Food Availability as a Determinant of Weight Gain Among Renal Transplant Recipients

Renal transplantation is the treatment of choice for End Stage Renal Disease (ESRD), but one of the risks associated with this treatment is excessive weight gain. Several potential causes of this increased risk have been evaluated, but environmental factors have not yet been explored. This study used Geographic Information Systems (GIS) to evaluate the effect of number and ratio (number of one compared to all) of food sources (fast food restaurants, convenience stores, and grocery stores) within a one, two, and three mile buffer around transplant recipients\u27 residences (n = 484) on BMI change during the first year post-transplant. Multiple linear regression found that the only significant effect was seen in fast food ratio within a three-mile buffer of residence (p = .024). Future research is needed with larger sample sizes to explore the potential effects of food environment on post-renal transpalnt weight gain more accurately

Securing technology-critical metals for Britain

In the next 5-10 years the UK is going to see dramatic changes to many of its large industrial sectors, such as automotive, aerospace, and energy generation, as we move from a fossil-fuel-driven society to an electrically driven one. Many of these industries will be dependent on technology-critical metals (TCMs), for example, cobalt and lithium for the batteries in electric vehicles and rare-earths used in the magnets for electric motors and wind turbines. Many regions of the world, including the EU, have been developing strategies to access these technology-critical metals for their key industries, while the UK has lagged behind. The challenges already faced around access to key technology metals are potentially complicated for the UK by the nation’s exit from the EU, and the uncertainty that this has created with regard to trading relationships around the globe. It is in this challenging context that the UK must now fashion its own independent policy for access to technology critical metals

PREVENTIVE CARE UTILIZATION AND ITS IMPACT ON POTENTIALLY PREVENTABLE HOSPITALIZATIONS: IMPLICATIONS OF MEDICAID COST-SHARING, MEDICAID EXPANSION, AND THE AFFORDABLE CARE ACT FOR VULNERABLE POPULATIONS

About half of Americans have at least one chronic disease, and chronic diseases account for nearly 90% of healthcare expenditures in the US. Primary care can reduce potentially preventable hospitalizations and overall costs of chronic diseases. However, only about 3% of US healthcare spending is on prevention. Racial/ethnic disparities and income disparities have been well documented in the use of primary care. The ACA expanded insurance coverage for millions of Americans and included a mandate that all insurance plans must cover recommended preventive services at no cost to the patient. Literature shows the ACA resulted in an increase in access to care, but results on utilization rates of primary care post-ACA are mixed. Using nationally representative data sets from 2009-2015, I examined the utilization rates of preventive services among vulnerable populations after the full implementation of the ACA, and how Medicaid state policy and expansion under the ACA affected the utilization of preventive services among vulnerable populations. Next, using the Maryland Medical Care Database from 2012-2014, I examined how continuity of primary care affects the odds of having any hospitalization as well as potentially preventable hospitalizations. I found that the ACA was associated with an increase in preventive services recommended yearly, and the ACA was not associated with disparities in preventive service utilization among vulnerable populations. Additionally, I found that state Medicaid policies on preventive services were associated with increased utilization of flu shot, but Medicaid expansion was not associated with increased utilization of preventive services or many changes in disparities in preventive service utilization among vulnerable populations. Finally, I found that primary care, especially ongoing primary care, was strongly associated with a decrease in the odds of having any hospitalization and potentially preventable hospitalizations. Results suggest that increased access alone will not increase utilization rates and reduce health disparities, but rather, a focus on education of what coverage options are available through the ACA, the importance of ongoing primary care, and how to navigate the healthcare system once insured could increase utilization of preventive care, especially in vulnerable populations

Exploring contextual factors and patient activation: evidence from a nationally representative sample of patients with depression

