins, in addition to their reported activity in stress events. Restricting the same statistical analysis to the samples belonging to the two last stages, it was indicated that this approach can clearly distinguish these close and similar phases of berry development. Taken all together, these results bear out that the employment of the combination of 2-DE and multivariate statistics is a reliable tool in the identification of new protein markers for describing the ripening phases and to assess the overall quality of the fruit