5 research outputs found
Contribution of Direct and Indirect Exposure to Human Serum Concentrations of Perfluorooctanoic Acid in an Occupationally Exposed Group of Ski Waxers
The contribution
of direct (i.e., uptake of perfluorooctanoic acid
(PFOA) itself) and indirect (i.e., uptake of 8:2 fluorotelomer alcohol
(FTOH) and metabolism to PFOA) exposure to PFOA serum concentrations
was investigated using a dynamic one-compartment pharmacokinetic (PK)
model. The PK model was applied to six occupationally exposed ski
waxers for whom direct and indirect exposures via inhalation were
characterized using multiple measurements with personal air sampling
devices. The model was able to predict the diverging individual temporal
trends of PFOA in serum with correlation coefficients of 0.82–0.94.
For the four technicians with high initial concentrations of PFOA
in serum (250–1050 ng/mL), the ongoing occupational exposure
(both direct and indirect) was of minor importance and net depuration
of PFOA was observed throughout the ski season. An estimated average
intrinsic elimination half-life of 2.4 years (1.8–3.1 years
accounting for variation between technicians and model uncertainty)
was derived for these technicians. The remaining two technicians,
who had much lower initial serum concentrations (10–17 ng/mL),
were strongly influenced by exposure during the ski season with indirect
exposure contributing to 45% of PFOA serum concentrations. On the
basis of these model simulations, an average metabolism yield of 0.003
(molar concentration basis; uncertainty range of 0.0006–0.01)
was derived for transformation of 8:2 FTOH to PFOA. An uncertainty
analysis was performed, and it was determined that the input parameters
quantifying the intake of PFOA were mainly responsible for the uncertainty
of the metabolism yield and the initial concentration of PFOA in serum
was mainly contributing to the uncertainty of estimated serum half-lives
Levels, Isomer Profiles, and Estimated Riverine Mass Discharges of Perfluoroalkyl Acids and Fluorinated Alternatives at the Mouths of Chinese Rivers
An
extensive sampling campaign was undertaken to study the levels,
isomer profiles and riverine mass discharges of perfluoroalkyl acids
(PFAAs) and fluorinated alternatives in 19 Chinese rivers. The levels
and homologue profiles of Σ<sub>10</sub>PFAAs varied considerably
among the 19 rivers (mean 106; median 16.3, range 8.9–1240
ng/L), indicating the influence of specific point sources. Highly
branched isomer profiles of perfluorooctanoic acid (18–25%
br-PFOA) in rivers with elevated concentrations (96–352 ng/L)
indicate that releases during production of PFOA by electrochemical
fluorination and/or its use in fluoropolymer manufacture were the
dominant sources to these rivers. The fluorinated alternatives 6:2
fluorotelomer sulfonate (detection frequency 21%, < 0.1–3.1
ng/L) and chlorinated polyfluoroalkyl ether sulfonate F-53B (51%,
< 0.56–78.5 ng/L) were also found in some rivers. The total
Chinese riverine mass discharges of PFOA (mean 80.9; range 16.8–168
t/y) (including monitoring data from this and other studies) were
in good agreement with theoretical PFOA emission estimates (17.3–203
t/y) whereas riverine mass discharges of PFOS (mean 3.6; range 1.9–5.6
t/y) could only account for a minor fraction of theoretically estimated
PFOS releases (70 t/y). This study provides empirical evidence that
emissions from Chinese point sources likely dominate the global emissions
of several legacy PFASs (notably PFOA) and fluorinated alternatives
(e.g., F-53B)
Geographical Differences in Dietary Exposure to Perfluoroalkyl Acids between Manufacturing and Application Regions in China
Emissions
of perfluoroalkyl acids (PFAAs) have increased in China
over the past decade, but human exposure pathways are poorly understood.