Patient activation has been considered as a "blockbuster drug of the century." Patients with mental disorders are less activated compared to patients with other chronic diseases. Low activation due to mental disorders can affect the efficiency of treatment of other comorbidities. Contextual factors are significantly associated with mental health care access and utilization. However, evidence of their association with patient activation is still lacking. Using data from the Health Tracking Household Survey 2007 and Area Health Resource File 2008, we examine the association between contextual factors and self-reported activation levels among patients with depression. We investigate two types of contextual factors--(a) site of usual source of care and (b) community characteristics, measured by mental health care resources availability, population demographics, and socioeconomic characteristics at the county level. Results show significant variation in activation levels by contextual factors. The availability of community mental health centers, lower proportion of foreign-born individuals, and higher income in the local community are associated with higher patient activation. Our results also show that depressed patients having a usual source of care at a physician's office have significantly higher patient activation levels than those with a usual source of care in the emergency department or hospital outpatient clinics. Results suggest that primary care setting is critical to having a sustained relationship between patients and physicians in order to enhance patient engagement in mental health care. Interventions in communities with low income and high immigrant populations are necessary

Variation of preventive service utilization by state Medicaid coverage, cost-sharing, and Medicaid expansion status

Preventive services can help reduce costs associated with chronic conditions. Medicaid beneficiaries have high rates of chronic conditions, but state Medicaid coverage and cost-sharing of preventive services varies widely. States that chose to expand Medicaid under the ACA were incentivized to cover recommended preventive services at no cost-sharing. This study evaluates whether state Medicaid policy and Medicaid expansion were associated with overall utilization, and disparities in utilization of preventive services among vulnerable populations. We used Medicaid policy data from Kaiser Family Foundation and MEPS data (2009–2014, n = 15,610), collected and analyzed in 2017. We used multivariable logistic regression, difference-in-differences, and difference-in-difference-in-differences models to examine the association between state Medicaid preventive service policy and Medicaid expansion on overall utilization, and disparities in utilization among race/ethnicity and income groups for blood pressure check, cholesterol screening, and flu shot. Medicaid coverage of flu shot was significantly associated with utilization (p < 0.001). Medicaid expansion significantly increased flu shot utilization among near-poor individuals (p < 0.01), Asians, and Latinos and blood pressure screening among African Americans (p < 0.05). For flu shot, the ACA is reaching its target audience: those in the coverage gap between Medicaid and private insurance. Increasing access to preventive services may not be enough to increase utilization, especially for vulnerable populations and/or the previously uninsured. Focusing on provider adherence to preventive service guidelines and education around who is eligible for what service and when could help increase utilization of preventive services in the future. •Medicaid coverage of flu shot was associated with flu shot utilization.•Medicaid expansion increased flu shot utilization among the near-poor, Asians, and Latinos.•Medicaid expansion increased blood pressure screening among African Americans

Food availability as a determinant of weight gain among renal transplant recipients

Excessive weight gain is common after renal transplantation, but it is unknown whether environmental factors, such as food availability, contribute to this important clinical problem. We evaluated the effects of food availability (fast food restaurants, convenience stores, and grocery stores within 1, 2, and 3 mile buffers of transplant recipients\u27 residences) on body mass index (BMI) change during the first year post-transplant. Participants (n=299) resided in Memphis, Tennessee. BMI increased by 1.42 units (p\u3c.001) corresponding to an average weight gain of 9.25lbs (5.43%) during the first year post-transplant. The number of grocery stores within 1 mile of recipient\u27s residence was associated with an increase in BMI (p\u3c.05), but fast food restaurants and convenience stores were not significantly associated with BMI change. © 2014 Wiley Periodicals, Inc

1935. COVID-19 mRNA Vaccination Reduces the Occurrence of Post-COVID Conditions in U.S. Children Aged 5-17 Years Following Omicron SARS-CoV-2 Infection, July 2021-September 2022

