Flow cytometry analysis of MAbs VG-IgG2κ, VG-IgM, and X4 reactivity against the CEA-expressing CO115-5F12 human colon carcinoma cell line (A) and NCA-expressing human granulocytes (B)

<p><b>Copyright information:</b></p><p>Taken from "Fully human IgG and IgM antibodies directed against the carcinoembryonic antigen (CEA) Gold 4 epitope and designed for radioimmunotherapy (RIT) of colorectal cancers"</p><p>BMC Cancer 2004;4():75-75.</p><p>Published online 15 Oct 2004</p><p>PMCID:PMC526287.</p><p>Copyright © 2004 Garambois et al; licensee BioMed Central Ltd.</p> 12A11 and 16B10 are two human anti-CEA MAbs that cross-react with NCA. 192 is a murine anti-CEA MAb that cross-reacts with NCA. Binding of the different primary antibodies was detected using either anti-human κ chain, anti-human μ chain, or anti-mouse γ chain as indicated

Precipitation of I-CEA with MAbs VG-IgG2κ (■), VG-IgM (▲), and X4 (●) following incubation in a soluble phase assay

<p><b>Copyright information:</b></p><p>Taken from "Fully human IgG and IgM antibodies directed against the carcinoembryonic antigen (CEA) Gold 4 epitope and designed for radioimmunotherapy (RIT) of colorectal cancers"</p><p>BMC Cancer 2004;4():75-75.</p><p>Published online 15 Oct 2004</p><p>PMCID:PMC526287.</p><p>Copyright © 2004 Garambois et al; licensee BioMed Central Ltd.</p

Biodistribution study of I-VG-IgG2κ (■) as compared with I-X4 (○) in LS174T tumor bearing nude mice dissected 24 and 72 h after i

<p><b>Copyright information:</b></p><p>Taken from "Fully human IgG and IgM antibodies directed against the carcinoembryonic antigen (CEA) Gold 4 epitope and designed for radioimmunotherapy (RIT) of colorectal cancers"</p><p>BMC Cancer 2004;4():75-75.</p><p>Published online 15 Oct 2004</p><p>PMCID:PMC526287.</p><p>Copyright © 2004 Garambois et al; licensee BioMed Central Ltd.</p>v. co-injection. The tissues shown are (from left to right) tumor, liver, kidneys, lung, spleen, heart, muscle, bone, skin, stomach, low bowel, colon, carcass and blood. Results are expressed in terms of %ID/g ± SD