Here we analyzed 15 PFAAs in commonly consumed food items and calculated
body weight normalized dietary intake rates (estimated dietary intake,
EDIs) in an area with ongoing PFAA production (Hubei province; <i>n</i> = 121) and an urbanized coastal area (Zhejiang province; <i>n</i> = 106). Geographical differences in concentrations were
primarily observed for perfluorooctanesulfonic acid (PFOS) and perfluorohexanesulfonic
acid (PFHxS) in animal food items and short-chain PFAAs in vegetable
food items. The average EDI of ∑PFAAs for adults in Hubei (998
ng kg<sup>–1</sup> day<sup>–1</sup>) was more than 2
orders of magnitude higher than that in Zhejiang (9.03 ng kg<sup>–1</sup> day<sup>–1</sup>). In Hubei province, the average EDI of
PFOS for adults (87 ng kg<sup>–1</sup> day<sup>–1</sup>) was close to or exceeded advisory guidelines used in other countries
indicating health risks for the population from long-term exposure.
Yet, PFOS could only account for about 10% of the EDI of ∑PFAAs
in the Hubei province, which was dominated by short-chain PFAAs through
consumption of vegetables. The large contribution of short-chain PFAAs
to the total EDIs in manufacturing areas emphasize the need for improved
exposure and hazard assessment tools of these substances
Human Exposure and Elimination Kinetics of Chlorinated Polyfluoroalkyl Ether Sulfonic Acids (Cl-PFESAs)
The
incomplete mass-balance of organic fluorine in human serum
indicates the existence of unknown per- and polyfluoroalkyl substances
(PFASs) with persistent and bioaccumulative properties. Here we characterized
human exposure and elimination kinetics of chlorinated polyfluoroalkyl
ether sulfonic acids (Cl-PFESAs) in metal plating workers (<i>n</i> = 19), high fish consumers (<i>n</i> = 45),
and background controls (<i>n</i> = 8). Cl-PFESAs were detected
in >98% of the sampled individuals with serum concentrations ranging
<0.019–5040 ng/mL. Statistically higher median serum levels
were observed in high fish consumers (93.7 ng/mL) and metal plating
workers (51.5 ng/mL) compared to the background control group (4.78
ng/mL) (Kruskal–Wallis rank sum test, <i>p</i> <
0.01). Cl-PFESAs could account for 0.269 to 93.3% of ∑PFASs
in human serum indicating that this compound class may explain a substantial
fraction of previously unidentified organic fluorine in the Chinese
population. Estimated half-lives for renal clearance (median 280 years;
range 7.1–4230 years) and total elimination (median 15.3 years;
range 10.1–56.4 years) for the eight carbon Cl-PFESA suggest
that this is the most biopersistent PFAS in humans reported to date.
The apparent ubiquitous distribution and slow elimination kinetics
in humans underscore the need for more research and regulatory actions
on Cl-PFESAs and PFAS alternatives with similar chemical structures
Tissue Distribution and Whole Body Burden of the Chlorinated Polyfluoroalkyl Ether Sulfonic Acid F‑53B in Crucian Carp (<i>Carassius carassius</i>): Evidence for a Highly Bioaccumulative Contaminant of Emerging Concern
Following
the global actions to phase out perfluoroctanesulfonic
acid (PFOS) a large number of alternative per- and polyfluoroalkyl
substances, with poorly defined hazard properties, are being used
in increasing quantities. Here, we report on the first detection of
the chlorinated polyfluoroalkyl ether sulfonic acid F-53B in biological
samples and determine the tissue distribution and whole body bioaccumulation
factors (BAF<sub>whole body</sub>) in crucian carp (<i>Carassius
carassius</i>). Analysis of fish samples from Xiaoqing River
(XR) and Tangxun Lake (TL) demonstrated a similar level of F-53B contamination
with median concentrations in blood of 41.9 and 20.9 ng/g, respectively.
Tissue/blood ratios showed that distribution of F-53B primarily occurs
to the kidney (TL: 0.48, XR: 0.54), gonad (TL: 0.36, XR: 0.54), liver
(TL: 0.38, XR: 0.53), and heart (TL: 0.47, XR: 0.47). Median Log BAF<sub>whole body</sub> values for F-53B (XR: 4.124, TL: 4.322) exceeded
regulatory bioaccumulation criterion and were significantly higher
than those of PFOS in the same data sets (XR: 3.430, TL: 3.279). On
the basis of its apparent omnipresence and strong bioaccumulation
propensity, it is hypothesized that F-53B could explain a significant
fraction of previously unidentified organofluorine in biological samples
from China, and regulatory actions for this compound are encouraged