Abstract Background An estimated 1-3% of children with SARS-CoV-2 infection will develop Post-COVID Conditions (PCC). This study evaluates mRNA COVID-19 vaccine impact on likelihood of PCC in children. Methods A multi-site cohort of children enrolled 7/21/2021-9/1/2022 underwent weekly SARS-CoV-2 screening tests and were surveyed via self- or parental report 12/1/2022-5/31/2023 regarding PCC (defined as ≥1 new or on-going symptoms lasting ≥ 1 month after infection). Multivariable logistic regression was performed to estimate the occurrence of PCC by vaccination status among children aged 5–17 years whose first PCR-confirmed SARS-CoV-2 infection occurred in-study with Omicron variant, who completed the survey >60 days from infection, and who were vaccine age-eligible at time of infection per ACIP recommendations. Vaccination status was categorized as vaccinated (at least primary series completed >14 days before infection) and unvaccinated (no vaccine doses before infection). Vaccination status was verified through vaccine registry and/or medical records. Results Of 622 participants surveyed, 5% (n=28) had PCC (Table 1) and 67% (n=474) were vaccinated (Table 2). Surveys were completed a median (IQR) of 203.7 days (119.0–293.0) after infection. Children with non-Hispanic Black race/ethnicity and good/fair/poor self-rated baseline health were more likely to report PCC. Children aged 12-18 years, Non-Hispanic Asian and White children, those reporting symptomatic SARS-CoV-2 infection, and those with excellent/very good self-rated baseline health were more likely to report vaccination When comparing children with and without PCC symptoms, COVID-19 mRNA vaccination was associated with a decreased likelihood of >1 PCC symptom (aOR 0.66, 95% CI 0.43-0.99), >2 PCC symptoms (aOR 0.52, 95% 0.32-0.83), and respiratory PCC symptoms (aOR 0.53, 95% CI 0.33-0.87) (Table 3). Figure 1.Relative Risk of Post-COVID Conditions among Patients who Received Paxlovid, Ages ≥50 (N=564,303)Figure 2.Relative Risk of Post-COVID Conditions among Patients who Received Paxlovid, Ages 18-49 (N=292,818)Figure 3.Relative Risk of Post-COVID Conditions among Patients who Received Paxlovid, Ages 12-17 (N=17,178) Conclusion In this study, mRNA COVID-19 vaccination appeared to be protective against PCC in children following Omicron SARS-CoV-2 infection. The adjusted ORs correspond to an estimated 34%, 48%, and 47% reduced likelihood of >1, >2, and respiratory PCC symptoms among vaccinated children, respectively. These findings support COVID-19 vaccination for children and may encourage increased pediatric vaccine uptake. Disclosures Lisa Gwynn, MBA, MSPH, Merck: Honorari

Hybrid immunity and SARS-CoV-2 antibodies: results of the HEROES-RECOVER prospective cohort study

There are limited data on whether hybrid immunity differs by count and order of immunity-conferring events (SARS-CoV-2 infection or COVID-19 vaccination). From a cohort of health care personnel, first responders, and other frontline workers in six US states, we examined heterogeneity of the effect of hybrid immunity on SARS-CoV-2 antibody levels. Exposures included event-count (sum of infections and vaccine doses) and event-order, categorized into seven permutations of vaccination and/or infection. Outcome was level of serum binding antibodies against receptor binding domain (RBD) of the ancestral SARS-CoV-2 spike protein (total RBD-binding Ig), measured by enzyme-linked immunosorbent assay. Mean antibody levels were examined up to 365 days after each of the 1st-7th events. Analysis included 5,793 participants measured from August 7, 2020 to April 15, 2023. Hybrid immunity from infection before one or two vaccine doses elicited modestly superior antibody responses after the 2nd and 3rd events (compared to infections or vaccine-doses alone). This superiority was not evident after the 4th and 5th events (additional doses). Among adults infected before vaccination, adjusted geometric mean ratios (95% CI) of anti-RBD early response (versus vaccinated-only) were 1.23 (1.14-1.33), 1.09 (1.03-1.14), 0.87 (0.81-0.94), and 0.99 (0.85-1.15) after the 2nd-5th events, respectively. Post-vaccination infections elicited superior responses: adjusted geometric mean ratios (95% CI) of anti-RBD early response (versus vaccinated-only) were: 0.93 (0.75-1.17), 1.11 (1.06-1.16), 1.17 (1.11-1.24), and 1.20 (1.07-1.34) after the 2nd-5th events, respectively. Findings reflecting heterogeneity in antibody levels by permutations of infection and vaccination history could inform COVID-19 vaccination policy